MD PhD🇳🇱|👩⚕️Cardiology| 👩🏫 Postdoc Fellow in Translational Cardiology focusing on Sex differences in Heart Failure, HFpEF + Cardio-Obesity. Glutenfree.
Groningen, the Netherlands
Joined January 2009
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This morning during a combined #AHA #ACC and #ESC session at #ESC2024 I advocated for a new subspecialty of “cardiobesity”. What do you think? Yes ✅ or no 🛑?! @HanCardiomd @escardio @matthewmylee
❗️At #ESCCongress now: “We may have to conclude BMI is outdated; we need other factors” says @laurameems. She suggests new subspecialty: “cardiobesity” #obesity #CardioTwitter
Today I gave a talk at #ESC2024 about #glp1ra in #HFpEF. A fully packed room and 12 minutes to talk about new insights.
What you missed?
✅ obesity is important, also for cardiologists
✅ glp1RAs are cardioprotective
✅ MoA studies are needed
@escardio @HFA_President
#hartfalen in de spotlight tijdens #nationalehartfalenweek!
In een interview met @hartinshape en @vrouwenhartspreekt sprak ik over hartfalen, man-vrouw verschillen én onze #hfpef poli in @umcg @CardiologyUmcg @WestenbrinkDaan
Benieuwd naar meer?
hartinshape.nl/blog/onzichtb… – at Groningen, Nederland
Ben jij…
✅ een (bijna) arts met ambitie onzichtbaar hartfalen gemakkelijker op te sporen
✅ geïnteresseerd in de nieuwste MRI technieken en cardiologie
✅ een zelfstandige teamspeler die niet bang is om te innoveren
Solliciteer dan nu! #phdstudent
werkenbijumcg.nl/-/vacatures… – at Groningen, Nederland
Laura Meems retweeted
#PCHF Zürich continues to set standards and lead #HeartFailure education in Europe, with a global reach. Congratulations to all of the graduates, faculty and leadership of the course - 5 generations raised, more to come! Honored to be part of this stellar family! 🎓💥🫀📚
Thank you prof. Marc Pfeffer for your words of wisdom:
“Be part of something, you cannot do it by yourself!”
And that’s exactly what #PCHF has been: a 2 years course, and a life-long friendship with likeminded HFenthusiasts! #heartfailure #graduation
@CardioZurich
@escardio – at Zurich, Switzerland
PCHF module 8: the final module!
Looking forward to learn from the giants one more time.
Fun, heart failure facts and a final graduation ceremony on Saturday.
Let’s get started! @CardioZurich @drsoli4030 @mjschuuring @BarandiaranHF – at Zurich, Switzerland
Check out this latest study performed at our lab @CardiologyUmcg ! Great example of translational research that holds potential to improve life of PLN-R14del cardiomyopathy patients @HanCardiomd @rudolf_debar – at Groningen, Nederland
Exciting breakthroughs in PLN-R14del cardiomyopathy! Our latest research has just been published in Circulation Research.
ahajournals.org/doi/10.1161/…
Laura Meems retweeted
Just published @NatureMedicine
Randomized trial of tirzepatide (Mounjaro) vs placebo *after* 12 weeks of intensive lifestyle intervention and >5% weight loss
nature.com/articles/s41591-0…
At 72 weeks, Placebo group gained 2.5% weight back; GLP-1 drug lost additional 18.4% body weight
@CardioZurich Module 7 acute #heartfailure was a blast!
Some wise words from Prof. @FRuschitzka himself: happiness is the delta between where you are and where you want to be. If the gap is not too wide, you’re doing pretty well!
#medtwitter #cardiology – at Zurich, Switzerland
Weight reduction by #ozempic or #wegovy @nosnieuws. If they would have dig a bit deeper they would have realized it is a DRUG 💊.
Quitting this drug without lifestyle changes = weight gain.
✅ breaking a vicious circle
❌ esthetic purposes/ lifelong therapy
#doyourhomework – at Groningen, Nederland
The word is out #ESC2023: in humans with HFpEF Semaglutide also improves Quality of Life and lowers NTproBNP. Proud that our preclinical studies could be confirmed
Gamechanger ⭐️ - #cardioobesity is real!! nejm.org/doi/full/10.1056/NE…
@HanCardiomd @MkosiborodMD @AndreasGevaert – at Ede, Nederland
Frustrerend deze advertentie in @LINDAmagazine over afvallen met #Semaglutide (#Ozempic).
1. Het is #medicijn, geen quick-fix
2. Game changer in obesitas 🏥 ☠️
3. Amper leverbaar vanwege grondstof tekort
@_LindadeMol volgend nummer tekst en uitleg over dit nieuwe medicijn?
Yes, semaglutide has beneficial effects in humans as well!
Our results in preclinical HFpEF published earlier this months suggested benefit. Very pleased to see that it’s potential in humans without HFpEF. Counting off the days to ESC! @novonordisk @AadVoerder #cardioobesity – at Ottignies-Louvain-la-Neuve, Belgique
#Semaglutide 2.4 mg reduces the risk of MACE by 20% in adults with overweight or obesity in the #SELECT trial
SELECT study baseline characteristics
👇🏻
onlinelibrary.wiley.com/doi/…
@novonordisk announced the headline results from the SELECT CV outcomes trial.
👇🏻
novonordisk.com/content/nnco…
Novo Nordisk expects to file for regulatory approvals of a label indication expansion for semaglutide 2.4 mg (Wegovy®) in the US and the EU in 2023.
Laura Meems retweeted
#Semaglutide 2.4 mg reduces the risk of MACE by 20% in adults with overweight or obesity in the #SELECT trial
SELECT study baseline characteristics
👇🏻
onlinelibrary.wiley.com/doi/…
@novonordisk announced the headline results from the SELECT CV outcomes trial.
👇🏻
novonordisk.com/content/nnco…
Novo Nordisk expects to file for regulatory approvals of a label indication expansion for semaglutide 2.4 mg (Wegovy®) in the US and the EU in 2023.
Laura Meems retweeted
#1
🐭💓 A new preclinical study from our institute ! @AadWithaar and @LauraMeems explored semaglutide in the context of #HFpEF
@rudolf_deboer
#MondayScientificSnack
Available online as per today - a preclinical study on the cardio protective effects of Semaglutide in HFpEF mice! 🧵 jacc.org/doi/10.1016/j.jacbt… – at Groningen, Nederland
3. Result?
Weight loss alone is not enough!Semaglutide 💊 = better cardiometabolic profile, cardiac structure, and cardiac Fx.
Transcriptomics +proteomics 🧬 = improved left ventricular cytoskeleton Fx & endothelial Fx + restored protective immune responses in visceral fat. – at Groningen, Nederland
4. In conclusion,
In HFpEF mice Semaglutide is better than fat reduction by dietary intervention!
Looking forward to human data from #STEPHFpEF presented #ESC2023 @escardio @rudolf_deboer @HanCardiomd @_antocannata @AndreasGevaert @MkosiborodMD – at Groningen, Nederland