Heart Failure Cardiologist & Investigator, @BrighamWomens @harvardmed @broadinstitute AI to Improve Cardiovascular Clinical Trials & Care
Boston, MA
Joined February 2018
- Tweets433
- Following523
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Jon Cunningham retweeted
The brilliant ⭐️David Morrow delivering @MassGenBrigham HVI Grand Rounds on history and evolving role of CICU, training pathways, research challenges, and opportunities for improving care.
High intensity staffing model --> better outcomes!
Jon Cunningham retweeted
An editorial by @HashemZikry @latimes @counselheatlh calling for more regulation of AI for patient use.
Yes, there is "the staggering weight of unmet medical need," 1/3 Americans are using it to "diagnose symptoms and direct care," and states are moving in different directions.
But the core problem now is lack of compelling proof of efficacy and safety, not the FDA.
latimes.com/opinion/story/20…
Jon Cunningham retweeted
Congratulations to Dr. Jennifer Ho on her promotion to Professor of Medicine @harvardmed! As Director of Research in our Division of Cardiovascular Medicine, she has been instrumental in empowering collaborative research to advance cardiovascular health 🌟
bit.ly/4sZJGjj
Jon Cunningham retweeted
🚨New in @JACCJournals
Can #CCTA stratify heart failure risk through radiomic phenotyping of epicardial adiposity?
We derived & externally validated a deep radiomic signature of epicardial fat in >70,000 adults.
w/ @Charis_Oxford on behalf of the #ORFAN consortium
🧵👇
Jon Cunningham retweeted
Not All Hospitalized Heart Failure Patients Are the Same: A New Worldview
jacc.org/doi/10.1016/j.jchf.… @JACCJournals
Jon Cunningham retweeted
@CVCTForum is the best scientific meeting I have attended 🙌🏻 thanks @ZannadFaiez for the invitation!
Great to catch up with @scottdsolomon & entourage
Team #STRONG@HOME was well represented 😁- and the trial was highly relevant as digital care/ AI in CRM was the main topic
Jon Cunningham retweeted
Celebrating Women in Cardiology at AHA 2025 ❤️
An inspiring afternoon at @AHAScience #WIC Luncheon, where leaders, mentors, and future changemakers came together to celebrate excellence and equity in our field.
Jon Cunningham retweeted
📢 Time for one of our most anticipated meetings of the year!
Novel Statistical Concepts for HF Drug and Device Development
Join us on November 14, 2025 | 8:45 a.m - 12:30 p.m. ET via Zoom
Open to all — no HFC membership required
Register here:
hfcollaboratory.com/meetings…
Jon Cunningham retweeted
🚨 New in @CircAHA : Maternal CVD and pregnancy-related CV complications are rising sharply over 2 decades across >56K pregnancies across @MassGenBrigham.
Pregnancy is a critical window for lifelong heart health!
🔗doi.org/10.1161/CIRCULATIONA…
@MGBResearchNews #CardioObstetrics
Jon Cunningham retweeted
📢Personal update!
✨Thrilled to share that I’ll be moving my clinical practice to @BrighamWomens as Director of Women’s Heart Health.
So grateful to my many mentors, colleagues & friends 🙏. Excited for this next chapter working to advance women’s 🫀 health!
@MGBWomenHeart
Jon Cunningham retweeted
Flu causes major illness and death, but vaccination rates are falling. A large trial found that cardiovascular-focused nudges did not increase vaccination rates. In an accompanying editorial, the authors contextualize the findings. eviden.cc/3JFgTiW
![“[KP-VACCINATE] is an excellent example of a pragmatic, population-wide nudge trial delivered through existing and widely available EHR technologies.” EDITORIAL Kaustav P. Shah, MD, and Srinath Adusumalli, MD, MSHP, MBMI](https://pbs.twimg.com/media/G2GbQeVaQAANoA9.png?name=orig)
ALT “[KP-VACCINATE] is an excellent example of a pragmatic, population-wide nudge trial delivered through existing and widely available EHR technologies.” EDITORIAL Kaustav P. Shah, MD, and Srinath Adusumalli, MD, MSHP, MBMI
Jon Cunningham retweeted
🚨 An extraordinary achievement from all the @CTCPR_ researchers at ESC! Our researchers simultaneously published 13 papers across leading journals, showcasing some of the latest breakthroughs in cardiology.
These publications include:
· 3 in The New England Journal of Medicine
· 1 in The Lancet
· 1 in JAMA
· 2 in European Heart Journal
· 3 in Journal of the American College of Cardiology
· 1 in JAMA Cardiology
· 1 in JAMA Open
· 1 in Circulation: Heart Failure
This remarkable achievement reflects the dedication and collaboration of the @CTCPR_ team. Each study contributes valuable insights that hopefully will help improve patient care and inform clinical practice worldwide.
👏 Huge congratulations to all @CTCPR_ researchers and collaborators for their hard work, perseverance, and commitment to advancing science.
@NEJM @thelancet @JAMANetwork @ESC_Journals @JACCJournals @JAMACardio @JAMANetworkOpen @CircHF
Jon Cunningham retweeted
How can AI enhance Clinical Trials?
In latest @hfcollaboratory Heart of the Matter Podcast
@coconnormd & panel share ideas on how to use AI to increase value/quality, design, patient selection, other aspects
@mpsotka @dranulala @ankeetbhatt
youtube.com/watch?v=r_urcTR_…
Jon Cunningham retweeted
Delighted to have shared the results of ENVAD-HF as late-breaking science at #ESCCongress: 1st prospective RCT of #HeartFailure #GDMT #sacval in #LVADs:
-numerically less primary outcome (death, ⬇️ renal fn, hypotn and hyperK)
-safe, feasible, well tolerated
-improved PROs
ENVAD-HF, a prospective RCT in stable HM3 #LVAD recipients, shows angiotensin–neprilysin inhibition is safe and well-tolerated, paving the way for trials of #HF therapies in this population. jacc.org/doi/10.1016/j.jchf.…
#JACCHF #ESCCongress #WCCardio @MajaCikes @scottdsolomon
Jon Cunningham retweeted
In a large individually randomized trial embedded in routine care across a national U.S. health system, a cardiovascular-focused nudge intervention did not increase influenza vaccination rates on a background of low-uptake. Full trial results: eviden.cc/4mo2PZP #ESCCongress
ALT Figure 2. Primary Outcomes of KP-VACCINATE.
Jon Cunningham retweeted
The countdown is on! DANFLU-2 will be presented at #ESCCongress on Saturday!
332,438 adults ≥65 years 👵👴
High-dose vs standard-dose influenza vaccine 💉
Severe outcomes: hospitalizations and deaths 🏥☠️
Design paper: bit.ly/47P65ZE
Look out for simpubs! 👀
Jon Cunningham retweeted
Very pleased to share our review on AI echocardiography in cardiovascular disease management is now published!
I hope this article serves as a resource for continued learning, discussion, and collaboration across the field.
🔗nature.com/articles/s41569-0…
Jon Cunningham retweeted
🧵1/Today, we published a key milestone towards AI based cardiac screening in Nature. doi.org/10.1038/s41586-025-0…
EchoNext outperformed cardiologists and found thousands of high-risk patients missed in routine care. We also made a version available to the world.
Jon Cunningham retweeted
Rationale, Design, and Baseline char. of KP-VACCINATE out in @AmericanHeartJ. ~3.8 Million adults randomized in 2 integrated learning healthcare systems in ~4 weeks. To our knowledge, the 🌟largest RCT ever🌟 & fully embedded in routine case. Results soon sciencedirect.com/science/ar…
Jon Cunningham retweeted
Excited that #PanEcho is now published in @JAMA_current
Kudos to @giholste @ekoikonomou for leading this incredible effort!
Now also validated on ED POCUS studies + RVNet+ (Thx Attila Kovacs & Marton Tokodi for joining us)
See 🧵 below for details!
jamanetwork.com/journals/jam…
#OpenSource #AI
After 2 months of embargo for #AHA24 Late Breaking presentation, we are pleased to announce PanEcho - Complete AI-enabled echocardiography interpretation with multi-task deep learning
Led by @giholste & @ekoikonomou @cards_lab
Preprint, code, model here: cards-lab.org/panecho