MD-PhD Student @nyugrossman via @danafarber & @fulbrightnl. Cancer Genomics in the Petljak Lab @Perlmutter_CC. he/him
Boston, MA
Joined May 2019
- Tweets275
- Following382
- Followers614
- Likes4.7K
Jacob Rozowsky retweeted
Our lab’s first APOBEC3 paper, with the @maciejowskilab 🎊, is out - dissecting contributions of A3 paralogs to mutagenesis in lung cancer cells! Endogenous A3A drove the census signature InD9a. As A3s emerge as drug targets, our data also reinforce our past call for caution about inferring mutagenic output from expression or lysate activity alone
Link: doi.org/10.1016/j.celrep.202…
Jacob Rozowsky retweeted
We are all mosaics with our cells accumulating somatic mutations as we age. Now that is getting fully comprehensively quantified @CellCellPress
cell.com/cell/fulltext/S0092…
Jacob Rozowsky retweeted
I’m hiring a Senior Bioinformatician at NYU Grossman School of Medicine! 🧬
Lead computational research in my lab to uncover what drives cancer mutations & tumor evolution.
📍 NYC | Visa sponsorship available
Apply: jobs.nyulangone.org/job/2390…
Please repost!
Jacob Rozowsky retweeted
DNA can remember many cancer-causing environmental exposures long after they end.
Could reading those records in at-risk populations strengthen conventional epidemiology, uncover overlooked causes of cancer—and help prevent it?
We explored the promise—and missing pieces—of mutational epidemiology in our Trends in Cancer Opinion earlier this year. Link👇
sciencedirect.com/science/ar…
Jacob Rozowsky retweeted
Colorectal cancer rates are falling in adults over 60, but among adults under 45, the disease is rising.
Mia Petljak, PhD, is studying tumor DNA for mutational signatures linked to plastic exposure to better understand whether microplastics may be contributing to the trend. ⤵️
Jacob Rozowsky retweeted
I’m incredibly grateful to @psscra for the Pershing Square Sohn Cancer Prize, recognizing our work and enabling an important part of our broader vision to develop personalized cancer prevention strategies 🙏
Jacob Rozowsky retweeted
Congratulations to Mia Petljak (@DRMP2025) @Perlmutter_CC on being awarded a @psscra Cancer Prize!
Mia’s proposal focuses on the mutational signatures of microplastics in cancer, including early onset cancers. And she made the announcement cover!
pershingsquarephilanthropies…
Jacob Rozowsky retweeted
🚨🚨🚨
RASOLUTE-302 Ph3 is POSITIVE
"Daraxonrasib demonstrated a median OS of 13.2 months versus 6.7 months for chemotherapy, with a hazard ratio of 0.40 (p < 0.0001)".... WOW!
AMAZING news for patients with #PancreaticCancer
The RAS Revolution is ON!!
ir.revmed.com/news-releases/…
Jacob Rozowsky retweeted
Proud and excited to welcome the residency class of 2031 to the @HopkinsOrtho family! The future of ortho is super bright! @Str8bonesJim @BabarShafiqMD @orthomentor1
Jacob Rozowsky retweeted
‼️Next up: We introduce our newest class of @UCSFPlastic Surgery residents. Four future surgeons who've matched into one of the most competitive training paths in #medicine. Join us in welcoming the newest members of our Plastic #Surgery family✂️ #Match2026
Jacob Rozowsky retweeted
Excited to work with the new talent joining the #Neurorusgrery Department @MayoClinic @MayoNsgyRes @MayoClinicNeuro @MayoClinicSOM
#MatchDay2026: We are elated to welcome our newest Neurologic Surgery residents to @MayoClinic in Rochester, Minnesota! 🌟 Our future is certainly bright.
Jacob Rozowsky retweeted
Nature research paper: Multidimensional profiling of heterogeneity in supratentorial ependymomas
go.nature.com/4brosUV
Jacob Rozowsky retweeted
Thrilled to share our latest study on pediatric ependymoma, out in @Nature! Biggest congratulations to all members of our international team, especially the labs of @VarunVenkatara2 and Kristian Pajtler, and fearless leader in my lab, @DaeunJeong10. @DanaFarber @BostonChildrens
Delighted that this work uncovering developmental links to supratentorial ependymoma is out now in @Nature! Again huge thanks to our collaborators @VarunVenkatara2 and pajtlerlab, and all of our many friends who helped push this to the finish line! nature.com/articles/s41586-0…
Jacob Rozowsky retweeted
Where do cancers start? In the liver, not all cells are the same. The liver is divided into 3 “zones,” and each specializes in different metabolic tasks. We show in @Science that where a mutation occurs in a liver lobule can determine a cell’s fate. science.org/doi/10.1126/scie… (1/9)
Jacob Rozowsky retweeted
Big, beautiful trees!!
SMART-PTA for whole-genome+transcriptome on thousand of single cells from the normal human esophagus 🤯 Massively scaling up the power of scWGS to build deep phylogenies and chart somatic evolution from birth throughout life.
biorxiv.org/content/10.1101/…
Jacob Rozowsky retweeted
Congratulations & remembering Karenna Groff
Thank you @wenyalindabi for the co-submission of the work on #TERT in #meningioma
@TheLancetOncol
Adding more to the strength of the work from @ICOMeningioma
#cIMPACT @WHO
@NeuroOnc
Grateful to the many teams who supported this work, championed by Karenna Groff. As we uncover more biomarkers of tumor behavior, implementation into clinical practice merits close introspection of context. @MGBneurosurgery @LabRaleigh @sahm_lab @MGBCTNS @NYUneurosurgery @RuchitVP
Jacob Rozowsky retweeted
Grateful to the many teams who supported this work, championed by Karenna Groff. As we uncover more biomarkers of tumor behavior, implementation into clinical practice merits close introspection of context. @MGBneurosurgery @LabRaleigh @sahm_lab @MGBCTNS @NYUneurosurgery @RuchitVP
Proud to share our collaborative work, now published in @TheLancetOncol. This project stands as a testament to the talent and enduring spirit of Karenna Groff. Thanks to @wenyalindabi for her dedication in bringing this to publication. @MeningiomaBot authors.elsevier.com/c/1liJQ…
Jacob Rozowsky retweeted
Big moment for the lab—officially welcoming Fiona — our first PhD student! ⭐️🎉
Mentorship is one of the most rewarding parts of this job, and I can’t wait for us to embark on the first of many PhD journeys ahead 🤗
Jacob Rozowsky retweeted
Thrilled to share our work @FilbinMariella, @GojoJohannes, and @CarlKoschmann, now published in @Cancer_Cell. We present a translational approach identifying the PDGFRA inhibitor avapritinib as a novel targeted treatment for pHGG with PDGFRA alterations. cell.com/cancer-cell/fulltex…
Jacob Rozowsky retweeted
1/ This is the next chapter of a story about courageous patients and their families, of multidisciplinary teamwork, and hard-fought steps forward to effective therapy for #DIPG #DMG, a universally lethal cancer of the brain and spinal cord. 🧵nature.com/articles/s41586-0…
