Postdoc in Yardena Samuels’s lab. Weizmann Institute. Metastatic Microenvironment Researcher
Joined November 2019
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- Following123
- Followers106
- Likes259
Lea Monteran retweeted
Proud to share @niseto’s (new PI @TheCrick) paper:
As a postdoc (@CSHL/@HopkinsMedicine), he found #NETs in necrotic tumors—I shrugged. But he looked closer: NETs block tumor vessel perfusion, causing necrosis, hypoxia, EMT & #Metastasis.
nature.com/articles/s41586-0…
@JHU_BDP @Nature
Lea Monteran retweeted
Thrilled to share our work in Cancer Cell! Huge thanks to my PI and mentor @samuels_yardena ,OsnatBartok, and our collaborators @chrismcginnis,@Satpathology , Andreas Schlosser,@EytanRuppin & more. We reveal how impaired translation fidelity enhances anti-tumor immunity!🧵(1/8)
Lea Monteran retweeted
Thank you @EACRnews for highlighting our work on breast cancer bone metastasis!
New immunotherapy combinations are the way to combat #metastasis.
@LMonteran @CD_AACR
magazine.eacr.org/highlights…
Lea Monteran retweeted
WOW!!! We are so excited for this!
Congratulations @ErezNeta - no one is more deserving!
The @IscrFor is grateful to the outgoing president @cohen_cyrille for leading the society in the past 4 years 🌷👏🏼
We welcome the new President @ErezNeta and Vice President @ShakedYuval and look forward to their leadership!
Stay tuned for information on the 2025 Annual Meeting!
Lea Monteran retweeted
סרטון סגל הנבחרת לאולימפיאדה הוא הסיפור של כולנו כאן, החיים בין הכאב לתקווה.
בין דמעה של צער גדול לדמעה של אושר.
הוא גם המחווה שלנו למדינה האהובה של כולנו.🇮🇱
#westandready
Lea Monteran retweeted
From David Lyden @WeillCornell & Tran in @NatureMedicine
Multi-parametric atlas of the pre-metastatic liver for prediction of metastatic outcome in early-stage #PancreaticCancer
nature.com/articles/s41591-0…
A challenging study design to pull off, wherein uninvolved liver is sampled during surgical resection of localized pancreatic cancer in order to profile the pre-metastatic niche and identify patterns that predict early v late liver metastases, extrahepatic recurrence or absence of recurrence.
Neutrophil extracellular traps (NETs) are a pivotal predictor for early liver recurrence. More evidence supporting the role of NETs in creating a seedbed for metastatic dissemination.
Lea Monteran retweeted
In Science, researchers report the characterization of a previously unidentified route by which breast cancer cells metastasize to the leptomeninges in mice. The findings could inform future therapies.
📄: scim.ag/7sW
#SciencePerspective: scim.ag/7sX
Lea Monteran retweeted
An unexpected corridor to the brain- Amazing paper in @ScienceMagazine reports a surprising route by which cancer cells metastasize from bone to the leptomeninges.
science.org/doi/10.1126/scie…
We wrote a perspective on these important findings:
@LMonteran
science.org/doi/10.1126/scie…
Lea Monteran retweeted
How can we treat bone #metastasis? @LMonteran gave an excellent talk sharing our recent findings. Bravo Lea!! You make me proud #proudPI #MRS2024
Lea Monteran retweeted
My latest research highlight focuses on a recent paper from @ErezNeta group, identifying key interactions between granulocytes & T cells that promote an immunosuppressive bone microenvironment permissive to metastasis.
Lea Monteran retweeted
Thank you @NatureRevCancer @gabe__brewer for highlighting our study published in @CD_AACR on bone metastasis!
We LOVE the title: "Bone Voyage: immune crosstalk sets sail".
nature.com/articles/s41568-0…
My latest research highlight focuses on a recent paper from @ErezNeta group, identifying key interactions between granulocytes & T cells that promote an immunosuppressive bone microenvironment permissive to metastasis.
Lea Monteran retweeted
#ScienceSaturday
When cancers spread to bone they can be especially difficult to treat. In this study, investigators found that myeloid-derived suppressor cells (MDSC) inhibit T cells in the bone microenvironment and that inhibition of the cytokine IL1beta and the immunosuppressive receptor TIGIT could reverse this immunosuppression in a #breastcancer mouse model. This study may inform future trials for patients with bone metastases.
@LMonteran @NourErshaid @ErezNeta @TelAvivUni
Here's a full link to the article: aacrjournals.org/cancerdisco…
Lea Monteran retweeted
#ICYMI: Combining TIGIT Blockage with MDSC Inhibition Hinders #BreastCancer Bone #Metastasis by Activating Anti-tumor Immunity, by @LMonteran, @ErezNeta et al.
bit.ly/48MCtcp
@TelAvivUni
Lea Monteran retweeted
🤩And now with the art opener illustrating the findings in this beautiful @CD_AACR paper by @ErezNeta, @LMonteran and colleagues 👇👏 aacrjournals.org/cancerdisco…
Now online in @CD_AACR: Combining #TIGIT Blockage with MDSC Inhibition Hinders #BreastCancer Bone Metastasis by Activating Anti-tumor Immunity @LMonteran @ErezNeta doi.org/10.1158/2159-8290.CD… @TelAvivUni
Lea Monteran retweeted
TIGIT blockade with MDSC inhibition may be a novel and promising therapeutic strategy to treat bone metastasis - @LMonteran
@ErezNeta @CD_AACR
oncodaily.com/38920.html
#BoneMetastases #Cancer #BreastCancer #OncoDaily #Oncology
Lea Monteran retweeted
#OnlineFirst: Combining TIGIT Blockage with MDSC Inhibition Hinders #BreastCancer Bone #Metastasis by Activating Anti-tumor Immunity, by @LMonteran, @ErezNeta et al.
bit.ly/48HvIIO
@TelAvivUni
I am excited to share our latest work (and PhD’s baby) @ErezNeta on breast cancer bone #metastasis, showing how combining #TIGIT blockade with #MDSC inhibition may be a novel and promising therapeutic strategy to treat bone metastasis. In @CD_AACR 😊
doi.org/10.1158/2159-8290.CD…
I obviously thank all my colleagues that helped me through this adventure, especially @NourErshaid & @YeelaScharff ! ♥️ 🩷🧡💛💚🩶💙
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Moreover, we show that TIGIT is expressed in human bone metastasis from multiple cancer types.
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We are grateful to our amazing collaborators that participated in this great project @XiangHFZhang1 from @lab_bcm , Iris Barshack from @sheba_medical and @nshomron.
I thank my incredible and inspiring mentor @ErezNeta for guiding and supporting me and my research ♥️.
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