Trying to learn something new today. Some days I do. Interested in cellular communication. GPCRs / G proteins --- Cell biology, Biochemistry & Pharmacology.

Massachusetts, USA
Joined June 2021
This one is not just about music
MILES DAVIS “Anybody can play. The note is only 20 percent. The attitude of the motherfucker who plays it is 80 percent.”
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I don’t know what the future will look like any more than anyone else but I do have one hope. I hope people retain their willingness to do hard things and the attention span to do them. Solving hard problems takes seriousness, focus, humility, resilience, vigilance — and sometimes beating your head against a wall repeatedly for a long time before anything interesting or fun happens. It frequently sucks. While I’m actually a huge fan of naïveté to embark on the impossible, superficial engagement will only generate mediocrity and incrementalism. And tenacity is required when things become predictably more complicated. There’s no cheap victory to be had. So even when complex or laborious things become much easier, I hope it supercharges our willingness and ability to think very deeply, to understand important nuance, to go far beyond surface level insights so truly meaningful progress can happen.
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Our GzESTY paper is online. We optimized a cell based assay to sensitively detect GPCR activation in response to ligand application or in complex mixtures containing endogenous ligands. GzESTY was designed to aid in GPCR deorphanization efforts. nature.com/articles/s41467-0… – at Brighton, NY
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I'm excited to share our lab's newest publication on the structure and pharmacology of GABA transporter 3 @NatureComms. Much to our surprise, GAT3 adopts an inward-open conformation in complex with the (moderately) selective antagonist SNAP-5114. #CryoEM rdcu.be/ei2KY
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We have innovated design of templates for CRISPR/Cas9 editing which allows efficient introduction of epitope tags in vivo. It is a simple hack which we hope to be broadly useful. Work by talented graduate student Chuanping Zhao. nature.com/articles/s41467-0…
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The emperor
the catclave has spoken
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“My guitar is my best friend.” — Django Reinhardt
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“You should never be comfortable, man. Being comfortable fouled up a lot of musicians.” — Miles Davis
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Excited to share our latest on ELFN1 mechanisms, a dysfunction of which leads to a devastating neurodevelopmental disorder. Swan song of @GPCRHenry. #GPCR , #Elfn1, @jbiolchem sciencedirect.com/science/ar…
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Check out this protocol for detecting endogenous GPCR activity in primary cell cultures using ONE-GO biosensors, by @MGMlab et al. @STARProtocols #CellBio2024 hubs.li/Q02_H8ZK0
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Yesterday the legendary Roy Haynes passed away at age 99… He was among the most recorded drummers in jazz. In a career lasting over 80 years, he played swing, bebop, jazz fusion, and avant-garde jazz. He is considered to have been a pioneer of jazz drumming… In this clip we see him performing a drum solo alongside the Stan Getz Quartet in 1966.
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Please RT and spread the word widely: Our department is hiring a tenure-track Assistant Professor in Global Change Biology (GCB), as part of a cluster hire in Global Change & Sustainability at Boston University: jobs.silkroad.com/BUCareers/…
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“Nowhere else are the battles so fierce because nowhere else are the stakes so small” —Henry Kissinger, describing the academic world @AcademicChatter
As a graduate student, I could never understand why faculty politics could be so nasty, personal, and vindictive. As an assistant professor, I wonder how I ever could have been so naïve.
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Dedicated to all my fellow scientists. It is nice when you are reassured that your gut instinct was right.
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YES!!
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Using a Doritos ingredient is wizard level of cool. I am corroded by (healthy) envy. Time to look at the list of ingredients of Cheetos and Fritos to come up with a sequel. Achieving optical transparency in live animals with absorbing molecules | Science science.org/doi/10.1126/scie…
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Remi Janicot and I wrote a review for @MolPharmJournal @ASPET on optical biosensors for #GPCR signaling. We tried to make something useful for choosing what assays to use depending on the questions you have (I am told the link is for 100 free pdfs) molpharm.aspetjournals.org/c…
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