The question that drives our research @yalenus is to gain a better understanding of how #brains operate and generate #behavior; #mechanisms.
At E6, Yale-NUS labs
Joined April 2020
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Happy to announce our recent study on “Evaluating the inter-species transmission risk of amyloid beta peptide aggregates via ingestion” came online over the weekend.
rdcu.be/dKeoU
Fantastic to contribute to this exciting new development from @TirthaDasBaner1 and @MonteiroLab
Expect to see a lot more of RAM-FISH in your science newsfeed. Few other examples of multiplexed HCR on intact 14dpf zfish. 👍🏾
Ajay Mathuru retweeted
Our new manuscript describing gene multiplexing (using RAM-FISH) is finally out... We profiled multiple known and novel mRNA candidates during different developmental stages of Bicyclus and Danio. biorxiv.org/content/10.1101/… @MonteiroLab @MathuruLab
And, a big thank you to a fantastic ongoing collaboration with @TirthaDasBaner1 and Antónia Monteiro, on a number of projects. The spatial expression patterns studied uses a modified HCR tech perfected in-house allowing for expression analyzing in 2-3 week old z.🐟!
However, chrna3 mutants exhibited a prolonged attraction to alcohol and were less affected by alcohol exposure. These findings suggest that chrna3 dysfunction may contribute to acute alcohol tolerance, potentially playing a significant role in the development of addiction.
Our study employed a novel zebrafish self-administration assay to examine the role of chrna3 in alcohol response. Juvenile zebrafish displayed a biphasic reaction to alcohol, initially drawn to it but subsequently avoiding it.
chrna3 modulates biphasic response to alcohol biorxiv.org/content/10.1101/…
Our preprint on biphasic response to alcohol and the nicotinic acetylcholine receptor subunit chrna3 is out! The lay summary of our findings in the thread below.
Great to see what started out as a fun little 💬 with @jangruber467 and @ nicktolwinski a few years ago matured into the HLCA catalyst award and this paper! Congratulations to @ Josh Raine, on his first paper in the lab!
However, we conclude we need more research to fully ascertain if iatrogenic transmission by this route is possible when the Aβ sequence similarity between species is higher than it is between zebrafish and humans or there is a long incubation period.
This is great news given the prion-like properties of the amyloid-β, and the many reports of the propagation and spread of Aβ seed after intravenous or intracerebral inoculations.
Our study investigated dietary Aβ aggregates transmission, using a transgenic fly expressing human Aβ fed to #zebrafish. While there was no problem in detecting these aggregates in the feed, no Aβ transfer or pathology was observed in zebrafish gut or brains.
Evaluating the transmission risk of amyloid beta peptide via ingestion biorxiv.org/content/10.1101/…
The answer at the moment, thankfully, seems to be unlikely!
Read more ⬆️
A very useful update @SangyuXu, @adamcchang and everyone else involved.
We are already using it! 👍🏾
Ajay Mathuru retweeted
📢New paper out in #PNAS on mitochondrial control of microglial phagocytosis.
🧵A brief thread
pnas.org/doi/10.1073/pnas.22…
@PNASnews @NTU_LKCMedicine @NTUsg @alzforum
#mitochondria #microglia #Alzheimers #Immunometabolism
Check out the smchd1 story here. nature.com/articles/s41467-0…
Had not been thinking about homeotic transformations till this amazing study with @shifengxue and @ReversadeLab.
Congratulations 🎉 also to Raunak Vijayakar whose capstone thesis contributed to this publication. His 1st 📝!
Well done @shifengxue! Incredibly interesting work that has so many facets. It took some time, but really fantastic that you are finally able to share this with the rest of the scientific community. Congratulations @ReversadeLab and everyone involved! 👍🏽
Ajay Mathuru retweeted
Happy to share our latest work on the role of maternal SMCHD1 in regulating #HOX expression @NatureComms with @ReversadeLab @MathuruLab. This project survived a job change, maternity and pandemic. 🧵 nature.com/articles/s41467-0… 1/n
