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En defensa del médico en redes sociales

Joined July 2015
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Qué escándalo…
Esto es un escándalo gigante. Los hermanos Hernández Casillas, que han ganado millones con contratos electorales, operaban mucho antes de la llegada de Taddei. Pero aquí viene lo más grave: ¿quién formó a estos personajes? ¡Un prominente militante de Somos! ¿Y quiénes están detrás de ese partido? ¡@lorenzocordovav y @acostanaranjo! La mafia electoral que se ha enriquecido a costa del @INEMexico y de los órganos electorales estatales también tiene casa en Somos. Aquí lo explica detalladamente la presidenta.
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Ozempic and Mounjaro beat Metformin at preventing prediabetes from progressing to diabetes, and they also seem to protect the heart. In health records from 256,492 people with prediabetes and obesity, people prescribed a GLP-1 drug had 31% less type 2 diabetes over about 3 years than those prescribed Metformin, along with 15% fewer heart attacks and 20% fewer strokes. Metformin still has solid evidence behind it. In 2002, it cut new diabetes by 31% compared with a placebo. The death number is the one to treat carefully. Deaths were 41% lower here, but Wegovy, a higher dose of Ozempic, cut heart events by 20% in a trial of 17,604 people. That gap probably reflects who gets these drugs, not a clean head-to-head result. The diabetes finding is backed by trial data. Over 3 years on Mounjaro, 1.3% of people with prediabetes developed diabetes, versus 13.3% on placebo. Bottom line: if your blood sugar is creeping up, ask your doctor whether a GLP-1 drug or Metformin makes sense for you.
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Os traemos el último trabajo de nuestro grupo en Reviews in Endocrine and Metabolic Disorders @SpringerNature sobre reganancia de peso tras el tratamiento de la obesidad con un programa estructurado @LorenaT_PhDc @cris88_pf @DiegoBellido2 @acrujeirasm Datos reales del programa IGOBE (n=124): a los 12 meses, quienes recuperaron peso partían de mejores hábitos basales. Lo que marcó la diferencia no fue el punto de partida, sino el cambio sostenido en el tiempo. La reganancia no es un fallo de voluntad ni de adherencia, es biología defendiendo el peso previo. Por eso el objetivo terapéutico debería ser el mantenimiento a largo plazo, no la pérdida inicial. 🧵 doi.org/10.1007/s11154-026-1…
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Obesity treatment is expected to shift gradually from a one-size-fits-all approach towards more personalised medicine, in which the obesity phenotype and presence of related conditions will determine the treatment strategy thelancet.com/journals/landi… #obesity
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Retatrutide phase 3 obesity trial just came out and the results are genuinely insane: - 28.3% bodyweight lost on 12mg over 80 weeks - 70.3 pounds on avg. or 31.9 kg - 45.3% of patients hit 30%+ weight loss (this is bariatric surgery territory) - 30.3% weight loss (85 lbs) at 104 weeks in higher-BMI patients - 65.3% of 12mg patients dropped below the obesity BMI threshold - 19% loss on 4mg over 80 weeks (47.2 lbs) with fewer dropouts than placebo (4.1% vs 4.9%) - significant drops in blood pressure, triglycerides, non-HDL cholesterol, waist circumference, and hsCRP - no cardiac or liver signals Retatrutide is going to completely overshadow tirzepatide and semaglutide, and take the throne as the best-selling drug of all time.
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HIPERINSULINEMIA COMO CAUSA DE OBESIDAD Y ENFERMEDADES CARDIOMETABOLICAS Revisión narrativa que aborda la cuestión. ¡¡¡A leer, zagales!!! Link en mi bio o waltersport.com/investigacio…
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Mientras tanto, la derechanguiza:
This quoted post is unavailable.
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🇪🇸 En los Carnavales de Cádiz se canta “Tango a Donald Trump”. Tienen que escucharlo, la letra es una maravilla. España y su humor político impecable, valiente, contundente. Llevo dos días escuchándolos y no deja de emocionarme.
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A new era in obesity treatment: medications like #semaglutide and #tirzepatide target hunger pathways, offering sustained weight loss of 15–21%. More potent therapies and next-gen biologics, dual and triple agonists, are under development. jamanetwork.com/journals/jam…
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Prediabetes remission without weight loss: a paradigm shift in diabetes prevention @NatMetabolism Un análisis post hoc del Prediabetes Lifestyle Intervention Study (PLIS) muestra que la remisión de la prediabetes sin pérdida de peso es posible y altamente protectora frente al desarrollo de DM2 ( ⬇️riesgo del 71%). 🔬 mecanismos Mejoría de la sensibilidad a la insulina. Aumento de la función de la célula β y de la sensibilidad β-GLP-1. Redistribución del tejido adiposo (subcutáneo vs. visceral) 🔗 nature.com/articles/s41591-0…
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👉Intensive Lipid-Lowering Therapy Following Acute Coronary Syndrome: The Earlier the Better 💔After an acute coronary syndrome (ACS), time is cholesterol. ⌛️Delaying intensive LDL-C lowering means leaving patients exposed at their most vulnerable stage. Evidence is compelling: •EVOPACS, PACMAN-MI, HUYGENS → Early PCSK9i + statins achieve LDL goals in weeks & stabilize plaques. •LAI-REACT → Triple oral therapy (statin + ezetimibe + bempedoic acid) cut LDL by ~60% within 1 week. ☝️Yet, in real-world practice, <50% of post-PCI patients reach LDL targets at follow-up, often due to inertia, underuse of combination therapy, or delayed lipid checks. The lesson is clear: ➡️ Do not wait for the first outpatient visit. ➡️ Start combination lipid-lowering during hospitalization. ➡️ Aim for <55 mg/dL (or even <40 mg/dL in recurrent events). 💪“Strike early, strike hard.” Early LDL-C reduction is not just about hitting numbers; it’s about plaque regression, stabilization, and preventing recurrent events when risk is highest. 🔓Open access mdpi.com/2308-3425/12/8/300# @society_eas
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3 types of hunger explained "simply" Hunger isn’t just about an empty stomach. Your brain receives signals from body composition, hormones, emotions, and even gut microbes. Here’s how the three major types work: 1️⃣ Homeostatic Hunger (Energy Balance Hunger) This is your body’s “fuel gauge.” It rises and falls based on energy needs and metabolic signals. What drives it: Ghrelin from the stomach stimulates hunger; leptin from fat cells and incretin hormones (GLP-1, PYY, CCK) reduce it. What it does: Ensures your intake matches your energy needs for exercise, growth, and tissue repair. 🟢 Example: After a long run, homeostatic hunger pushes you to replace calories and glycogen. 2️⃣ Hedonic Hunger (Reward-Driven Hunger) This is your “food pleasure” system. It’s triggered by sight, smell, habits, and emotions, not by actual energy needs. What drives it: Brain reward circuits activated by highly palatable foods (sugar, fat, salt). What it does: Encourages eating even when you’re not truly hungry. Weak satiety signals make it harder to stop. 🟢 Example: Craving dessert after dinner even though you’re full. 3️⃣ Microbiota-Driven Hunger (Gut Microbe Hunger) Your gut bacteria also shape hunger signals by producing metabolites that influence hormones and the brain. What drives it: Microbes generate compounds that mimic hunger or satiety signals, affect insulin, and modulate ghrelin, GLP-1, and PYY. What it does: Links gut health to appetite regulation and metabolic control. 🟢 Example: Certain bacterial imbalances may increase cravings or weaken satiety, nudging overeating.
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Nutritional Strategies for Reducing Postprandial Glycemia 1️⃣ Premeal nutrient intake modulates postprandial glycemia by delaying gastric emptying and influencing incretin hormone secretion, which is crucial for individuals with type 2 diabetes. 2️⃣ Protein is the most potent stimulator of glucose-dependent insulin secretion, enhances GLP-1 release, and reduces insulin clearance, improving metabolic efficiency 3️⃣ Dietary fat slows gastric emptying through potent intestinal feedback mechanisms, modulates insulin response, and enhances GLP-1 secretion when combined with protein. 3️⃣ Fruits may improve glucose tolerance via the Staub-Traugott effect, while fiber delays carbohydrate absorption, reducing postprandial insulin demand. 5️⃣ Almonds, rich in MUFAs and fiber, improve insulin sensitivity, delay glucose absorption, and may stimulate early-phase insulin release via pancreatic modulation. Strategic premeal nutrient selection is particularly important for individuals with type 2 diabetes to optimize glycemic control and metabolic outcomes. @DrNadolsky @TheAlanAragon @DrKarlNadolsky @drmatthewnagra Review Link: journals.viamedica.pl/clinic…
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Top 5 advances in medicine this week (🧵) 1. The GLP1 receptor agonist, Semaglutide, reduces cravings for alcohol and cigarettes This is a randomised phase 2 study with 48 patients The dose used was much lower than the dose for obesity, but still causes weight loss, so the trial was restricted to patients with BMI > 23 This could add new indications to a growing list of uses for GLP1s jamanetwork.com/journals/jam…
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The Sugar Queens: CGM Usage With Other Antidiabetic Medications teapaw.org/i/broadcasts/1rmxPovlo…
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Replying to @edelamadrid
Aquí no se necesita un ejercicio de imaginación, sino de memoria. Estás describiendo el sexenio de Miguel de la Madrid.
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CONADE me apoyo en varios torneos a lo largo de este camino , gracias
Di todo de mi en el ring, puse el corazón y el alma: Marco Verde El boxeador 🥊 conquistó la medalla de plata en la final de los 71 kg y significó un segundo lugar olímpico para México 🇲🇽 en esta disciplina después de 40 años. 👉 lc.cx/Kjti9d
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Para ti también, Ledolía Éste, ves?
Vulgar e insultante agresión gráfica de la entrevistadora rusa de AMLO/Sheinbaum contra el @INEMexico. No es periodismo, ni ella "periodista". Confío en que el INE tome nota.
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1. La candidata del #PRIAN y su equipo se perdieron la cabeza, aún más, después de su desastroso papel en el debate. 2. Ante ello se muestra tal cual es: #mentirosa, que utiliza las “groserías” para esconder su falta de propuestas. 3. ⁠Nuestra candidata ha aclarado el tema de los Panama papers. La cuenta es de su abuela y no hay nada ilegal. Hasta @davidpramo2, crítico a la 4T, lo comentó. 4. ⁠Nuestra candidata tiene en regla todas sus declaraciones patrimoniales; imposible decir lo mismo de la del frente. 5. Reiteramos: Este 2 de junio el pueblo de México tomara la sabia decisión de no regresar a la #corrupción y seguir con la #TRANSFORMACIÓN.
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