Human Obesity Metabolism (HOMe) Lab (@HOMeScienceLab) header
Human Obesity Metabolism (HOMe) Lab (@HOMeScienceLab) profile picture

Human Obesity Metabolism (HOMe) Lab

@HOMeScienceLab

A Research Group (Christos Katsanos, PhD, PI) at Arizona State University investigating the biology behind muscle health impairments in humans with obesity.

 Phoenix, Arizona
Joined October 2023
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Our review in Comprehensive Physiology with @DrZhenqiLiu and Philip Atherton discusses evidence that GLP-1 RAs may improve muscle vascular function and glucose metabolism, while outlining the unresolved questions around muscle protein metabolism. onlinelibrary.wiley.com/doi/…
Glucagon‐Like Peptide‐1 Receptor Agonism and Muscle Health: Vascular and Myocellular Effects on...

Glucagon‐Like Peptide‐1 Receptor Agonism and Muscle Health: Vascular and Myocellular Effects on...

Glucagon-like Peptide-1 Receptor Agonism Through Enhancing Muscle Vasculature Function Facilitates Glucose Uptake and Protein Metabolism in Skeletal Muscle.

onlinelibrary.wiley.com
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Human Obesity Metabolism (HOMe) Lab retweeted
Rasmussen Lab (@TheRasmussenLab) profile picture
Rasmussen Lab@TheRasmussenLabNov 6
Congratulations to Erik Marchant on his new paper in Aging Cell! 🎉 In this work from his dissertation, Erik shows that mTORC1 activation is sufficient to drive pro-inflammatory changes in aged muscle. onlinelibrary.wiley.com/doi/…
Constitutive Activation of Skeletal Muscle mTORC1 Drives Pro‐Inflammatory Gene Expression in...

Constitutive Activation of Skeletal Muscle mTORC1 Drives Pro‐Inflammatory Gene Expression in...

mTORC1 activity increases with aging and may contribute to skeletal muscle decline. In aged mice, muscle-specific Depdc5 knockout activated mTORC1, increased inflammatory and immune-related mRNA...

onlinelibrary.wiley.com
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Great representation of our HOMe Lab at this year’s #AZPS2026! Great job, Kailin, Molly, and Isabela!
Image from Human Obesity Metabolism (HOMe) Lab (@HOMeScienceLab)
Image from Human Obesity Metabolism (HOMe) Lab (@HOMeScienceLab)
Image from Human Obesity Metabolism (HOMe) Lab (@HOMeScienceLab)
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Human Obesity Metabolism (HOMe) Lab retweeted
Abigail Mackey (@AbigailMackey1) profile picture
Abigail Mackey@AbigailMackey1Oct 8
New @ISMCopenhagen publication with Casper @Soendenbroe on human muscle fibre type remodelling with age and exercise🏃💪 Nice to see such simple observations still have value! #myotwitter link.springer.com/article/10…
MyHC–SERCA mismatch as a marker of fiber-type remodeling in aging human skeletal muscle

MyHC–SERCA mismatch as a marker of fiber-type remodeling in aging human skeletal muscle

Skeletal Muscle - Skeletal muscle fibers are commonly classified according to myosin heavy chain (MyHC) isoform, but fiber-type identity also involves coordinated expression of calcium-handling...

link.springer.com
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Human Obesity Metabolism (HOMe) Lab retweeted
Zhenqi Liu, MD (@DrZhenqiLiu) profile picture
Zhenqi Liu, MD@DrZhenqiLiuSep 24
The Ozempidemic — is social media telling the full story? cavalierdaily.com/article/20…
The Ozempidemic — is social media telling the full story?

The Ozempidemic — is social media telling the full story?

To strain the surplus of information about GLP-1 medication circulating on social media, The Cavalier Daily spoke to those on the frontlines of the phenomenon — University medical professionals and a...

cavalierdaily.com
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Thankful to #ECSS2026 for the opportunity and proud of our graduate student, Kailin, for sharing our initial findings on #muscle mass responses in patients at Mayo Clinic Arizona.
Image from Human Obesity Metabolism (HOMe) Lab (@HOMeScienceLab)
Image from Human Obesity Metabolism (HOMe) Lab (@HOMeScienceLab)
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Great opportunity for our lab to have been joined by @MartaMurgia and @Phil_Bellinger in this symposium at this year's #ECSS2026!
Image from Human Obesity Metabolism (HOMe) Lab (@HOMeScienceLab)
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Human Obesity Metabolism (HOMe) Lab retweeted
Konstantinos Prokopidis (@KostasProko) profile picture
Konstantinos Prokopidis@KostasProkoApr 27
Shaping the future of muscle health: A clinical nutrition perspective and research agenda clinicalnutritionjournal.com…
Image from Konstantinos Prokopidis (@KostasProko)
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Great job by Kailin Johnsson , PhD student, presenting research from our @HOMeScienceLab at #APS2026 2 presentations, 3 separate awards Congratulations, Kailin!
Image from Human Obesity Metabolism (HOMe) Lab (@HOMeScienceLab)
Image from Human Obesity Metabolism (HOMe) Lab (@HOMeScienceLab)
Image from Human Obesity Metabolism (HOMe) Lab (@HOMeScienceLab)
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Kjirstin from our lab getting ready to present her research on the effects of high fat diet on muscle fiber types this afternoon at #APS2026!
Image from Human Obesity Metabolism (HOMe) Lab (@HOMeScienceLab)
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Human Obesity Metabolism (HOMe) Lab retweeted
David Morales-Álamo (@D_Morales_Alamo) profile picture
David Morales-Álamo@D_Morales_AlamoApr 1
New in PNAS: Age-related muscle decline is driven by mitochondrial dysfunction—but exercise can remodel mitochondria, restore muscle function, and reduce frailty, even later in life. pnas.org/doi/10.1073/pnas.25…
Mitochondrial remodeling in skeletal muscle underlies exercise-induced reversal of age-associated...

Mitochondrial remodeling in skeletal muscle underlies exercise-induced reversal of age-associated...

Loss of skeletal muscle mass and strength are common manifestations of frailty in older people and are linked to reduced quality of life. However, ...

pnas.org
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Human Obesity Metabolism (HOMe) Lab retweeted
Christopher Fry (@ChrisFryPhD) profile picture
Christopher Fry@ChrisFryPhDMar 27
Back-to-back papers from @AlexKeeble5 and @saragonzalezve . Working with @MVFranchi , we show that limb suspension and post-ACLR muscle exhibit fundamentally different muscle transcriptomic signatures. journals.physiology.org/doi/…
Image from Christopher Fry (@ChrisFryPhD)
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Henning Langer (@HenningLanger) profile picture
Henning Langer@HenningLangerMar 18
Super proud to share the first original research paper from my new lab: "Weight loss with GLP-1 medicines does not result in a disproportionate loss of muscle mass or function in obese mice and humans" cell.com/cell-reports-medici…
Weight loss with GLP-1 medicines does not result in a disproportionate loss of muscle mass or...

Weight loss with GLP-1 medicines does not result in a disproportionate loss of muscle mass or...

Langer et al. show that GLP-1 medicines mildly reduce absolute muscle mass but improve relative mass and running performance in mice. Despite similar changes to body weight, GLP-1RA affects the...

cell.com
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Incretin-based therapies exert distinct, time and dose-dependent effects on skeletal muscle mitochondrial function onlinelibrary.wiley.com/shar…
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Human Obesity Metabolism (HOMe) Lab retweeted
Craig A. Goodman (@CraigAGoodman1) profile picture
Craig A. Goodman@CraigAGoodman1Mar 19
Weight loss with GLP-1 medicines does not result in a disproportionate loss of muscle mass or function in obese mice and humans cell.com/cell-reports-medici…
Weight loss with GLP-1 medicines does not result in a disproportionate loss of muscle mass or...

Weight loss with GLP-1 medicines does not result in a disproportionate loss of muscle mass or...

Langer et al. show that GLP-1 medicines mildly reduce absolute muscle mass but improve relative mass and running performance in mice. Despite similar changes to body weight, GLP-1RA affects the...

cell.com
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Human Obesity Metabolism (HOMe) Lab retweeted
American Physiological Society (@APSPhysiology) profile picture
American Physiological Society@APSPhysiologyMar 20
We're happy to announce we've achieved our #Subscribe2Open goal in 2026! Ten of our @APSPublications primary research journals will be open to readers worldwide with no article processing charges for authors. Learn more: ow.ly/Ungf50YwORt
Colorful abstract ear shape next to the text 'aps subscribe to open' with an open lock icon integrated into the word 'open'.

ALT Colorful abstract ear shape next to the text 'aps subscribe to open' with an open lock icon integrated into the word 'open'.

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David J Glass MD (@davidjglassMD) profile picture
David J Glass MD
@davidjglassMDMar 16
A very important point is the safety point: this paper shows you can significantly decrease myostatin levels throughout a person’s lifetime, and the result is more muscle, less fat, increased strength, and no noticeable side effects
David J Glass MD (@davidjglassMD) profile pictureDavid J Glass MD
@davidjglassMDMar 16
Humans with function-disrupting variants in the myostatin gene (MSTN) have increased skeletal muscle mass and strength, and less adiposity nature.com/articles/s41467-0…
Humans with function-disrupting variants in the myostatin gene (MSTN) have increased skeletal...

Humans with function-disrupting variants in the myostatin gene (MSTN) have increased skeletal...

Nature Communications - This multi-cohort study reports genetic variants in myostatin associated with increased muscle mass, strength, and reduced adiposity. These findings support long-term...

nature.com
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Combining Non-Invasive Tests of Different Physiological... : Medicine & Science in Sports & Exercise journals.lww.com/acsm-msse/a…
Combining Noninvasive Tests of Different... : Medicine & Science in Sports & Exercise

Combining Noninvasive Tests of Different... : Medicine & Science in Sports & Exercise

VAN DE CASTEELE, F., L. VAN DER MEULEN, M. SABLAIN, R. VAN THIENEN, E. LIEVENS, and W. DERAVE. Combining Noninvasive Tests of Different Physiological...

ovid.com
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Mitigating loss of lean muscle in GLP-1 and dual GLP-1/GIP agonists: P... sciencedirect.com/science/ar…
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Fibre Type–Specific Proteomics Reveals Shared and Distinct Skeletal Muscle Adaptations to Resistance Training and Beta2‐Adrenergic Agonist - Jessen - 2026 - Journal of Cachexia, Sarcopenia and Muscle - Wiley Online Library onlinelibrary.wiley.com/doi/…
Fibre Type–Specific Proteomics Reveals Shared and Distinct Skeletal Muscle Adaptations to Resista...

Fibre Type–Specific Proteomics Reveals Shared and Distinct Skeletal Muscle Adaptations to Resista...

Background Skeletal muscle is essential for metabolic health and physical function. While resistance training promotes muscle hypertrophy, alternative therapeutic strategies are needed for individu...

onlinelibrary.wiley.com
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