NIHR Academic Clinical Lecturer in General Adult Psychiatry @UoS_Medicine. Interested in anxiety disorders and placebo effects
University of Southampton
Joined October 2010
- Tweets1K
- Following714
- Followers631
- Likes1.4K
Pinned Tweet
Our new review in @JAMAPsych: "Expectancy Effects, Failure of Blinding Integrity, and Placebo Response in Trials of Treatments for Psychiatric Disorders"
jamanetwork.com/journals/jam…
Thanks to co-first author @fusettoveronesi; @CorteseSamuele, @DavidBa42733370 & Matt Garner
🧵👇
Our new Insights article in European Neuropsychopharmacology!
We propose a framework for better design of control conditions for digital therapeutics for mental health conditions.
🔗 authors.elsevier.com/a/1l-8p…
@ecnptweets
#DigitalTherapeutics #MentalHealth #ClinicalTrials
It was great to present on placebo and nocebo effects in depressive and anxiety disorders in an educational update session at the ECNP Congress in Amsterdam. Many thanks to the educational committee for inviting me! @ecnptweets
Great to collaborate on this with @h_v_steenbergen! We found evidence that endogenous opioids mediate attentional broadening after receiving rewards.
Excited to share that our paper “Seeing the bigger picture: Endogenous opioids mediate attentional broadening after reward receipt” has just been published in Psychological Medicine!
universiteitleiden.nl/en/new…
Nathan Huneke retweeted
What can *genetic insensitivity to opioids* teach us about endogenous opioid function in humans?
Fully funded position in Oslo (PhD student or postdoc)
Please RT
Interested in pain, mu/kappa opioids, behavioural genetics, RCTs, or related? Apply here:
2411.webcruiter.no/Main2/Rec…
Nathan Huneke retweeted
Potential clinical academics are being lost to short term funding, lack of protected research time, and rising service demands... We are training some of the world’s brightest doctors, then encouraging them to walk away from the NHS and, in some cases, the UK entirely.
The UK is rapidly losing medical academics and without them the NHS 10 year plan is at risk. The upcoming NHS workforce plan is an opportunity to turn this shortage around according to MASC Co-Chairs David Strain and Jonathan Gibb: bmj.com/content/390/bmj.r180…
Nathan Huneke retweeted
Is psilocybin as effective for depression as it seems?
In a new meta-analysis we look at outcomes after treatment with three types of antidepressants: psilocybin, esketamine and SSRIs. Compared to their own control groups, psilocybin (ES/SMD: 0.70) is clearly more effective ->
Nathan Huneke retweeted
🧵Not Everything Is Withdrawal 🚨1/9
When ideology overshadows science, patients suffer.
A new systematic review in JAMA Psychiatry just released.
Let’s talk about what it shows-
and why the current withdrawal ONLY narrative risks harming patients. 1/9👇
Nathan Huneke retweeted
Trials of drugs for treatment resistant depression are like buses. You wait ages and then two come along at once. First the pramipexole phase 2 in The Lancet and now this.
Esketamine nasal spray as a monotherapy improved depressive symptoms in treatment-resistant depression (TRD) compared to placebo. ja.ma/3ZYkZIv
Nathan Huneke retweeted
🧵THREAD: Our new study published in #lancetpsych! We found that pramipexole augmentation substantially reduced depressive symptoms in patients with treatment-resistant depression over 48 weeks of treatment. This is an important advance in how we treat depression! 1/6
Nathan Huneke retweeted
This meta-analysis identified gaps in the reporting and representation of race and ethnicity in mental disorder pharmacotherapy trials. ja.ma/42L9tSx
Nathan Huneke retweeted
In our new study in @JAMAPsych led by the amazing @AlessioBellato from @unisouthampton, we analysed 1683 randomised controleld trials and found underrepresentation of certain racial and ethnic groups
jamanetwork.com/journals/jam…
Nathan Huneke retweeted
"How are race and ethnicity reported and represented across randomized clinical trials (RCTs) of pharmacotherapies for mental disorders?"
Check our paper just published in @JAMAPsych!
jamanetwork.com/journals/jam…
Nathan Huneke retweeted
Understanding Placebo Mechanisms to Reduce Attrition in Psychiatric Trials
jamanetwork.com/journals/jam… via @NathanHuneke et al
Nathan Huneke retweeted
Like alcohol and cannabis… but also no better than placebo?
The mixed messaging is staggering.
That alone should raise eyebrows- Prof is making it up as she goes along.
Hard to take seriously as science.
Its messaging for those wanting to just join the ‘antidepressants are bad’ bandwagon.
Our thoughts on missing data, statistics and placebo effects in psychiatric trials.
Thanks @CorteseSamuele and @solmi_marco! @JAMAPsych
jamanetwork.com/journals/jam…
Our editorial, led by @NathanHuneke, with @solmi_marco, in @JAMAPsych : "Understanding Placebo Mechanisms to Reduce Attrition in Psychiatric Trials"
jamanetwork.com/journals/jam…
Nathan Huneke retweeted
Expectancy effects and compromised blinding impact psychiatric RCTs. This review offers mitigation strategies. #PsychiatryRsearch PMID:40072447, JAMA Psychiatry 2025, @JAMAPsych doi.org/10.1001/jamapsychiat… #AI #Pharma #BioMed #RNA #ASHG #ESHG
Nathan Huneke retweeted
⚠️ ⚠️ Very important paper for #evidence #synthesis researchers ⚠️⚠️
Led by the amazing Corentin Gosling from @UParisNanterre
Out in Research Synthesis Methods
cambridge.org/core/journals/…
