@NatureAging

Nature Aging is a thematic Nature journal that serves the broad aging research community. Follows & RT ≠ endorsements.

 New York
nature.com/nataging
Joined March 2020
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  • Following573
  • Followers20K
149Media
🗞️Our October issue is live!✨Read about lipid remodelling and lifespan regulation; how age-related T-cell accumulation drives myelopoiesis; senescent B-cells in rheumatoid arthritis risk; exercise-derived vesicles promote cartilage health & much more! nature.com/nataging/volumes/…
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Online now!✨@kezhang2021 @xingjchen7 @f_monticolo @Salvato88775199 et al pair Raman imaging with spatial and single cell transcriptomics in aging and repair, and identify a lipid-linked Raman signature of p21+ cells @JianShuLab nature.com/articles/s43587-0…

RamanOmics decodes the spatial vibrational–molecular architecture of senescence in aging and repair

Nature Aging - Zhang, Chen, Monticolo, Sorrentino and colleagues pair label-free Raman imaging with spatial and single-cell transcriptomics to probe biochemical signatures of senescence in aging...

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📎 And read the News & Views written by Shuai Ma & Jing Qu nature.com/articles/s43587-0…

The chemical fingerprint of cellular senescence

Nature Aging - Senescence has traditionally been studied largely on the basis of changes in gene expression, but senescent cells also undergo profound biochemical remodeling. Zhang and colleagues...

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📎And now read the associated Research Briefing: nature.com/articles/s43587-0…

Cytotoxic CD4+ T cells support age-associated myelopoiesis

Nature Aging - Aging is associated with myeloid-biased hematopoiesis, which leads to the establishment of a pro-inflammatory microenvironment. We discovered that cytotoxic CD4+ T cells foster this...

nature.com
Nature Aging@NatureAgingAug 26
Online now! @EnriqueGab, @gsotoheredero et al identify an accumulation of cytotoxic CD4+ T cells producing CCL5 in the bone marrow during aging, linked to age-associated myelopoiesis. Blocking this axis improves healthspan in aged mice @MMittelbrunn nature.com/articles/s43587-0…

Cytotoxic CD4+ T cells induce age-associated myelopoiesis through CCL5–CCR5 signaling

Nature Aging - Gabandé-Rodríguez, Soto-Heredero and colleagues identify an accumulation of cytotoxic CD4+ T cells producing CCL5 in the bone marrow during aging, linked to age-associated...

nature.com
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🗞️Our September issue is live!✨Read about trained immunity driving inflammaging; senomorphic potential of CDK4/6 inhibitors; muscle grafts mimic exercise benefits; mtDNA drives ovarian inflammation; aging diseases dominate global health & much more! nature.com/nataging/volumes/…
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Could molecular diagnostics advance our understanding of Alzheimer's? Applications are now open for the 2026 MDx Impact Grants, supporting research on molecular markers of neurodegeneration using Seegene's high-multiplex PCR technology. go.nature.com/4r6o6KG

Nature Awards MDx Impact Grants

Nature Awards MDx Impact Grants Funds and tech to innovate syndromic PCR for a healthier world

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Online now! Cerrato et al propose a consensus roadmap towards precision senescence medicine, emerging from the SENESCENCE2030 meeting in Coimbra, Portugal earlier this year @marc_dema nature.com/articles/s43587-0…

A consensus roadmap from the SENESCENCE2030 network towards precision senescence medicine

Nature Aging - At the SENESCENCE2030 Annual Conference and Industry–Academia Workshop held in Coimbra, Portugal, in May 2026, researchers, clinicians, industry representatives and policy...

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Online now!✨@anamikaa_yadav et al develop a framework to quantify tissue structural aging, without training on chronological age, using GTEx histology image data, finding distinct and coordinated organ aging trajectories @Sanjusinha7 @sbpdiscovery nature.com/articles/s43587-0…

Mapping structural aging across human tissues reveals tissue-specific trajectories and coordinated...

Nature Aging - Yadav et al. develop a framework that quantifies tissue structural aging without training on chronological age, using a large dataset of human histology images. They reveal distinct...

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📎And now read the associated Research Briefing nature.com/articles/s43587-0…

Loss of cGAS disrupts H3K9me3 organization and derepresses LINE1 to cause inflammaging

Nature Aging - Age-associated inflammation, also known as inflammaging, has been associated with cGAS–STING signaling, and this pathway has been proposed as a potential therapeutic target....

nature.com
Nature Aging@NatureAgingAug 25
Online now!✨Martinez, Morandini et al identify a role for cGAS in chromatin organization: cGAS knockout mice show compromised heterochromatin organization, LINE1 depression, inflammation, and shortened lifespan nature.com/articles/s43587-0…

cGAS-deficient mice display premature aging associated with derepression of LINE1 elements and...

Nature Aging - Demonstrating a role for cyclic GMP–AMP synthase (cGAS) in chromatin organization, Martinez, Morandini and colleagues report that cGAS-knockout mice exhibit compromised...

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Online now! @EnriqueGab, @gsotoheredero et al identify an accumulation of cytotoxic CD4+ T cells producing CCL5 in the bone marrow during aging, linked to age-associated myelopoiesis. Blocking this axis improves healthspan in aged mice @MMittelbrunn nature.com/articles/s43587-0…

Cytotoxic CD4+ T cells induce age-associated myelopoiesis through CCL5–CCR5 signaling

Nature Aging - Gabandé-Rodríguez, Soto-Heredero and colleagues identify an accumulation of cytotoxic CD4+ T cells producing CCL5 in the bone marrow during aging, linked to age-associated...

nature.com
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@CSIC @CBM_CSIC_UAM
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Online now! In a World View, primary care physician Dean Ariel reflects on how conversations about geroscience unfold in his clinic, amidst the evolving landscape of public engagement with aging research nature.com/articles/s43587-0…

Longevity medicine cuts ‘desire paths’ in primary care

Nature Aging - Patients are arriving in primary care with questions about geroscience that medicine has not prepared clinicians to answer. Here, primary care physician Dean Ariel argues that the...

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Online now!✨Martinez, Morandini et al identify a role for cGAS in chromatin organization: cGAS knockout mice show compromised heterochromatin organization, LINE1 depression, inflammation, and shortened lifespan nature.com/articles/s43587-0…

cGAS-deficient mice display premature aging associated with derepression of LINE1 elements and...

Nature Aging - Demonstrating a role for cyclic GMP–AMP synthase (cGAS) in chromatin organization, Martinez, Morandini and colleagues report that cGAS-knockout mice exhibit compromised...

nature.com
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Online now!✨Wang et al report a role for CDK4/6 in regulating not only cell cycle progression but also the SASP, via retinoic acid signaling and NFkB. Targeting this pathway reduces inflammation and improves function in aged mice @Marc_dema nature.com/articles/s43587-0…

Disruption of CDK4/6–RARα–NF-κB axis attenuates senescence-associated inflammation and improves...

Nature Aging - Wang et al. report that the cell cycle regulators CDK4/6 also regulate the inflammatory phenotype of senescent cells, via modulation of retinoic acid signaling and NF-κB....

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✨Rajesh et al also report an unexpected role for the cell cycle regulators cyclin D1 – CDK6, as regulators of SASP via DNA damage and cGAS-STING. Blocking this pathway with palbociclib improves motor function and frailty in aged mice @AdamsBioAging nature.com/articles/s43587-0…

Inhibiting cyclin D1–CDK6 suppresses senescence-associated inflammatory gene expression and...

Nature Aging - Rajesh and colleagues report that the cell cycle regulators cyclin D1 and CDK6 regulate the inflammatory phenotype of senescent cells, via DNA damage and cGAS–STING activation....

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📎Liqin Wang & Rene Bernards discuss both studies in a News & Views nature.com/articles/s43587-0…

Turning CDK4/6 inhibitors against the dark side of senescence

Nature Aging - Senescence contributes to aging and cancer-treatment-related decline, and is increasingly viewed as a therapeutic target. In this issue, Rajesh et al. and Wang et al. identify cyclin...

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Register now for Reframing Precision Medicine: Innovation to Implementation, a flagship Nature Conference in London from 13–15 Oct 2026. Learn more at go.nature.com/471AdQb?utm_so…
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🗞️Our August issue is live!✨Read about fructose drives metastasis from senescent ovarian cancer cells; dietary valine restriction improves mouse healthspan, 5 blood proteins predict MASLD up to 16 years before onset & much more nature.com/nataging/volumes/…
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📎Now read the associated News & Views from Maz Divangahi & Katherine King nature.com/articles/s43587-0…

Maladaptive trained immunity as a hematopoietic stem cell driver of inflammaging

Nature Aging - A new study reveals that aging hematopoietic stem cells trigger a form of innate immune memory, known as trained immunity, that fuels the chronic low-grade inflammation that...

nature.com
Nature Aging@NatureAgingJul 16
Online now!✨Mu, Barthez, Feng, Chen, Wang et al report that trained immunity links hematopoietic stem cell aging to age-associated inflammation nature.com/articles/s43587-0…

Trained immunity links hematopoietic stem cell aging to aging-associated inflammation

Nature Aging - Mu, Barthez, Feng, Chen, Wang and colleagues report that SIRT3 suppresses the hematopoietic stem cell response to aging that drives maladaptive trained immunity, chronic inflammation...

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Online now!✨Cole et al identify fructose as a component of the therapy-induced SASP in senescent ovarian cancer cells and show that it reprograms cancer cells in paracrine, promoting detachment and metastasis @airdlab nature.com/articles/s43587-0…

The chemotherapy-induced senescence-associated secretome promotes cell detachment and metastatic...

Nature Aging - Cole and colleagues identify fructose as a component of the secretome in therapy-induced senescent ovarian cancer cells that drives metastasis. Fructose metabolically reprograms...

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