Co-founder, President & CSO, Aleta Biotherapeutics, https://xitter.cf/t.co/vyLXDleOdp - Founder & Principal, SugarCone Biotech, commentary at https://xitter.cf/t.co/nE18E8qx8B

Holliston, MA
Joined December 2012
Oh...! Alice Cooper has a gift for the written word
Just started Alice Cooper's autobiography. Already I can tell its going to be excellent. This is NOT going to be the usual "wild men live crazy" rock & roll read.
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integrin targeting with a small molecule -> the data look very good. cf. Eli Lilly's MORF-057 which came via the Morphic acquisition (ps. emvistegrast is an alpha4beta7 inhibitor)
$ABVX -5% premarket because nothing goes right for $ABVX Umer calls emvistegrast a "foundational asset" based on UC data. And the $ABBV combo data also strong.
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i think the key to successful reemergence on X is aggressive use of the mute and block functions
I’ve been quiet on this app for two years with no regrets, but I’m cautiously willing to give it another try.
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Paul D. Rennert retweeted
Christmas Card (South Truro Church) - after 1930 #artbots #hopper
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I'm a keen supporter of @ABCbirds keep it up!
Home Tweet Home. 🌎 It’s World Habitat Day, a day to recognize the places that make life possible. For birds, habitat isn’t simply where they live — it’s where they find food, shelter, nesting sites, and places to rest and refuel along their journeys: abcbirds.info/3W2IoJq
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quote from Ozark season 1 "some rooms are smarter than others" (sez Marty) I'll just go ahead and agree here ... @netflix
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Act Local, Think Global. The Truro Conservation Trust is focused on land protection in the face of the relentless development pressure facing the outer Cape. truroconservationtrust.org/
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Looking forward to the Mass Audubon Broad Hill Sanctuary event this weekend. Their strategy of directly protecting critical habitats is a key part of environmental action. You can help @ massaudubon.org/
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saw a Crested Caracara today in Wellfleet MA, a massively misplaced bird. Last one I saw was in Northern Mexico, where they belong #birder very cool... pic from wikipedia
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Hey New England if you heat your home with oil best buy a contract asap --> 70% average increase in $/gallon vs last heating season ps. if you heat with gas, well, good luck
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Paul D. Rennert retweeted
Thrilled to present at #MSS2026 in Slovenia 🇸🇮 on how #GeneEditing Therapeutics address Unmet Medical Needs. It’s been an inspiring event covering the cutting edge of Gene Therapeis, #CGT,  #Vaccines, Delivery, and  Biomanufacturing.
🤖 Made with AI
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Amazing recent advances in the design of multi-specific engager proteins from @AletaBio and many other exciting labs and companies will be presented at World Bispecific this week ---> #Costimulation #CARTcells #Boston #Seaport bispecific.com/
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Paul D. Rennert retweeted
BREAKING: Trump has a Stage 5 nuclear meltdown after he got exposed for lying about visiting Ground Zero on 9/11 — forcing him to finally admit the truth for once! This is the guiltiest that this lunatic has ever sounded... "The Failing New York Magazine wrote a story that I wasn’t down at the World Trade Center after the Tragedy of September 11th, because nobody saw me there," Trump wrote on Truth Social. "Well, I don’t think I would be the first thing on anyone’s mind but, I was there, obviously not on the same day as the collapse, but shortly thereafter, with a large group of Construction Workers." His admission that he wasn't there on the "same day as the collapse" flies in the face of his assertions and implications that he was. Just yesterday, at an event to commemorate the victims no less, he stated that he went to the site "right" after the attack happened and then had to be carried to safety by "big strong" firemen because another building looked ready to collapse. New York Magazine covered the lie in an article entitled "Trump Tells Weird Lie About Where He Was on 9/11" in which they bluntly fact-checked him. "I discussed it today during my Remarks on the Ellipse, in Washington, D.C., for Tunnel to Towers. Everything I said was exactly accurate and, to prove the point, I am attaching clips of me there with numerous of my people, including my then Head of Security, Matthew Calamari, who has confirmed that very sad trip to Lower Manhattan, many times, to many different Journalists, but it’s a story that just won’t die," Trump continued. Of course, nobody has denied that Trump visited the ruins of the World Trade Center a few days after the attack, once the worst of the danger had passed. There are indeed photos of him doing so. But that's not what he claimed. He said that he was down there “right after this happened" and is now backtracking because it was such a blatant lie. "The Fake News doesn’t want to listen, even when they know their story is false. That’s why their approval ratings are at an All Time LOW, but mine are VERY HIGH!" Trump continued. "On another September 11th front, Maggot Hagerman continues to say that I did not go to the New York World Trade Center event, but the Pentagon instead, because they wouldn’t let me speak in New York. Maggot knows that this is a lie! I have been to the New York solemn ceremony numerous times, and nobody speaks. It is a stated fact that, 'Politicians and public officials are not permitted to deliver speeches or remarks at the official September 11 anniversary remembrance ceremony at the World Trade Center site in New York.'" Again, Trump is lying. Maggie Haberman is a respected, credible journalist whereas the President is a pathological liar. She reported, after speaking to reliable sources, that Trump refused to attend the event in question because he wouldn't be allowed to give a speech. We have no reason to doubt her and every reason to believe that Trump is lying in a desperate scramble for damage control. Just because he can quote the National September 11 Memorial & Museum's rules doesn't mean that he didn't try to violate them. "Certainly I would not want to violate that, even if I could," Trump wrote. "I speak enough, and it just so happens that the strong request was made for me to be at the Pentagon instead, with VP Vance handling our Administration’s representation in New York. Hagerman, unattractive both inside and out, fully knows that her story is made up. She knows less about me than the average reporter 'on the beat.' I haven’t spoken to her in a long time, and certainly there was no 'fact checking' for her story — There never is! Let her reveal her sources, because they don’t exist." The irony of Trump attacking anyone's looks was apparently lost on the President. Just take a look at literally any photograph of him. People in glass houses shouldn't throw stones. "Again, speeches are not made at the New York event and, even if they were, I never asked to speak," Trump continued. "Fake News is getting worse and worse in the U.S.A. It’s very important to comment so that people understand what liars and scoundrels these so-called 'journalists' are. They’re angry, and sick, over the fact that I won the Presidential Election three times! I hereby demand a retraction from Maggot, and also, for whoever wrote the fake story for New York Magazine. Again, check out the clips of me at the World Trade Center site. I was there as soon as the Law allowed. Thank you for your attention to this matter. President DONALD J. TRUMP" Clearly, these damaging reports have struck a nerve with a man who realizes that he can scarcely afford more scandals given his anemic approval ratings. He's fixated on these stories because they're true and they reveal him to be a cruel, ugly man who views nothing as sacred. For their part, The New York Times is standing by Haberman's reporting— “We won’t be issuing a retraction. This is another all too common example of the president lashing out at coverage he doesn’t like and belittling journalists who report the facts," the newspaper told the Independent. “Readers can follow our coverage of the president’s 9/11 plans here, and the evolving – and often disputed – account of his actions on September 11 here.” Please ❤️ and share if you refuse to let Trump wriggle off the hook for this lie!
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wow
$ABBV RC148 (ABBV-1480) + chemo in 1st-line NSCLC. Squam: ORR 90%, PD-L1<1% ORR 93%, "exceeding $SMMT ivonescimab's 71% in Harmoni-6". Non-squam: ORR 76%, PD-L1<1% ORR 71%. #WCLC26
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Paul D. Rennert retweeted
Great discussion with one of the leading voices in Washington on biotech. FDA, China, NIH - all the key topics discussed here.👇
𝐓𝐡𝐞 𝐈𝐬𝐬𝐮𝐞𝐬: @RepAuchincloss discusses the economic impact of biotech, global competition, and efforts he is taking to solidify funding, modernize regulation, and keep the United States on top. With @MassBio CEO @KendalleOC. Full video: biotechtv.com/post/congressm…
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awesome work! @BioAleta we asked why antibody-driven costimulation so often fails - CD28, CD2, 4-1BB etc - and we found the answer within the immune synapse. We've built the solutions into our T cell engagers and CAR T engagers...
New work by @PaulosLab with Dr. @AyanaTRuffin at the helm! B cells inspire the generation of potent CD8 T cell therapy via CD2 signaling. Nifty. Practical. Impactful.
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A sartorial observation: there is not a proper cuff length in sight. Gents, find a proper tailor.
Trump, running late, is making these people uncomfortably fidget around while they stand around
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