Alex Hall Hickman (@HallHickman) header
Alex Hall Hickman (@HallHickman) profile picture

Alex Hall Hickman

@HallHickman

A post-grad researcher investigating the regulatory effects of G-quadruplex RNA on chromatin - Regulatory Genomics Group - UCL Cancer Institute

 UCL
Joined October 2020
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Seems like highlighting molecular biology artefacts is a real trend for publications in 2024. Pleased to share @RegGenomics and I's work on the role of RNA in PRC2 recruitment @CellReports. cell.com/cell-reports/fullte…
Apparent RNA bridging between PRC2 and chromatin is an artifact of non-specific chromatin precipi...

Apparent RNA bridging between PRC2 and chromatin is an artifact of non-specific chromatin precipi...

The reduced detection of PRC2 target sites upon the addition of RNase A to chromatin immunoprecipitation experiments suggests the existence of RNA bridges that connect PRC2 to chromatin. Hall Hickman...

cell.com
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Alex Hall Hickman retweeted
Gabriel Zucman (@gabriel_zucman) profile picture
Gabriel Zucman
@gabriel_zucmanJun 26
Together with my colleague Emmanuel Saez, we’ve spent years working alongside California's civil society to make the 200 Silicon Valley billionaires—including Mark Zuckerberg and Peter Thiel—pay their fair share. Today, they have just lost a crucial battle.
Image from Gabriel Zucman (@gabriel_zucman)
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In our new paper aided by single molecule imaging of RNA and transcription machinery we demonstrate how Polycomb Repressive Complex (PRC) represses transcription in live cells 🧵 nature.com/articles/s41556-0… 1/9
The Polycomb system sustains promoters in a deep OFF state by limiting pre-initiation complex...

The Polycomb system sustains promoters in a deep OFF state by limiting pre-initiation complex...

Nature Cell Biology - Combining degron-based depletion with live-cell transcription imaging and single-particle tracking, Szczurek et al. show that Polycomb keeps promoters in an OFF state by...

nature.com
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Jeannie Lee (@XistHarvard) profile picture
Jeannie Lee@XistHarvard20 Sep 2024
Re-analysis of CLAP data affirms PRC2 as an RNA binding protein and XIST RNA as a target. We (YongWoo Lee, Roy Blum, Michael Rosenberg) examined the datasets of Guo et al. (PMID 38387462 - which reported that PRC2 is not an RBP) ... biorxiv.org/content/10.1101/…
Image from Jeannie Lee (@XistHarvard)
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Cell Reports (@CellReports) profile picture
Cell Reports@CellReports29 Feb 2024
Apparent RNA bridging between PRC2 and chromatin is an artifact of non-specific chromatin precipitation upon RNA degradation dlvr.it/T3R1Wn
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Chen Davidovich (@DavidovichLab) profile picture
Chen Davidovich@DavidovichLab28 Feb 2024
1/ Is RNA essential for PRC2 chromatin occupancy? Here we refute evidence that was previously used to support this idea. Work by @evan_healy4 and @QiZhang85 from the @DavidovichLab, @MonashBDI, @EMBLAustralia. cell.com/cell-reports/fullte…
The apparent loss of PRC2 chromatin occupancy as an artifact of RNA depletion

The apparent loss of PRC2 chromatin occupancy as an artifact of RNA depletion

Healy et al. demonstrate that RNase A treatment of chromatin during immunoprecipitation leads to the artificial loss of all facultative heterochromatin. This observation can be explained by a gain in...

cell.com
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cricket.com.au (@cricketcomau) profile picture
cricket.com.au
@cricketcomau28 Jan 2024
Every angle, every call – how the broadcasters celebrated Shamar Joseph and the West Indies' historic Gabba win #AUSvWI
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Alex Hall Hickman retweeted
Adrian Bracken (@adrianbracken) profile picture
Adrian Bracken@adrianbracken17 Oct 2023
Really looking forward to our next @irelandchrom webinar on Friday Nov 3rd at 4pm GMT / 5pm CET. Richard Jenner @RegGenomics from @UCL will speak on ‘Understanding the effects of RNA on PRC2 and other chromatin regulators’. Please register at: lnkd.in/enJPyet6
Image from Adrian Bracken (@adrianbracken)
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Richard Jenner (@RegGenomics) profile picture
Richard Jenner@RegGenomics5 Oct 2023
Congratulations to @HallHickman for winning best poster @BiochemSoc Transcription and Chromatin for his work on PRC2 and RNA!
Image from Richard Jenner (@RegGenomics)
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What a wonderful couple days of science 🧬 Huge thanks to @doctorconnor, @PradeepMadapura and Sonia Rocha for organising such an enjoyable symposium! @BiochemSoc #BiochemEvent
Pradeepa Madapura (@PradeepMadapura) profile picturePradeepa Madapura@PradeepMadapura5 Oct 2023
Congratulations to @andreannafw and @HallHickman for winning @QMULepigenetics sponsored poster prizes at @BiochemSoc #biochemEvent on chromatin & transcription
Image from Pradeepa Madapura (@PradeepMadapura)
Image from Pradeepa Madapura (@PradeepMadapura)
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Faraz K Mardakheh (@FKHM) profile picture
Faraz K Mardakheh@FKHM23 Aug 2023
Replying to @RegGenomics @HallHickman
Congratulations Richard and team! Really important work!
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Chen Davidovich (@DavidovichLab) profile picture
Chen Davidovich@DavidovichLab18 Aug 2023
You were told that RNA is essential for PRC2 chromatin occupancy. We examined key evidence that previously supported this idea: it's an artefact.🧵 biorxiv.org/content/10.1101/…
The apparent loss of PRC2 chromatin occupancy as an artefact of RNA depletion

The apparent loss of PRC2 chromatin occupancy as an artefact of RNA depletion

RNA has been implicated in the recruitment of chromatin modifiers, and previous studies have provided evidence in favour and against this idea. RNase treatment of chromatin is a prevalent tool for...

biorxiv.org
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Excellent descriptive from Richard (@RegGenomics) detailing our work highlighting the loss of PRC2 chromatin occupancy under rChIP conditions as a symptom of non-specific chromatin precipitation. Please also check out the parallel study from @DavidovichLab @evan_healy4 @QiZhang85
Richard Jenner (@RegGenomics) profile pictureRichard Jenner@RegGenomics18 Aug 2023
1/8 Our new pre-print from @HallHickman is out biorxiv.org/cgi/content/shor… We report that the apparent RNA bridging between PRC2 and chromatin observed by Long et al 2020 using rChIP is an artefact of non-specific chromatin precipitation Please alert colleagues using this method!🧵
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Lab Life: When your PhD (almost) falls apart doi.org/10.7554/eLife.81548

Lab Life: When your PhD (almost) falls apart

As a chance observation threatens to unravel several years of work, a PhD student must choose what to do next.

elifesciences.org
Alex Hall Hickman retweeted
Ben Nacev, MD PhD (@BenNacev) profile picture
Ben Nacev, MD PhD@BenNacev9 Jun 2022
Really great mechanistic work to understand PRC2 dysregulation by a common fusion protein in endometrial stromal #sarcoma. Congrats @Manuel_TavaresC . We need more like this! JAZF1-SUZ12 dysregulates PRC2 function and gene expression during cell... sciencedirect.com/science/ar…
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Richard Jenner (@RegGenomics) profile picture
Richard Jenner@RegGenomics9 Feb 2022
Just a reminder there is one more week to apply to the #postdoc position available in my lab to work on the effects of nascent RNA on chromatin at @uclcancer Please see: atsv7.wcn.co.uk/search_engin…
Richard Jenner (@RegGenomics) profile pictureRichard Jenner@RegGenomics27 Jan 2022
We have a postdoc position available! If you’re interested in #RNA or #chromatin and especially both together then please apply! Deadline Feb 16th. Link:atsv7.wcn.co.uk/search_engin… Please retweet!
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