@LabMelnick

Investigating epigenetic and transcriptional dysregulation in hematological malignancies 🧬

 Manhattan, NY
melnicklab.org/
Joined May 2019
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  • Following184
  • Followers895
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Check out this incredible new story led by Darko Barisic @edeon from the lab on chromatin remodeling GC B cells and B cell lymphoma!!🔥
Darko Barisic@LabBarisic7 Mar 2024
Very excited to share our new paper on how mutations in SWI/SNF chromatin remodeling complexes alter chromatin dynamics and immune cell-fate to drive lymphoma, online now in @Cancer_Cell. authors.elsevier.com/c/1ijJ0… More details in the thread below.👇 🧵 1/n
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Thrilled to share we are @theNCI R00-funded. 🥳 Looking for computational biologists or bioinformaticians. 👩‍💻👨‍💻 We have many exciting projects on the role of chromatin remodelers in blood cancers. 🩸🦀 Please share/DM/email if relevant. Our latest story: cell.com/cancer-cell/abstrac…
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We are on the cover of Cancer Cell! Check out our latest story on ARID1A and BAF remodeling complex in lymphoma: doi.org/10.1016/j.ccell.2024… Led by @edeon @ChrisRChin. @WCMLymphoma @WCM_MeyerCancer @WeillCornell @Cancer_Cell
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Researchers identify mechanisms that can transform follicular lymphoma into an aggressive form of cancer in some patients. Findings from a team led by Dr. Ari Melnick (@LabMelnick) of @WCM_MeyerCancer suggest potential for new therapeutic strategies. bit.ly/3TsJucs
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Melnick Lab retweeted
Cancer Cell@Cancer_Cell8 Mar 2024
Online Now: ARID1A orchestrates SWI/SNF-mediated sequential binding of transcription factors with ARID1A loss driving pre-memory B cell fate and lymphomagenesis dlvr.it/T3p5fw
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Melnick Lab retweeted
Quinn@QuinlanSievers8 Mar 2024
I learned so much from reading the excellent papers by the Melnick and Green labs and even more when we attempted to distill their observations into a succinct preview article. Check out their work on how BAF complex mutations contribute to lymphomagenesis!
Taylor Lab UM@TaylorJ_MD7 Mar 2024
Replying to @GreenLymphoLab @MDAndersonNews @LabMelnick @Cancer_Cell
Congratulations Michael! And Ari! Nice editorial by @QuinlanSievers and @AbdelWahablab SWI/SNF regulation of germinal center fate and lymphomagenesis sciencedirect.com/science/ar…
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and co-published story by @GreenLymphoLab -- great time for epigenetics in the B cell lymphoma field!
Michael Green, PhD@GreenLymphoLab7 Mar 2024
How do BAF (SWI/SNF) mutations drive lymphoma? Back-to-back papers from our group @MDAndersonNews and @LabMelnick lab on SMARCA4 and ARID1A mutations online in @Cancer_Cell today. A brief summary... sciencedirect.com/science/ar…
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Happy Holidays!
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And please stop by our posters on Sunday and Monday #ASH2023 to learn about more amazing work on DLBCL models and biology! including cool new data by @LScourzic with @efapostolou29 lab
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Come check out the exciting new work by Yusuke on EZH2 inhibition and CART activity against lymphoma! #ASH2023
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Interested in learning what chromatin remodelers do in immunity and lymphoma? Dont miss a talk by Darko @edeon from our lab at #ASH2023. @ASH_hematology Monday, Dec 11 — 11:15 AM — Marriott Marquis San Diego Marina, Pacific Ballroom Salons 15-17
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Check out this remarkable paper from the Julie Leca in the Tak Mak lab! We are honored to have participated in this project. They have some amazing findings regarding interplay between malignant TFH cells and the immune microenvironment! cell.com/cancer-cell/fulltex…
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During antibody affinity maturation in germinal centers (GCs), many defective B cells die by apoptosis. These cells are removed by tingible body macrophages (TBMs). Here, we describe their origin and function. 🧵@NGurwicz doi.org/10.1084/jem.20222173 @JExpMed
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Read this week's Cancer Discovery #ResearchWatch: Mutations in BTG1 Promote Germinal Center #Bcell Malignant Transformation, a summary of the paper by @coraline_mly, @LabMelnick et al. bit.ly/3XKybgL @WeillCornell
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The reason I find academia so hard, is I am wired for a kind of love that this place cannot sustain. I think of ways to cite colleagues, to lift them up, to support them. All the time. It is not reciprocal with so many others. I find it painful. I'm not sure how long I can last.
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Billions of Google searches and billions of YouTube streaming hours each day translate into billions of litres of water needed for cooling Google’s data centres newscientist.com/article/235…

Google has finally revealed how much water its data centres use | New Scientist

Google had previously kept its data centre water usage secret but it has recently revealed how many billions of litres it uses each year

newscientist.com
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Raise your hand all who enjoy spending all 48 hours of the weekend writing grants!
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Amazing lecture at Weill Cornell from Vijay Sankaran @bloodgenes!! Elegant and brilliant - thanks for visiting us!
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Here is our tweetorial on this crazy story, led by @coraline_mly from my lab. science.org/doi/10.1126/scie…

BTG1 mutation yields supercompetitive B cells primed for malignant transformation

Lymphoma BTG1 mutations reveal a tumorigenesis mechanism that recapitulates developmental super-competition processes.

science.org
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Heartfelt thanks to @victora_lab, @KharasLab, @ElementoLab and Drs. Meyer-Herman, Khelashvili, Scott, Jaffrey, Chen and Chadburn for helping to crack this amazing puzzle! Thanks to @ceydadurmaz569 for the great cartoon (see 4/20)
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Thanks to support from @lymphoma @LLSResearch @ASH_hematology @theNCI @WCMlymphoma @WCM_MeyerCancer and The Starr Foundation and #ScienceResearch. #immunology #Bcells #lymphoma #germinalcenter . .
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