The Mehl Lab develops genetic code expansion to site-specifically incorporate non-canonical amino acids (ncAAs) into proteins. (Twitter run by students)
Corvallis, OR
Joined June 2019
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Mehl lab member, Cat Vesely, has arrived at ASMS! She's excited to share her work at the @GCEcenter and in collaboration with @Agilent
We promise a good time! Looking forward to connecting with the GCE community!
🚨🚨All genetic code expansion enthusiasts, don’t miss the GCE 2024 conference this summer (gceconferences.org/)! Fantastic speakers both from academia and industry. Please retweet! @klanglab @Mehl_lab
Mehl lab retweeted
Check out our latest paper! Congrats on this amazing work @ZhuChemBio!
An autonomous E. coli system to genetically encode a functional nonhydrolyzable phosphoserine mimic into proteins is created and used to reveal how 14-3-3 phosphorylation rewires its interactome.
NEW #ASAP by Richard Cooley & team at @OregonStateBB
Read: go.acs.org/4Ra
Mehl lab retweeted
Join us this Thursday, May 18th for our International GCE Webinar to hear talks from Sharona Gordon (@ProfSharona) & James Petersson (@EJPLab) 10 am ET/2 pm GMT. Register now!! oregonstate.zoom.us/webinar/…
Happy #DamProudDay! Our department is raising funds for two $2,000 research fellowships, two $500 need-based scholarships, and to take a group of undergrad students to the National Diversity in STEM conference Oct. We appreciate any and all support!
damproudday.org/campaigns/bi…
Can't wait!!
We're excited to announce that we'll be hosting a 5 day intensive in-person workshop, Bioorthogonal Ligations - Clicking with GCE on Aug 8-12th 2023 in Corvallis OR. Open to all levels! Apply now! gceworkshops.org/
Mehl lab retweeted
Join us tomorrow, April 20th for our International GCE Webinar to hear talks from Andrea Cochran and Jeff Tharp (@jeffery_tharp) 10 am ET/2 pm GMT. Register now!! gce4all.oregonstate.edu/tool…
Mehl lab retweeted
Happy to share my major thesis project is officially online!
Autonomous Synthesis of Functional, Permanently Phosphorylated Proteins for Defining the Interactome of Monomeric 14-3-3ζ pubs.acs.org/doi/10.1021/acs…
#chemicalbiology #biochemistry #proteins
Our latest publication on 14-3-3 protein tyrosine nitration is out now in Protein Science @ProteinSociety. Great job @ZhuChemBio and team!! Great structures with near-atomic detail to look at fine-tuned structural changes.
14-3-3s are such cool proteins, and still have ambiguous function given how many other proteins they interact with. If you like PTMs, too check out my latest pub in @ProteinSociety journal Protein Science! These were my first structures ever solved!
doi.org/10.1002/pro.4574
Our pre-print on 14-3-3 oxidative stress and how it alters 14-3-3 protein structure and function is out now. A really great vignette on utilizing 2 GCE systems to tackle 1 biological problem.
Genetic encoding of 3-nitro-tyrosine reveals the impacts of 14-3-3 nitration on client binding and dephosphorylation biorxiv.org/cgi/content/shor… #bioRxiv
Congratulations to all the poster winners and our graduate student @ZhuChemBio for winning the poster prizes at the latest PS36 @ProteinSociety!
We're hiring! We currently have an opening for a Faculty Research Assistant- see the posting for details! jobs.oregonstate.edu/posting…
Mehl lab retweeted
Hey ya'll, I am looking for post doctoral work!! (finally) If you have any leads please let me know. Looking for structural biology, biochemistry postdocs. My linked in is here: linkedin.com/in/zhuph
Thank you in advance!!
Check out our latest paper in @ScienceAdvances where we create designer tetrazine-based anti SARS-Cov nanobody conjugations with very interesting results! When it comes to nanobody conjugation, control is key. #nanobody #chembio
science.org/doi/10.1126/scia…
Mehl lab retweeted
New Research: Creating a Selective Nanobody Against 3-Nitrotyrosine Containing Proteins: A critical step in developing therapeutics for oxidative stress-related pathologies is the ability to determine which specific modified protein species… frontiersin.org/articles/10.… #chemistry
Mehl lab retweeted
Check out the news on the new NIH Funded GCE4ALL Research Center @OSUScience @Mehl_lab @RyanAMehl1 #GCE4ALL #geneticcodeexpansion kval.com/news/local/osu-rece…
Mehl lab retweeted
Check out our new #NIHfunded center#GCE4ALL : gce4all.oregonstate.edu Congrats @RyanAMehl1
@Mehl_lab
A big congratulations to the newly minted Dr. Van Fossen who successfully defended her Ph. D yesterday morning! @FossenElise from the Mehl Lab. We are all so proud!
Check out our latest preprint on the design and application of a 21 amino acid organism which synthesizes and encodes the non-hydrolyzable analog of phosphoserine! @ZhuChemBio #chembio #syntheticbiology #biochemistry #biochem
PermaPhosSer: autonomous synthesis of functional, permanently phosphorylated proteins biorxiv.org/cgi/content/shor… #bioRxiv
Mehl lab retweeted
Latest findings from The Lueck Lab. Suppressor tRNAs work on endogenous CF causing nonsense mutations #nonsense #tRNAs biorxiv.org/content/10.1101/…
