Senior bioinformatic scientist at St. Jude Children's Research Hospital
Memphis
Joined January 2011
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Many pediatric cancers are fundamentally developmental disorders. With our recent publication we have discovered the origins of medulloblastoma within the developing cerebellum. #teamscience #stjude
nature.com/articles/s41586-0…
Kyle S Smith retweeted
The Northcott lab conducted an extensive re-analysis of a single-cell transcriptional atlas of human cerebellar development originally published in 2022. During this process, we identified significant concerns related to data integrity and interpretation,
Kyle S Smith retweeted
Where does medulloblastoma come from? St. Jude scientists have helped figure it out. bit.ly/3xIYo4i
@drpaulnorthcott @nature #childhoodcancer #braintumor #CCAM #CancerResearch
These cells are located in a region of the cerebellum known as the Rhombic Lip, which give rise to the glutamatergic neurons. Overlapping MRIs of many Group 3 and 4 medulloblastoma tumors revealed that these tumors are fully encapsulated within this region.
These findings set the foundation to better model and hopefully treat these tumors going forward. So proud to be a part of this all-star team with Laure Bihannic and @B_gudenas headed by @drpaulnorthcott and @neurodevKathy
Kyle S Smith retweeted
St. Jude scientists have discovered the developmental origins for Group 3 and Group 4 medulloblastoma which may help improve research models and potential therapeutics. bit.ly/3S2eT3J @nature @drpaulnorthcott #childhoodcancer #CCAM
Kyle S Smith retweeted
1/5 Our new paper resolving the developmental origins of Group-3 Medulloblastoma is out @Nature
Previously the cellular origins of Group3-MB were unknown despite multiple cross-species efforts comparing MB tumors to mouse cerebellar single-cell atlases.
nature.com/articles/s41586-0…
Kyle S Smith retweeted
UPDATE: the suspect is still at large. If you do not have to be out, stay indoors until this is resolved.
Kyle S Smith retweeted
As we bid a final goodbye today we ll fondly remember Prof. Zoltan Patay for his immeasurable contributions to #pedineurorad
@drmankad
@StJudeResearch @The_ASPNR @ESNRad @zguroztekin @drpaulnorthcott @TYPoussaintMD @draash @hakimaalhashimi @LorenzoPinelli @nihaal08 @MirskyDavid
Kyle S Smith retweeted
Excited to share our latest pre-print building a single-nucleus atlas of pediatric rhabdomyosarcoma. We report heterogeneity within 18 patient tumors, and 18 xenografts from those same patient tissues, and show treatment selects for mesoderm-like cells #sarcoma @StJudeResearch
ascopubs.org/doi/abs/10.1200…
Excited to have this one out, and to be part of the great clinical work being done at St. Jude.
Its going to be a crazy night! Rocking some scrabble, maybe a movie, bed by 11 @erikdauster #gangster
@jasonemillar Do we have class tuesday? I think he said we do but his website says no #jins333