Francisco Martinez-Pena (@Fran_MPena) profile picture

Francisco Martinez-Pena

@Fran_MPena

Staff Scientist @scrippsresearch Medicinal Chemistry | Chemical Biology |

 San Diego
Joined August 2022
  • Tweets34
  • Following157
  • Followers72
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Photo by Francisco Martinez-Pena (@Fran_MPena)Photo by Francisco Martinez-Pena (@Fran_MPena)
Francisco Martinez-Pena retweeted
Relation (@RelationRx) profile picture
Relation
@RelationRx4 Oct 2023
We are excited to share our latest paper @CellPressNews on RECOVER which was co-led by our CIO Jake Taylor-King @wildtypehuman and Yoshua Bengio @Mila_Quebec   #cause2cure #patientiswaiting lnkd.in/eQXacmWS
Image from Relation (@RelationRx)
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Francisco Martinez-Pena retweeted
Total Synthesis (@TotalSynthesis) profile picture
Total Synthesis@TotalSynthesis20 Sep 2023
#Synthesis of portimines reveals the basis of their anti-cancer activity by Junchen Tang, @WChembio, Tzu-Yuan Chiu, @Fran_MPena, @LuoZengwei, Christine T. Chong, Qijia Wei, Nathalia Gazaniga, Thomas J. West, @YiyangSee, Luke L. Lairson, @_chrisgparker_, and Phil S. Baran @BaranLabReads in @Nature nature.com/articles/s41586-0…
Image from Total Synthesis (@TotalSynthesis)
Image from Total Synthesis (@TotalSynthesis)
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Francisco Martinez-Pena retweeted
Baran Lab (@BaranLabReads) profile picture
Baran Lab
@BaranLabReads20 Sep 2023
The final version of this study was published today in @Nature : nature.com/articles/s41586-0…
Baran Lab (@BaranLabReads) profile pictureBaran Lab
@BaranLabReads19 Jan 2023
Today we report in @ChemRxiv a scalable solution to the total synthesis (and structural reassignment) of the Portimines (bit.ly/3iJ61DT). In collaboration with @_chrisgparker_ and Luke Lairson the remarkable biological activity of this natural product family was revealed
Image from Baran Lab (@BaranLabReads)
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Francisco Martinez-Pena retweeted
Chris Parker (@_chrisgparker_) profile picture
Chris Parker@_chrisgparker_20 Sep 2023
Excited for this @scripps Chem collaborative work out in @Nature w/@BaranLabReads & Lairson Lab. Has a bit of something for everyone…herculean total synthesis, structural reassignment, chemoproteomics, new druggable target, in-depth functional characterization & more
Baran Lab (@BaranLabReads) profile pictureBaran Lab
@BaranLabReads20 Sep 2023
The final version of this study was published today in @Nature : nature.com/articles/s41586-0…
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I am delighted to share our work demonstrating the active role of hydroxyproline and collagen metabolism in modulating PD-L1 expression &implications for cancer immunotherapy sciencedirect.com/science/ar…
Image from Amelia Palermo Briosi, PhD (@Amelia_Palermo)
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I’m very glad to share our work on @InorgChem: “Reversible Chromism of Tethered Ruthenium(II) Complexes in the Solid State”. A bunch of thanks to @infante_tadeo, @pizarroam, and @josescostalab from @IMDEA_Nano. Thanks @Scixel for the cover. pubs.acs.org/doi/10.1021/acs…
Image from Francisco Martinez-Pena (@Fran_MPena)
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Francisco Martinez-Pena retweeted
Tommy West (@TommyWest54) profile picture
Tommy West@TommyWest545 Apr 2023
Very excited to share our paper in @J_A_C_S describing a prodrug that is selectively toxic to glioblastoma tumor cells. Huge thank you to Luke Lairson, @Fran_MPena, and our amazing collaborators @mischellab! @scrippsresearch pubs.acs.org/doi/10.1021/jac…
A Cell Type Selective YM155 Prodrug Targets Receptor-Interacting Protein Kinase 2 to Induce Brain...

A Cell Type Selective YM155 Prodrug Targets Receptor-Interacting Protein Kinase 2 to Induce Brain...

Abstract. Glioblastoma (GBM) is the most prevalent and aggressive primary central nervous system (CNS) malignancy. YM155 is a highly potent broad-spectrum

pubs.acs.org
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Fascinating talks by @_chrisgparker_ and Haoxin Li, from @scrippsresearch at #SLAS2023 today. They talked about difficult targets and expanding the ligandability of the proteome. The session was also hosted by @katenokv. Totally extraordinary and inspiring science!
Image from Francisco Martinez-Pena (@Fran_MPena)
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Francisco Martinez-Pena retweeted
Baran Lab (@BaranLabReads) profile picture
Baran Lab
@BaranLabReads19 Jan 2023
Today we report in @ChemRxiv a scalable solution to the total synthesis (and structural reassignment) of the Portimines (bit.ly/3iJ61DT). In collaboration with @_chrisgparker_ and Luke Lairson the remarkable biological activity of this natural product family was revealed
Image from Baran Lab (@BaranLabReads)
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Francisco Martinez-Pena retweeted
Total Synthesis (@TotalSynthesis) profile picture
Total Synthesis@TotalSynthesis22 Jan 2023
A Scalable #TotalSynthesis of Portimine A & B by Junchen Tang, @WChembio, Tzu-Yuan Chiu, @LuoZengwei, Christine Chong, Qijia Wei, @Fran_MPena, Nathalia Gazaniga, @YiyangSee, Luke Lairson, @_chrisgparker_, @BaranLabReads at @scrippsresearch in @ChemRxiv chemrxiv.org/engage/chemrxiv…
Image from Total Synthesis (@TotalSynthesis)
Image from Total Synthesis (@TotalSynthesis)
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Francisco Martinez-Pena retweeted
Ardem Patapoutian (@ardemp) profile picture
Ardem Patapoutian@ardemp5 Oct 2022
Huge congrats to @CarolynBertozzi, Meldal, and @scrippsresearch colleague Sharpless! A rare 2nd @NobelPrize for Barry and this makes it 2nd @NobelPrize for @scrippsresearch in last 2 years!
The Nobel Prize (@NobelPrize) profile pictureThe Nobel Prize
@NobelPrize5 Oct 2022
BREAKING NEWS: The Royal Swedish Academy of Sciences has decided to award the 2022 #NobelPrize in Chemistry to Carolyn R. Bertozzi, Morten Meldal and K. Barry Sharpless “for the development of click chemistry and bioorthogonal chemistry.”
Image from The Nobel Prize (@NobelPrize)
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Francisco Martinez-Pena retweeted
Scripps Research (@scrippsresearch) profile picture
Scripps Research
@scrippsresearch5 Oct 2022
Professor K. Barry Sharpless is only the fifth individual to have ever been awarded two lifetime Nobel Prizes. 2001 and 2022.
The Nobel Prize (@NobelPrize) profile pictureThe Nobel Prize
@NobelPrize5 Oct 2022
Barry Sharpless has just become the fifth individual to be awarded two Nobel Prizes. He follows in the footsteps of double #NobelPrize laureates John Bardeen, Marie Skłodowska Curie, Linus Pauling and Frederick Sanger. Sharpless was awarded the chemistry prize in 2001 and 2022
Image from The Nobel Prize (@NobelPrize)
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Francisco Martinez-Pena retweeted
Shenvi Lab (@Shenvi_Lab) profile picture
Shenvi Lab@Shenvi_Lab5 Oct 2022
As I tell my kids, it takes alkynes to make a world. What a great time to be @scrippsresearch
The Nobel Prize (@NobelPrize) profile pictureThe Nobel Prize
@NobelPrize5 Oct 2022
BREAKING NEWS: The Royal Swedish Academy of Sciences has decided to award the 2022 #NobelPrize in Chemistry to Carolyn R. Bertozzi, Morten Meldal and K. Barry Sharpless “for the development of click chemistry and bioorthogonal chemistry.”
Image from The Nobel Prize (@NobelPrize)
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Undergraduates looking toward graduate school in the chemical & biological sciences can meet @scrippsresearch reps next week at the events listed below & at scripps.edu/gradschool. Meet us in-person at @virginia_tech, @Penn, @williamandmary or virtually at several others.
Image from Scripps Research Graduate Program (@ScrippsGradPrgm)
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Francisco Martinez-Pena retweeted
Sendurai Mani (@SenduraiMani) profile picture
Sendurai Mani@SenduraiMani22 Sep 2022
I will be giving a talk @ an outstanding @AACR Special Conference on Cancer Metastasis, chaired by @FAndreMD @SJMorrison_, Danny Welch & Zena Werb with a spectacular set of speakers #AACRmet22. (Nov 14-17, Portland, Oregon), Additional information: bit.ly/3DIUZ9M
https://t.co/wjMy6Z20cd

ALT https://t.co/wjMy6Z20cd

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Francisco Martinez-Pena retweeted
Madeline E. Kavanagh (@mads_chem) profile picture
Madeline E. Kavanagh@mads_chem12 Sep 2022
A resurgence of allosteric inhibitors! Check out the Cravatt lab @scrippsresearch and @VividionRx selective, #covalent #allosteric JAK1 inhibitor rdcu.be/cVqZZ, and the recently approved allosteric TYK2 inhibitor! @bmsnews bit.ly/3QvVWEP
Image from Madeline E. Kavanagh (@mads_chem)
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Very grateful to participate in this amazing work that uses a DEEP LEARNING model to discover highly synergistic drug combinations, with @wildtypehuman, @Mila_Quebec, @RelationRx, and @scrippsresearch
Jake P. Taylor-King (@wildtypehuman) profile pictureJake P. Taylor-King
@wildtypehuman8 Sep 2022
Updated RECOVER manuscript out, 2 key updates: 1.) More experiments: 5 rounds of Active Learning guided experimentations 2.) Analysis of learnt embeddings: co-embedding of structure with biological mechanism. arxiv.org/abs/2202.04202
Image from Jake P. Taylor-King (@wildtypehuman)
Image from Jake P. Taylor-King (@wildtypehuman)
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Francisco Martinez-Pena retweeted
Jose Pedro Cerón (@jpcer0n) profile picture
Jose Pedro Cerón@jpcer0n18 Aug 2022
My paper on #docking and #virtualscreening for #SARSCoV2 now highlighted on the Front Cover of @ChemMedChem! @cudsanjavier @UPCTnoticias #compchem #falsetheoreticalfriends chemistry-europe.onlinelibra…
Front Cover: When Virtual Screening Yields Inactive Drugs: Dealing with False Theoretical Friends...

Front Cover: When Virtual Screening Yields Inactive Drugs: Dealing with False Theoretical Friends...

The Front Cover illustrates how computational models open the door to the search for novel drugs, including antivirals, in vast chemical spaces with billions of compounds. However, the use (and...

chemistry-europe.onlinelibrary.wiley.com
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Francisco Martinez-Pena retweeted
Alessio Ciulli (@alessiociulli) profile picture
Alessio Ciulli@alessiociulli27 Aug 2022
Happy to see this out in press now @J_A_C_S pubs.acs.org/doi/10.1021/jac…
Discovery of XL01126: A Potent, Fast, Cooperative, Selective, Orally Bioavailable, and Blood–Brain...

Discovery of XL01126: A Potent, Fast, Cooperative, Selective, Orally Bioavailable, and Blood–Brain...

Abstract. Leucine-rich repeat kinase 2 (LRRK2) is one of the most promising targets for Parkinson’s disease. LRRK2-targeting strategies have primarily focu

pubs.acs.org
Alessio Ciulli (@alessiociulli) profile pictureAlessio Ciulli@alessiociulli23 May 2022
Excited to debut XL01126 – a first-in-class PROTAC degrader for the protein kinase LRRK2, a high-profile target in Parkinson’s disease. Great #CeTPD collaboration with Dario Alessi @mrcppu team and @RuiMoreira_UL Please share, thread below doi.org/10.26434/chemrxiv-20…
Image from Alessio Ciulli (@alessiociulli)
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Francisco Martinez-Pena retweeted
Andrew Caprariello (@AVCapLab) profile picture
Andrew Caprariello@AVCapLab23 Aug 2022
Wondering what’s new with drug development for repairing #myelin in #MultipleSclerosis and related disorders? Our new review will get you caught up. Hot off the press! nature.com/articles/s41589-0…
The landscape of targets and lead molecules for remyelination

The landscape of targets and lead molecules for remyelination

Nature Chemical Biology - Loss of myelin causes neurological symptoms for patients with multiple sclerosis. This Perspective details how phenotypic screening has accelerated discovery efforts...

nature.com
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