Postdoc @ the Yanai lab @nyumedcompute, exploring cell state transitions in cancer. Also a proud mother, occasionally triathlete and a craft creator
New York
Joined September 2019
- Tweets102
- Following283
- Followers170
- Likes919
Maayan pour retweeted
🔥 In our new BioRxiv preprint we show how cancer cell adaptations along a proliferation–robustness axis drive TME pro-tumor phenotypes.
In this work, we asked whether cancer cell states are a result of a physiological response or adaptation to their microenvironment?
To study this, we performed long-term (36 weeks) co-culture experiments with cancer cells evolving alongside continuously replenished fibroblasts or macrophages.
This allowed us to distinguish between adaptive and physiological responses in specific cancer-TME interactions, which we then also recapitulated in patient tumors.
We found that co-culture with fibroblasts induced the epithelial-mesenchymal transition in cancer cells and resulted in their increased drug tolerance, while co-culture with macrophages promoted stress, hypoxia responses and enhanced tumorigenicity.
Adaptations were recurrent and partially reversible, but could not be explained by clonal selection, suggesting a dynamic non-mutational process.
Moreover, adapted cancer cells elicited cell state changes in the fibroblasts and macrophages consistent with an extended phenotype mode of cancer evolution.
Tremendous work by postdoctoral fellow Dr. Maayan Pour!
biorxiv.org/content/10.64898…
Maayan pour retweeted
Terror doesn’t distinguish Jews from Muslims. Israelis come in all religions and all colors, and all of us together are victims of #HamasISIS 💔🇮🇱
Maayan pour retweeted
Taking innocent children hostage is something only terrorists do.
It's been 19 days. At least 224 Israelis, including at least 35 children, are being held hostage in Gaza by Hamas.
#ReleaseTheHostages
Maayan pour retweeted
I just saw indescribable, raw footage of Hamas’ massacre along with 100 other international journalists, provided by Israeli authorities. Here are the notes I took:
1: Hamas terrorist screaming Allah Akhbah as he frantically tries to behead a dead man with a shovel.
Maayan pour retweeted
What kind of monsters would kidnap 3-year-old sisters? I'm begging you, this is above politics. Hamas won't hesitate to kill them. Please retweet and help us raise international awareness and pressure for the immediate release of Emma and Yuli. They are just little girls #HamasisISIS
Maayan pour retweeted
Hamas kidnapped more than 200 people, including babies and children. We need your help in bringing them back.
#hamasisISIS
Maayan pour retweeted
Israel did NOT attack the hospital in Gaza. This is conclusive.
Please take a minute to listen to a recording of a conversation by the Islamic Jihad Terror Organization about the failed rocket launch.
Maayan pour retweeted
Four minutes that every person should watch. @NYCMayor in an incredibly powerful speech that I will watch again and again these coming days.
We are so lucky at @nyulangone to have Orna's lab opening here!
Can't wait to hear about all the new discoveries.
If you are looking for an amazing mentor, highly recommend to apply
This Post is from an account that no longer exists. Learn more
Why are in-vitro embryo-like models so variable, while the embryo develops so robustly?
We try to tackle this in a new preprint, using the gastruloid model and morphogenetic progression of definitive endoderm (DE).
biorxiv.org/content/10.1101/…
Maayan pour retweeted
Why are in-vitro embryo-like models so variable, while the embryo develops so robustly?
We try to tackle this in a new preprint, using the gastruloid model and morphogenetic progression of definitive endoderm (DE).
biorxiv.org/content/10.1101/…
Maayan pour retweeted
Knowing how to give a good talk is a crucial skill to have, but it's mostly not formally taught very well. Here's a 🧵on my strategy for how to prepare for the presentation, actually present it, and then answer the questions.
Maayan pour retweeted
Tel Aviv friends: I can't wait to visit you tomorrow!
safrabio.cs.tau.ac.il/safrab…
So excited to see this out! An amazing work 👏 Congratulations to the team, Gal, @FKuperwaser, @AndrewPountain and @ItaiYanai
New paper🔥! How do macrophages respond to bacterial infection? We identify distinct states with a highly inflammatory state composed of sequentially expressed gene modules and dynamics that depend on the pathogen, infection length, & toxins.🧵@CellReports
cell.com/cell-reports/fullte…
Maayan pour retweeted
Cambridge/Boston friends: I'm looking forward to visiting Friday to present our latest work at @HSCRB on 'Cell state dynamics and plasticity in tumorigenesis and drug resistance'! nature.com/articles/s41588-0… tinyurl.com/24yt5jfj
Why not join in person like its 2019?!
Maayan pour retweeted
The "Cancer, Multicellularity, and Complex Systems" Symposium @lunduniversity is over, and it was a blast!
This was a truly interdisciplinary meeting; it was great to see how the very different backgrounds of the participants converged on the focal topics!
A summary🧵(1/24)
Maayan pour retweeted
🚀 OUT NOW @NatureGenet
📰 Cancer cell states recur across tumor types and form specific interactions with the tumor microenvironment
🧑🏿🤝🧑🏿 @ItaiYanai @BarkleyDalia and team
🔽
go.nature.com/3p7oSaU