@GreedyApple

Postdoctoral research fellow

 New York City, New York
Joined February 2010
  • Tweets214
  • Following321
  • Followers118
🚨We are looking for a highly motivated and curious PhD candidate with a strong interest in biology, computational methods, and theory to work on the problem of antibiotic resistance evolution 🤓🧫✨ Apply by Sep 18! 🚀 humantechnopole.it/en/news/1…

17 fully funded PhD positions now open at Human Technopole - Human Technopole

Open your mind. Grow your talent. Shape your future in science with the HT PhD Programme. Human Technopole is offering fully funded PhD positions for talented and motivated graduates who want to...

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Angelica Parente
@draparenteAug 17
Finally get to say that a drug I helped discover is in human trials. The team sprinted for 6 years on this. We went from a thought-to-be undruggable target to profound degradation very quickly, and then several more years optimizing for human dosing. That speaks to the power of DNA encoded libraries and modularity of TPD, and the hard road that is drug *development*. ir.nurixtx.com/news-releases…

Nurix Announces $10 Million Milestone Payment Associated with Initiation of a Phase 1 Clinical...

Oral STAT6 degrader advances into clinical development for type 2 inflammatory diseases Nurix has earned approximately $139 million to date under its collaboration with Sanofi and remains eligible to...

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Karuna Ganesh@KarunaMDPhDAug 5
Thrilled to share our latest work is out today in @Nature ZFP36L2 orchestrates stress-adaptive plasticity in regeneration and cancer. nature.com/articles/s41586-0…

ZFP36L2 orchestrates stress-adaptive plasticity in regeneration and cancer

Nature - The RNA-binding protein ZFP36L2 mediates stress-adaptive plasticity in intestinal regeneration and colorectal cancer metastasis.

nature.com
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Eli Weinstein@EliWeinstein6Jul 8
Our new preprint pushes causal machine learning into new scientific domains using probabilistic symmetry and geometry.
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Karuna Ganesh@KarunaMDPhDMay 26
We are thrilled to share our latest work out today @Dev_Cell! Appendiceal adenocarcinoma (AC) is a rare, aggressive cancer that frequently spreads to the peritoneum. Until now, lack of robust preclinical models has severely limited drug discovery. cell.com/developmental-cell/…🧵👇 🔗

An appendiceal cancer organoid biobank identifies phenotypic evolution and druggable dependencies...

Mahmoud et al. establish a stable organoid biobank from primary appendiceal cancer and paired peritoneal metastases. They reveal that metastases are dedifferentiated and resistant to standard...

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We are looking for a highly motivated and curious PhD candidate with a strong interest in biology, computational methods, and theory 🧫 📊 🤓 Join us to work on ecological and evolutionary processes in bacteria and beyond! Apply by March 26th! 🏃‍♀️ 🏃‍♂️ humantechnopole.it/en/news/4…

4 PhD Positions in Data Analytics and Decision Sciences at Human Technopole - Human Technopole

Are you passionate about AI, mathematical modelling, or genomics, and eager to work on high-impact research in biomedical science? Human Technopole is excited to offer four fully-funded PhD positions...

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Ming "Tommy" Tang@tangming2005Mar 18
1/ I'm a bioinformatian who uses Claude (and code) every day. Most people use it like a search engine. Anthropic quietly published a page that shows you what you're actually missing.
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Manufacturing-aware generative models enable petascale synthesis of designed DNA go.nature.com/3NxXt1I
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Our paper on variational synthesis is out now in Nature Biotechnology. Manufacturing-aware generative models — AI architectures that know how to physically build their own designs — enabling synthesis of DNA encoding ~10^16 AI-designed proteins at a cost that would be roughly a quadrillion dollars using conventional methods.
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Jake June-Koo Lee@jakelee0711Feb 16
1/n Have you ever wondered whether an amplified oncogene in a patient’s tumor (HER2/EGFR/CCND1/…) is carried on extrachromosomal DNA (ecDNA) vs embedded within a chromosome? Bulk WGS + genome graph can hint, but in practice it’s often hard to resolve. Here is our new preprint.
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Today marks a meaningful milestone -- I am starting as a lab investigator @CompOncMSK and thoracic oncologist @MSK_DeptOfMed, focused on improving treatment through a deep understanding of cancer evolution. I'll soon be looking for fellow travelers on this mission. Stay tuned!
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Excited that this is out in @PNASNews ! pnas.org/doi/10.1073/pnas.24… In a sentence, we show that different mutational processes can have different long-term impacts on eco-evolutionary systems. 1/n

Trait-space patterning is dictated by the tempo and mode of mutation | PNAS

In large, natural ecosystems, many (≳1) phenotypically relevant mutants can emerge over the characteristic turnover time of the population. When th...

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Part 2 of our combined efforts with @SohrabShah and @VStrongMD to understand immune evasion in gastric cancer describes the work in this preprint, led by @GreedyApple and Emily Stroobant in a brilliant collaboration: biorxiv.org/content/10.1101/…

Disrupted priming within draining lymph nodes drives immune quiescence in gastric cancer

The gastric mucosa is characterized by continuous innate immune surveillance and inflammatory signaling, yet a high proportion of gastric carcinomas (GCs) are recalcitrant to immune-directed therap...

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Awesome opportunity to work with the rising star of this field in an exciting team!
Ed Reznik@EdReznik11 Jun 2024
Hello Xverse, we're on the hunt for a postdoctoral fellow to study cellular and systemic metabolism with a quantitative, multimodal toolkit. Is this you or someone you know and love? Reach out!
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Congratulations to my Cambridge colleague Shankar Balasubramanian, his colleagues David Klenerman and Pascal Mayer on the award of a Canada Gairdner International award for their invention of short read massively parallel DNA sequencing. gairdner.org/winners
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Portal@_portal_23 Jan 2024
This week at CARE, Gemma Morgan will present "Identifiable Deep Generative Models via Sparse Decoding". 📅 When: Thursday from 11am - 12pm ET 📝 Read the paper: openreview.net/forum?id=vd0o… Tune in live: portal.valencelabs.com/event…
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I’m very excited about my new paper with @blei_lab : Hierarchical Causal Models Preprint: arxiv.org/abs/2401.05330 Talk: youtube.com/watch?v=ovOVaNMx…

Hierarchical Causal Models

Causal questions often arise in settings where data are hierarchical: subunits are nested within units. Consider students in schools, cells in patients, or cities in states. In these settings,...

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1/🧵 Excited to share #Decipher 🔍, a game-changing method for integrating #singlecell RNA-seq data 🧬 from multiple conditions and revealing cell-state transitions in diseases like #AML. Dive into our thread for more! Check our preprint for full details. biorxiv.org/content/10.1101/…
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The GCI would like to congratulate this year's Carraressi Foundation OVCARE Grant Recipients– Dr. Amal El-Naggar, Dr. Farhia Kabeer, and Dr. Bengul Gokbayrak! Learn more about their funded projects here ⏩: buff.ly/3KJW5EA @BCCancer @VCHhealthcare
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updated ICML version! openreview.net/pdf?id=8LdBTj…
Alan Amin@AlanNawzadAmin26 Jul 2023
While you’re at #ICML2023 check out our work with @EliWeinstein6 and @deboramarks! In it we build an absolute and inexpensive measure of discrepancy between generative models and observations of biological sequences. icml.cc/virtual/2023/poster/…, openreview.net/forum?id=fvBV…
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