We are located in @TelAvivUni. We study the neuronal and molecular basis for severe epilepsy and autism.
Israel
Joined October 2018
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Excited to share our paper! #GRIN2D-DEE 🐭model mirrors patient symptoms, from behavioral deficits and pathological brain activity to synaptic changes🔗 shorturl.at/JL6pyA
An incredible collaboration with a GRIN2D family, @KarenAvraham, researchers & clinicians.
Happy to share our new collaborative paper exploring the molecular basis of DEE-related #SCN8A mutation 🍾 | Work led by @QuinnShir with Yuanyuan Liu, @roybensh, @HaitinLab 🥰, Haim Bassan #epilepsy surl.li/rvzbw
When injected at P21, following the onset of seizures in Dravet mice, CAV2-SCN1A corrected hippocampal inhibition.
CAV-2 vectors driving the expression of Nav1.1 under the control of the NSE promoter led to expression in excitatory and inhibitory neurons at the injection site, and with CAV-2's retrograde transport properties, in additional brain regions that project to the injection site.
📢 A novel gene therapy for #Dravet. jci.org/articles/view/159316…. Using Canine adenovirus-2 (CAV-2) we delivered the full SCN1A coding sequence into the hippocampus and thalamus of juvenile Dravet mice.
Thank you @banet_g and Eden for an amazing dinner! Wonderful food and atmosphere❤️🥰🙏🏼
New preprint alert!🎊 Examining the acute effect of anti-seizure 💊 on background EEG in #Dravet 🐭, we show that ⬇️ reduced and redistributed power (theta/beta ratio) correlates with ⬇️ freq. of interictal spikes. #biomarker? biorxiv.org/content/10.1101/…
Yael did an excellent work highlighting the divergent response of excitatory and inhibitory neurons to the Hm1a. These data indicate the neuronal mechanism of Dravet is
We were very happy to have @Gregory_Truman over the last two months for his summer research program. Thanks you and best of luck with your studies🎉 – at Israel
