Principal investigator at the Azrieli Faculty of Medicine of Bar-Ilan University @biumedicine. Studying the cytoskeleton of the cilia #NewPI
Safed, Israel
Joined April 2020
- Tweets1.8K
- Following777
- Followers717
- Likes7.2K
Pinned Tweet
Delighted to share that we have secured our lab's FIRST grant! ๐ Our 5-year application to the Israel Science Foundation (ISF) has been selected for funding. Huge shoutout to the fantastic four reviewers for giving us the thumbs up! Now, off to do some epic science! ๐งช๐ก
The Orbach Lab would like to wish you a happy and healthy new year filled with thoughtful questions, exciting discoveries, productive collaborations, time to rest, and just enough surprises to keep science interesting.
Shana Tova!
๐ค Made with AI
๐จ I am very happy to share the first preprint from our lab! biorxiv.org/content/10.64898โฆ
This work started from a simple question: how do microtubule-inner proteins contribute to the stability and dynamics of ciliary microtubules? We focused on SPACA9, a conserved ciliary MIP, and used in vitro reconstitution to examine how it affects microtubule behavior.
ืื ืื ื ืืืืืกืื ืจืืฉ ืืืืืช ืืืงืจืืกืงืืคืื ืืคืงืืืื ืืจืคืืื ืฉื ืืจ ืืืื ืืฆืคืช! ๐ฌ
ืคืจืืื ื ืืกืคืื ืขื ืืืืืื ืืขื ืืืจืืฉืืช ืืชืคืงืื ืืืื ืง (ืื ืคืฉืื ืืืชืื ืื ืืคืจืื): medicine.biu.ac.il/node/8163
@biumedicine
Ron Orbach retweeted
๐ ๐ฒ๐ฒ๐ ๐ผ๐๐ฟ ๐ธ๐ฒ๐๐ป๐ผ๐๐ฒ ๐๐ฝ๐ฒ๐ฎ๐ธ๐ฒ๐ฟ๐ ๐ณ๐ผ๐ฟ #๐๐ถ๐น๐ถ๐ฎ๐ฎ๐ฌ๐ฎ๐ณ!
We are grateful for their participation and look forward to welcoming the cilia community on 8-12, March 2027.
Wishing you all a happy and inspiring 2026.
#Cilia #Milan
Ron Orbach retweeted
Reconnecting Israeli scientists to Israel:
Prof. @orlyavni , Dean, joined a senior scientific delegation to Europe, meeting researchers in Berlin, Zurich and Cambridge. The mission: open doors, build networks and show Israeli scientists abroad the opportunities back home.
Ron Orbach retweeted
Miao Gui and @OrbachRon summarise current structural and functional insights into conserved and lineage-specific MIPs, their roles in shaping ciliary architecture, and the consequences of their disruption on ciliary motility.
#JCSciliaSI
journals.biologists.com/jcs/โฆ
ALT Conserved MIPs. (A) 16 common MIPs that are conserved across almost all examined species. (B) Cross-section view of the location of the conserved MIPs within a DMT. (C) Longitudinal view of the eight conserved MIPs at the outer junction and seam region. (D) Longitudinal view of the six conserved MIPs at the inner junction. The figures are generated based on structure of DMTs from human respiratory epithelium cilia (PDB: 8J07). Black arrow indicates the position of the seam.
Ron Orbach retweeted
Ever wondered what microtubule inner proteins (MIPs) are and what they actually do? Or perhaps you already know about them, but find it hard to keep track of which ones are conserved across species and how they support ciliary structure and function?
journals.biologists.com/jcs/โฆ
Ever wondered what microtubule inner proteins (MIPs) are and what they actually do? Or perhaps you already know about them, but find it hard to keep track of which ones are conserved across species and how they support ciliary structure and function?
journals.biologists.com/jcs/โฆ
@miao_gui and I wrote a Review for @J_Cell_Sci special issue โCilia and Flagella: From Basic Biology to Diseaseโ. It provides a comprehensive and up-to-date overview of MIP structure, function, and the latest tools used to study them, crafted to serve both newcomers and experts
Ron Orbach retweeted
Thrilled to share our new work in Nature Neuroscience!
Together with amazing collaborators and led by Ariel Ionescu, we discovered that muscle-derived miR-126 controls local axonal TDP-43 synthesis and protects neuromuscular junctions in ALS.
nature.com/articles/s41593-0โฆ
Ron Orbach retweeted
FINALLY! This was challenging to publish but we believe it is an important discovery: rdcu.be/eATDa
๐ซThanks to the amazing team ๐ซ @bis_was_here @Omar136661 @KyoohyunK Carsten Hoege Benjamin Lorton @RainerNikolay @MatthewKraushar
@DShechter @GuckLab @VasilyZaburdaev
Ron Orbach retweeted
A huge milestone for the lab, and for me personally ๐ชThank you Israel Science Foundation #ISF for supporting our research on #nocebo effects in everyday life. We'll examine how health perceptions can causally shape physical health outcomes, and study the mechanisms involved.
Congrats to our #ISF 2025โ2026 grant recipients from the @Bar_ilan Azrieli faculty of medicine: Dr. @LironRozenkrant is exploring how subjective health perceptions impact physical health;
Prof. David Karasik is studying early bone development to prevent osteoporosis later in life; Prof. @ChaimPutterman is investigating a protein that may drive brain damage in lupus.
Ron Orbach retweeted
Congrats to our #ISF 2025โ2026 grant recipients from the @Bar_ilan Azrieli faculty of medicine: Dr. @LironRozenkrant is exploring how subjective health perceptions impact physical health;
Prof. David Karasik is studying early bone development to prevent osteoporosis later in life; Prof. @ChaimPutterman is investigating a protein that may drive brain damage in lupus.
Ron Orbach retweeted
A New study from @Bar_ilanโs faculty of medicine : Prof. @evanmelliott and Dr. Orly Weisberg & team discovered that Turning off the autism-linked gene CHD8 in adult brain immune cells (microglia) โ not neurons โ led to autism-like behaviors in males. A surprising twist in autism research, highlighting sex differences and the brainโs immune system.
Ron Orbach retweeted
So apparently a lot of people don't know this, but your Rods and Cones in your eyeballs all contain Microtubule Cilia
So some of the first interactions that light has with your Conscious perception, is in Microtubules - that's a big clue
Ron Orbach retweeted
Conformational flexibility of tubulin dimers regulates the transitions of microtubule dynamic instability biorxiv.org/content/10.1101/โฆ #biorxiv_biophys