We're winding down our Twitter account and moving to BlueSky Find us at @houseleylab.bsky.social We'll still post a few announcements here though...

Great work lead by Hanane Hadj-Moussa and Megan Ulusan Babraham Institute @BabrahamInst @BBSRC @UKRI_News

AMPK orchestrates responses to low nutrient availability from yeast to humans… …including regulation of fatty acid synthesis through phosphorylation of the same enzyme This conserved regulatory system presents an unexplored target for healthy ageing research across Eukaryotes

Controlling Acetyl coenzyme A underlies all these effects Acetyl coenzyme A is the building block for fatty acids but excess acetyl coenzyme A availability is detrimental A2A cells make the fatty acid they need but get rid of excess acetyl coenzyme A into mitochondria

But AMPK activation turns off fatty acid production, which is a problem Our A2A mutant combines AMPK activation with a mutation that allows continued fatty acid synthesis The majority of A2A cells maintain fitness very late in life even though they don't live any longer

AMPK activity is widely considered to be beneficial for ageing health We show that AMPK activation in budding yeast allows some cells to age without senescence on a normal diet

Is healthy ageing possible on a normal diet? Our latest Preprint describes metabolic re-engineering of yeast to avoid senescence The A2A mutant we created is super-fit late in life even on a rich high glucose diet biorxiv.org/content/10.1101/…

Congratulations to Hanane for her interview 🎉🎉

Congratulations Hanane!

Congratulations to our PhD students @PaolaGarran, Kieron and @baptiste_piguet for presenting their posters! 🧵(2/6)

At @BabrahamInst, we recently held our annual Lab Talks, during which awesome science was discussed. In this #Thread, we are highlighting the accomplishments of our members this year🏆 🧵(1/6)👇

Join us at this year's BSRA meeting to discuss all things ageing! We have some great speakers from academia and industry Abstract deadline extended to June 14th bsra.org.uk/events/bsra-annu…

Great work from @GabrielePicco2 @Garnettlab showing how WRN inhibitors can selectively target MSI cancer cells

Looking forward to your comments 👩‍🔬 #ResearchMilestones #GeneticHeterogeneity #Transcription #PhDachievement (6/6)

Finally, we propose that TRCs induce mutagenesis usually when replication is already perturbed, particularly during Break-Induced Replication, which would explain the role of transcription in gene copy number variation and the formation of extrachromosomal DNA circles. 🧵(5/6)👇