Physician-Scientist, Hematologist, Transfusion Medicine Specialist @MassGenBrigham @HarvardMed | Hemostasis, Thrombosis, Glycobiology
Boston, MA
Joined October 2018
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Thanks for highlighting our commentary on this interesting study! @jacobranderso
In areas with high prevalence of tick-induced alpha-gal syndrome, patients with blood type O appeared to be at significantly increased risk for allergic transfusion reactions to B or AB blood units, according to a retrospective cohort study. @HollenhorstM
medpagetoday.com/infectiousd…
Thanks for supporting and highlighting my lab's research @isth
🎙️ New ISTH Pulse Podcast Episode: What does it take to turn fundamental science into real advances in patient care? Our host sits down with Marie Hollenhorst to discuss her path into thrombosis and hemostasis research.
Listen: soundcloud.com/isth_thepulse…
It was fund working with @jacobranderso to put together these images highlighting how a key finding from the peripheral blood smear - double bite cells - led to a diagnosis of oxidant hemolysis. #hematology
Double bite cells on peripheral blood smear helped establish the diagnosis of oxidant #hemolysis due to recreational alkyl nitrite use in a man with normal G6PD
doi.org/10.1002/ajh.70035 #hematology
Marie Hollenhorst, MD, PhD retweeted
Two novel lamprey MoAbs highly specific for the H type and H type II antigens allow to study the function and expression of H type II antigens in various N- and O-glycans.
tinyurl.com/5n8kwb2e
#glycotime
Marie Hollenhorst, MD, PhD retweeted
A labor of love! Excited to see this online first. #amyloidosis. It was a treat to collaborate with many friends: @KleinLabHMS, Ray Comenzo, Mario Nuvolone, @nickbolli, Joao Paulo @GygiLab. Thanks @BloodPortfolio! ashpublications.org/blood/ar…
Great to see this paper published!
Lucky to have first author Muataz Hamad as a postdoc in my lab. My whole lab has learned a lot about reticulated platelets from him!
New publication! 🆕🎉
Still using thiazole orange to ID reticulated platelets in mouse blood? Hamad et al. (2025) present a novel & reproducible FC method using SYTO 13—no harsh washes, minimal activation.
🔗 tinyurl.com/ekemunrj
#platelets #flowcytometry #SYTO13
ALT Adapted from Figure 4. Analysis of the surface activation marker P-selectin (CD62P) in platelets stained with SYTO 13, in both their resting and stimulated states. From Hamad, et al. (2025), https://doi.org/10.1080/09537104.2025.2489020.
Beta-2-glycoprotein I is a target of autoantibodies in the antiphospholipid antibody syndrome.
Is this protein prothrombotic in vivo?
I enjoyed writing this commentary highlighting a recent paper by Kulkarni et al focused on this question. doi.org/10.1182/blood.202502…
Thorough analyses of the intestinal microbiome composition of the mice used these studies would help to advance understanding of potential microbiome contributions to the observed phenotypes. ow.ly/UHC550VLGBl #thrombosisandhemostasis
Marie Hollenhorst, MD, PhD retweeted
A mother dies every 2 minutes due to undetected pregnancy complications, like severe bleeding and preeclampsia. With timely care, these deaths are preventable. We join the @WHO in urging leaders to invest in maternal and child health. #HealthForAll
So excited to host Dr. Silvia Zheng in my lab this summer. Thank you @isth for your support!
Meet ISTH Training Fellow: Dr. Silvia Zheng!✨
Dr. Zheng is headed to Boston for her 2025 ISTH Training Fellowship! She’ll explore immune-mediated platelet glycoprotein alterations with Marie Hollenhorst, a 2024 FRCDA winner!
🔔Early-career researchers: Apply for FRCDA by March 3!
🔗Learn more about Dr. Zheng: isth.org/news/news.asp?id=69…
Marie Hollenhorst, MD, PhD retweeted
Congratulations to all of the lab members who worked hard on this recent review shedding light on the fascinating interplay between ABO blood groups & galectins! #TransfusionMedicine #Immunology #Galectins #ABOAntigens
pubmed.ncbi.nlm.nih.gov/3940…
Marie Hollenhorst, MD, PhD retweeted
Hey there, O-glyco enthusiasts! Do you use PNGaseF before your glycoproteomics runs? If so, you might want to check for "free" N-glycans hanging around in your sample. Check out @VRAdoesMS and @joann_chong's new preprint: 10.26434/chemrxiv-2024-568nn
Marie Hollenhorst, MD, PhD retweeted
Hard to compete with the Nobel prizes (!!!) today but proud to share our preprint (by a fun team of @TheSpenceLab, Ansley Conchola, Tristan Frum + many others) where we present a cellularly-resolved map of the developing human lung, identifying a human-specific LGR5+ basal cell.
Excited to share our latest preprint:
A spatially-resolved blueprint of the developing human lung reveals a WNT-driven niche for basal stem cells.
biorxiv.org/content/10.1101/…
Led by a talented team: @PeggyPHsu, Tristan Frum and Ansley Conchola - and with many other contributors!
Thanks @isth for this award! Excited to use these funds to support new projects in the Hollenhorst lab. @BrighamHeme
ISTH Bangkok 2024: The magnificent three: Congrats to Stijn, Yohei, and Marie on their fundamental research career development award and wishing them a brilliant future. @CARIMMaastricht @isth
Thanks #ISTH2024 for the opportunity to present this work, led by former Hollenhorst lab research assistant Adede Appah-Sampong, in collaboration with @StacyMalaker @PepiDoesScience @theNCFG and colleagues.
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I will miss having you as an office neighbor, @MullallyLab! Thanks for all of your help and advice as I got my lab off the ground. I wish you all the best at Stanford.
Thanks to all the wonderful mentors, colleagues, trainees & admin staff I've worked with @BrighamHeme, fun party last week, I will miss you all! @vangalenlab @NTConnell @MaureenAchebe @joanhowMD @TheBianchiLab @SandraMcAllist4 @adamssperling @KoduriLab @HollenhorstM @connors_md
Marie Hollenhorst, MD, PhD retweeted
This Bleeding Disorders Awareness Month, meet an AABB changemaker!
Patricia Zerra, MD, received an #AABBFoundation grant to study complications in #hemophilia treatment. We spoke with Zerra about her career, research and advice for new investigators. bit.ly/4aoRTVr
Marie Hollenhorst, MD, PhD retweeted
We're ecstatic to welcome Ann Mullally (@MullallyLab) to #StanDOM as a professor of medicine & the new division chief of #Hematology! She is known as a passionate advocate for #TeamScience & #PhysicianScientists in medicine!
Marie Hollenhorst, MD, PhD retweeted
Harvard Medical School Technical Research Assistant: Hollenhorst Lab @HollenhorstM
#glycotime #platelets Research assistant position available in the Hollenhorst Lab at Brigham and Women's Hospital and Harvard Medical School.
jobrxiv.org/job/brigham-and-…
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jobrxiv.org/job/brigham-and-…
Marie Hollenhorst, MD, PhD retweeted
A lack of funding and incentives for research into antimicrobial resistance is causing scientists to leave the field go.nature.com/3UL5jq4