We are located in @TelAvivUni. We study the neuronal and molecular basis for severe epilepsy and autism.
Israel
Joined October 2018
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📢 A novel gene therapy for #Dravet. jci.org/articles/view/159316…. Using Canine adenovirus-2 (CAV-2) we delivered the full SCN1A coding sequence into the hippocampus and thalamus of juvenile Dravet mice.
In collaboration with Else Tolner (LUMC) and Eric Kremer (CNRS), and the amazing teamwork of Georgii Krivoshein, Hala Majadly, @Anat_Mavashov, Shahak Ranen, Marina Brusel, @iriareyes, and Bernard Boucher 🤩
This work is dedicated to the memory of Dr. @SajaFadila1, my first student, who led this research 💔
Sleep and thermoregulation are usually coupled. In our new paper, we find that in a #Dravet syndrome 🐭 this coupling collapses, with sleep failing to induce cooling and warmth failing to promote sleep.
nature.com/articles/s41467-0…
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Congratulation!! 🥳🥳🎈🎈
🚨It's finally out!🥂 | A few years after solving the structure of human cis-PT, we now tackle its dynamics in @NatureComms, revealing that a conserved interfacial loop serves as an allosteric hub, communicating with the active site to regulate catalysis. rdcu.be/eShjl
RubinsteinLab retweeted
🚨It's finally out!🥂 | A few years after solving the structure of human cis-PT, we now tackle its dynamics in @NatureComms, revealing that a conserved interfacial loop serves as an allosteric hub, communicating with the active site to regulate catalysis. rdcu.be/eShjl
RubinsteinLab retweeted
Excited to share our new paper in @FEBSJournal! 🎉
We show how a #MYELOMA-linked GGPPS mutation tweaks hexamerization, substrate binding and product inhibition, revealing an unexpected layer of protein prenylation regulation
🔗 doi.org/10.1111/febs.70181
@peterslab1 @TAUMedFaculty
🚨New preprint alert! Wonder how a cancer-associated mutation in GGPPS impacts hexameric stoichiometry, substrate affinity, and product inhibition? Our results shed light on a novel regulatory mechanism in protein prenylation bit.ly/3ZR7w47 #MultipleMyeloma
Congratulations!! 🥳🥳
How does a cytoplasmic enzyme make a membrane product? 🤔🧬
We found that a hydrophobic residue cluster helps the human cis-prenyltransferase feed its product into the ER membrane!
MD simulations + fluorescence = mechanistic insight 👇
🔗doi.org/10.1002/pro.70167
RubinsteinLab retweeted
Stop the doom scrolling! A new 🗞️ from my lab, describing one of our flagship projects of many years we are super excited to share:
"Inducible formation of fusion transcripts upregulates haploinsufficient CHD2 gene expression".
A 🧵biorxiv.org/content/early/20…
An outstanding group of devoted students - Mor Yam, Jolan Nassir, Danielle Galber, Shir Quinn, Roni Gal, Eden Peled, Mor Ovadia, Mor Bordeynik Cohen; Wayne Frankel, Christopher Makinson, Moran Hausman-Kedem, Aviva Fattal-Valevski. @TAUMedFaculty
Excited to share our paper! #GRIN2D-DEE 🐭model mirrors patient symptoms, from behavioral deficits and pathological brain activity to synaptic changes🔗 shorturl.at/JL6pyA
An incredible collaboration with a GRIN2D family, @KarenAvraham, researchers & clinicians.
