Järås_Lab (@MarcusJaras) header
Järås_Lab (@MarcusJaras) profile picture

Järås_Lab

@MarcusJaras

We study cell surface receptors regulating hematological malignancies and develop new immunotherapies.

 Lund, Sverige
Joined October 2015
  • Tweets31
  • Following98
  • Followers133
6Media
Photo by Järås_Lab (@MarcusJaras)Photo by Järås_Lab (@MarcusJaras)Photo by Järås_Lab (@MarcusJaras)Photo by Järås_Lab (@MarcusJaras)Photo by Järås_Lab (@MarcusJaras)Photo by Järås_Lab (@MarcusJaras)
Our paper on Glut1 is published. Thanks for a great team-effort. ashpublications.org/bloodadv…
Combined GLUT1 and OXPHOS inhibition eliminates acute myeloid leukemia cells by restraining their...

Combined GLUT1 and OXPHOS inhibition eliminates acute myeloid leukemia cells by restraining their...

Key Points. GLUT1 is essential for energy metabolism of murine MLL::AF9 LSCs in the bone marrow microenvironment.GLUT1 and OXPHOS inhibition eliminates hum

ashpublications.org
7
302
Congratulations Sofia von Palffy for an excellent PhD thesis. Here at the ”Wall of Fame”, Clinical Genetics, Lund University.
Image from Järås_Lab (@MarcusJaras)
8
Our paper "IL4 promotes phagocytosis of murine leukemia cells counteracted by CD47 upregulation" is on line. Thanks for a great team effort! pubmed.ncbi.nlm.nih.gov/3395…
Interleukin 4 promotes phagocytosis of murine leukemia cells counteracted by CD47 upregulation -...

Interleukin 4 promotes phagocytosis of murine leukemia cells counteracted by CD47 upregulation -...

Cytokines are key regulators of tumor immune surveillance by controlling immune cell activity. Here, we investigated whether interleukin 4 (IL4) has antileukemic activity via immune-mediated mechan...

pubmed.ncbi.nlm.nih.gov
4
Den 4 november slår Studentafton upp dörrarna till en kväll om den Nobelprisbelönta gensaxen CRISPR/Cas9. Aftonen äger rum i Piratensalen på Grand Hotel i Lund och kommer att livesändas på Facebook. Länk till evenemanget: fb.me/e/1lzR8iqtw
Image from Studentafton (@Studentafton)
2
3
Our commentary about CRISPR in Swedish Läkartidningen is out: lakartidningen.se/klinik-och… Thanks to a great collaboration with the Pufendorf group CRISPRideas @PufendorfL
1
2
8
We are organizing a CRISPR symposium with David Liu as keynote speaker on Oct 13-14. Live-streamed.
Image from Järås_Lab (@MarcusJaras)
8
11
We are recruiting highly motivated postdocs - come join us!
Image from Järås_Lab (@MarcusJaras)
5
1
10
Our paper on in vivo CRISPR screens in leukemia stem cells is on line. Thanks for a great team effort that has involved many labs: cell.com/cell-reports/fullte…
CXCR4 Signaling Has a CXCL12-Independent Essential Role in Murine MLL-AF9-Driven Acute Myeloid...

CXCR4 Signaling Has a CXCL12-Independent Essential Role in Murine MLL-AF9-Driven Acute Myeloid...

In an in vivo CRISPR screen, Ramakrishnan et al. identify CXCR4 as a critical regulator of AML stem cells. Although the CXCR4 ligand CXCL12 is dispensable for leukemia development, CXCR4 signaling is...

cell.com
5
3
26
Niklas Landberg at the wall of fame after an excellent defense of his PhD thesis that was scrutinized by opponent Ulrich Steidl.
Image from Järås_Lab (@MarcusJaras)
1
7
Läs vår artikel om CRISPR i @SvDDebatt ”Vi måste ta ställning till nya gentekniken” svd.se/vi-maste-ta-stallning… @PufendorfL

”Vi måste ta ställning till nya gentekniken”

DEBATT. Genombrott för tekniken med så kallade gensaxar ger nya möjligheter att förändra och byta ut delar av arvsmassan. Nu krävs en bred samhällelig debatt om etiska, legala och politiska implika...

svd.se
2
1
8
Our recent review on NK cells in myeloid malignancies that I wrote with @CarlstenMattias is out: frontiersin.org/articles/10.…

Frontiers | Natural Killer Cells in Myeloid Malignancies: Immune Surveillance, NK Cell Dysfunction,...

Natural killer (NK) cells are large granular lymphocytes involved in our defense against certain virus-infected and malignant cells. In contrast to T cells, ...

frontiersin.org
3
10
We're presenting our research from the @MarcusJaras Lab at the ESH AML meeting in Estoril. Come to our posters about macrophages and CXCR4 in AML! #ESHAML2019
Image from pabsdoesscience (@pabsdoesscience)
Image from pabsdoesscience (@pabsdoesscience)
Image from pabsdoesscience (@pabsdoesscience)
Image from pabsdoesscience (@pabsdoesscience)
1
9
“Prime editing,” a new #CRISPR genome-editing tool, created by @davidrliu/@liugroup combines two key proteins and a new #RNA to make targeted insertions, deletions, and all possible single-letter changes in the #DNA of human cells. Learn how it works: broad.io/prime
Image from Broad Institute (@broadinstitute)
1
50
2
96
Prioritization of cancer therapeutic targets using CRISPR–Cas9 screens | Nature Exciting paper on whole genome CRISPR screens in more than 300 cell lines reveals synthetic lethality coupled to genetic biomarkers nature.com/articles/s41586-0…
2
11
Latest #TRACERx paper out in @nature - exploring how the immune system sculpts lung cancer evolution: go.nature.com/2CuGPZk . Big team effort @CharlesSwanton @StephanBeck6 @AndyFeber @SwantonLab @squezadd @MariamJHanjani @nbirkbak Blog here: bit.ly/2CujVRA
3
129
8
305
Our paper on arrayed molecular barcoding of leukemia cells for in vivo tracing is out. haematologica.org/content/ea…
1
1
7
Exciting CRISPR minisymposium next week with @zhangf. Ram will present our latest CRISPR work.
Johan Jakobsson (@JakobssonLab) profile pictureJohan Jakobsson@JakobssonLab20 Feb 2019
We are organising a minisymposium on CRISPR-technologies on March 6th in Lund. Don't miss! Honorary lecture by @zhangf ! Free registration: docs.google.com/forms/d/e/1F…
2
Ram presents our in vivo CRISPR screens and work on CXCR4 in AML at the ASH meeting in San Diego.
Image from Järås_Lab (@MarcusJaras)
1
6
Feng Zhang on gene-edited embryo work: "Not only do I see this as risky, but I am also deeply concerned about the lack of transparency surrounding this trial." fal.cn/S7Wv
Image from Broad Institute (@broadinstitute)
2
59
7
118
Excited to see that Csnk1a1 inhibitors in AML are moving towards the clinic.
NEJM (@NEJM) profile pictureNEJM
@NEJM14 Nov 2018
Acute myeloid leukemia is a genetically heterogeneous cancer that arises in hematopoietic stem cells. For the past 40 years, standard treatment for AML has consisted of a combination of two chemotherapeutic agents, cytarabine and an anthracycline. nej.md/2z0Mq7Y
Inhibition of Casein Kinase 1 Alpha in Acute Myeloid Leukemia | NEJM

Inhibition of Casein Kinase 1 Alpha in Acute Myeloid Leukemia | NEJM

Casein kinase 1 alpha targets the apoptosis-inducing protein P53 for degradation, and a paucity of functional P53 underlies the neoplastic behavior of cancers, including acute myeloid leukemia. Sup...

nejm.org
1
1
Load more