@FuYiben

A postdoc in the Johns Hopkins, major in Biophysics. Now studying Clathrin assemblies and membrane models with theoretical modeling and simulations.

 The Johns Hopkins University
Joined February 2020
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Excited we have two new papers out on the self-assembly and remodeling dynamics of the HIV Gag lattice in @biophysJ and @eLife ! Both papers combine reaction-diffusion modeling with theory and experiment doi.org/10.7554/eLife.84881 authors.elsevier.com/a/1hPKi…

Structure of the HIV immature lattice allows for essential lattice remodeling within budded virions

Proteins locked into the immature HIV lattice can exploit its incomplete structure to form the essential protease dimer needed for viral maturation.

elifesciences.org
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Here's our 'Current Opinion' with @FuYiben on Modeling how protein assemblies remodel membranes: authors.elsevier.com/a/1gG4x… part of a special issue edited by @VothGroup
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Our paper is out in J Chem Phys: Speed limits of protein assembly with reversible membrane localization. We show how and when assembly can be much faster on membranes despite slower diffusion, thanks to postdoc Bhavya Mishra for leading this!! aip.scitation.org/doi/10.106…
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In this new preprint, we use a continuum membrane model to predict how insertion of amphipathic helices drives preferential binding to curved membranes. from super post-doc @FuYiben and expert collabs @ZenoResearch and @StachowiakLab biorxiv.org/content/10.1101/…

A continuum membrane model predicts curvature sensing by helix insertion

Protein domains, such as ENTH (Epsin N-terminal homology) and BAR (bin/amphiphysin/rvs), contain amphipathic helices that drive preferential binding to curved membranes. However, predicting how the...

biorxiv.org
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Our new paper: A continuum membrane model predicts curvature sensing by helix insertion.Thanks to my PI Prof Margaret Johnson and our collaborators Prof Jeanne Stachowiak and Prof Wade Zeno! And also thanks to Dr Alexander Sodt and Prof Brian Camley. biorxiv.org/content/10.1101/…

A continuum membrane model predicts curvature sensing by helix insertion

Protein domains, such as ENTH (Epsin N-terminal homology) and BAR (bin/amphiphysin/rvs), contain amphipathic helices that drive preferential binding to curved membranes. However, predicting how the...

biorxiv.org
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In a new preprint, we show that clathrin-coated structures formed on membranes will spontaneously disassemble without sufficient adaptor proteins. Thanks to my awesome postdoc Sikao Guo and membraneExpert @AlexSodt biorxiv.org/content/10.1101/…

Nascent clathrin lattices spontaneously disassemble without sufficient adaptor proteins

Clathrin-coated structures must assemble on cell membranes to perform their primary function of receptor internalization. These structures show marked plasticity and instability, but what conditions...

biorxiv.org
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