Father of Eva and Adele, husband of Ariane. Teacher and researcher at @unipr: biochemistry & bioinformatics, metabolic pathways, coevolution.
Parma, Italy
Joined June 2009
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Over a century after Garrod's pentosuria, we found how L‑xylulose is formed in the pentose pathway via coevolutionary analysis of KEGG networks. A long-standing metabolic gap bridged in @PNASNews. #Bioinformatics #Genomics #Biochemistry #Metabolism pnas.org/doi/10.1073/pnas.25…
Recovering signatures of archaic hominin introgression using ancestral recombination graphs | Science science.org/doi/10.1126/scie…
Riccardo Percudani 🐳 retweeted
Research highlight @Percud: Urate metabolism, in the gut academic.oup.com/lifemeta/ar…
A novel component of the CatSper ion channel (Armh2) uncovered! Great collaboration with @JeanJuChung and @jianpingwu8
nature.com/articles/s41467-0…
Great new machine learning study from @unipr researchers:
Read it here 👉 doi.org/10.1007/s10994-025-0…
Using bioinformatics for identifying and plugging metabolic pathway holes | PNAS pnas.org/doi/10.1073/pnas.25…
Riccardo Percudani 🐳 retweeted
Deep-learning-based single-domain and multidomain protein structure prediction with D-I-TASSER go.nature.com/4kwCaIK
Predicting Protein Function in the AI and Big Data Era | Biochemistry pubs.acs.org/doi/10.1021/acs…
Riccardo Percudani 🐳 retweeted
EvoWeaver provides as output its 12 predictions for signals of coevolution, and can optionally provide an ensemble prediction using built-in pretrained models. Functional associations often result in correlated gain/loss patterns on a reference phylogenetic tree.
Riccardo Percudani 🐳 retweeted
"It's not a goal that is the goal, it's actually the path towards the goal."
2014 chemistry laureate Stefan Hell shares his best career advice for young scientists and researchers.
#NobelPrize
Riccardo Percudani 🐳 retweeted
Will soon open a position in my group in Padova. Topic is mechanistic enzymology with cool serial X-ray, electron and neutron crystallography work... plenty of opportunities for collaborations with leading groups. Get in touch with me [email protected] if interested.
Pierre-Régis Burgel presenting the keynote speech at the 22nd convention of investigators in Cystic Fibrosis.
Mitochondria never cease to amaze
How do mitochondria, the cell’s energy-producing organelles, perform competing metabolic processes?
Segregation into distinct populations — one that makes energy-storing ATP molecules and one that does not — could explain it
nature.com/articles/d41586-0…
Our #bioinformatics course assistants love using ChatGPT visuals in the computer lab exercises. I found this #BLAST visual quite punching!
Riccardo Percudani 🐳 retweeted
This year’s medicine laureates Victor Ambros and Gary Ruvkun studied a relatively unassuming 1 mm long roundworm, C. elegans.
Despite its small size, C. elegans possesses many specialised cell types such as nerve and muscle cells also found in larger, more complex animals, making it a useful model for investigating how tissues develop and mature in multicellular organisms.
Read how the 2024 medicine laureates’ investigations into C. elegans revealed an entirely new dimension to gene regulation: bit.ly/4dlPE6f
#NobelPrize
Riccardo Percudani 🐳 retweeted
Link: blog.atomsonly.com/p/estimat…
Also, I previously tweeted about this story, so you may have already heard about it. teapaw.org/NikoMcCarty/status/173…
High-resolution cryoEM structure of UapA, the original member of the NAT transporter. While UapA transports uric acid, other members of this family transport ascorbate. Linus Pauling proposed an evolutionary connection between uric acid and ascorbate (vitamin C)
📢New lab preprint: 2.05 A #cryoEM structure of UapA: unprecedented aspects of the elevator-type transport (incl. water, lipids) and regulatory roles of the N-tail. With Diallinas, Mikros labs. Kudos @broutzakis and all co-authors. @uni_muenster #SoN
biorxiv.org/content/10.1101/…
2024 ISCB Innovator Award recipient, Dr. Sui-In Lee, concludes the #ISMB2024 congress with a powerful message: the researchers' goal is not to publish in prestigious journals, but to push the boundaries of human knowledge.
