@PontilloD_

Biostatistician Department of Anesthesia and Intensive Care of @SanRaffaeleMI

 Milan,IT
Joined February 2024
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  • Followers153
4Media
🚨 Our fantastic #RCT just published in @NEJM! 🚨 🩸 Can Acute Normovolemic Hemodilution (ANH) reduce RBC #transfusion in cardiac surgery? 🫀 ❓ What were the results? Click to find out 👉 nejm.org/doi/full/10.1056/NE… #CardiacSurgery #NEJM #PerioperativeCare
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Edoardo@e_mongardiniOct 19
Acute normovolemic hemodilution in women undergoing cardiac surgery: less transfusion? No. Post hoc analysis of the ANH RCT, 405 women: - RBC transfusion 38.8% vs 44.6% (RR 0.87, 95% CI 0.69–1.10) - hypotension 16.0% vs 4.8% - ICU stay +21 h Would you still use ANH in women?
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Giovanni Landoni, MD@giovannilandoniOct 16
After our ANHtrial in @NEJM we focused on blood transfusion in women #ANH vs usual care in #cardiacsurgery 🩸 RBC transfusion 38.8% vs 44.6% (NS) ⚠️ Hypotension 16.0% vs 4.8% 🏥 +21h ICU, +1.9 days hospital Caution with ANH in women. Now in @JAMASurgery doi.org/10.1001/jamasurg.202…
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Giovanni Landoni, MD@giovannilandoniOct 9
🥇 Con oltre 1.000 preferenze, Anestesia e Rianimazione si conferma la disciplina più scelta in Italia! Ai neoimmatricolati auguriamo 5 anni di specialità ricchi di crescita, competenze e soddisfazioni. Benvenuti! 💚 #Anestesia #Rianimazione
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Rosa Labanca@RosaLabanca5Sep 18
@Stefano__Turi @SFresilli @PontilloD_ @FedericoMOliva @s_vietri @GaeLombardi
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Rosario Losiggio, MD@LosiggioRosarioJun 12
#CCR26 is over! 12 outstanding RCTs presented! 😍Save and share this figure to keep a concise overview of the key information! 🎨 Color coding reflects my personal overall interpretation: 🟢 Benefit ⚪ No difference 🔴 Harm Few practice-changing results but plenty to discuss!
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Rosario Losiggio, MD@LosiggioRosarioJun 11
The #FISSHtrial has now been presented at #CCR26 In >1100 high-risk septic shock pts, Ringer’s Lactate did not reduce 30d mortality compared with saline (33.6% vs 33.0%) Interesting signal in patients with more severe #AKI! First major RCT without a simultaneous publication?
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Rosario Losiggio, MD@LosiggioRosarioJun 11
🚨 Just published in @NEJM and presented at #CCR26. The #ARISEFLUIDStrial (n=1,000) found that early vasopressors with restricted fluids did not improve days alive and out of hospital at 90 days vs a more liberal fluid strategy! ⚠️ Less pulmonary edema, though (0.6% vs 5.0%)!
DHOH90 76 vs 76, MD 0.0, p=1.00

ALT DHOH90 76 vs 76, MD 0.0, p=1.00

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Rosario Losiggio, MD@LosiggioRosarioJun 10
🚨 Just published in @NEJM and presented at #CCR26 The #LOGICALtrial (n=1,840) tested whether conservative vs liberal O2 therapy could improve 180-d neurological outcomes after cardiac arrest It did not!: 38.2% vs 39.7%; RR 0.97, 95%CI 0.87–1.09 #CardiacArrest #CriticalCare
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NEJM
@NEJMJun 1
Original Article: Daraxonrasib or Chemotherapy in Previously Treated Metastatic Pancreatic Cancer (phase 3 RASolute 302 trial) nej.md/4nWaxvM #ASCO26 | @ASCO
A two-panel line graph shows overall survival in two populations, comparing darovasertib (blue line) and chemotherapy (gray line) treatments. Panel A depicts the RAS G12 population, while Panel B shows the overall population. Hazard ratios and confidence intervals are detailed in each panel.

ALT A two-panel line graph shows overall survival in two populations, comparing darovasertib (blue line) and chemotherapy (gray line) treatments. Panel A depicts the RAS G12 population, while Panel B shows the overall population. Hazard ratios and confidence intervals are detailed in each panel.

This image shows two line graphs titled "Progression-free Survival in the RAS G12 Population" and "Progression-free Survival in the Overall Population." Both graphs compare survival rates over 13 months between two groups: one receiving darovasertib and the other receiving chemotherapy. Accompanying the graphs are tables detailing the number of events and patients at risk for each treatment group.

ALT This image shows two line graphs titled "Progression-free Survival in the RAS G12 Population" and "Progression-free Survival in the Overall Population." Both graphs compare survival rates over 13 months between two groups: one receiving darovasertib and the other receiving chemotherapy. Accompanying the graphs are tables detailing the number of events and patients at risk for each treatment group.

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Rosario Losiggio, MD@LosiggioRosarioMay 28
Today I had the honor of participating as a speaker at the 37th SMART Congress. It was a great opportunity to discuss the new frontiers of acute kidney injury, including early diagnosis, precision medicine, and the potential role of emerging biomarkers. Ad maiora! 💙
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Giovanni Landoni, MD@giovannilandoniMay 28
in milan, @LosiggioRosario is presenting on renal buomarkers @Smart_Meeting_M
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Giovanni Landoni, MD@giovannilandoniMay 14
Dear Ozgun @OzgunOasiller , You had a beautiful mind, and you were only 30 years old. Last year, you spent weeks in our hospital as an ESAIC mentee from Ankara. In that short time, you left a mark on all of us. We miss you deeply.
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🚨 New publication alert using TriNetX real-world data 👥 >100,000 young adults with septic shock ⚖️ Propensity-matched cohort ♀️ Women aged 18–55 had lower 28-day mortality than men: RR 0.92 (95% CI 0.89–0.95) ⏳ After age 55, this difference disappeared 🔗doi.org/10.1016/j.jcrc.2026.… @JCriticalCare @giovannilandoni @alebelletti1 @SFresilli @RosaLabanca5 @mariottichia_ #TriNetX #RealWorldData #SepticShock #CriticalCare
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The #PROGRESStrial protocol is out: an ongoing multicenter RCT testing whether a prehabilitation program can reduce major postoperative complications and facilitate recovery in patients undergoing major oncological gastrointestinal surgery. 🏋️‍♂️ 🔗 pubmed.ncbi.nlm.nih.gov/4162…
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Giovanni Landoni, MD@giovannilandoniFeb 24
This article on #AMINOACIDS for prevention of #AKI is more important than our @NEJM Hundreds of centers which are implementing perioperative AA based on the #PROTECTIONtrial and European guidelines should limit the duraton of infusion of AA to<=48 h authors.elsevier.com/a/1mg9T…
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Rosario Losiggio, MD@LosiggioRosarioFeb 19
Today at #ITACTAIC2026 in Bologna, great insights on the “hub & spoke” model for cardiogenic shock, current evidence and future perspectives to build faster, more integrated, multidisciplinary networks 👏 @MarinaPieri5
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In this secondary analysis of the #PROTECTIONtrial, the renal protective effect of amino acid infusion after cardiac surgery was similar in diabetic and non-diabetic patients, supporting its use for all patients undergoing cardiac surgery. 🔗 pubmed.ncbi.nlm.nih.gov/4151…
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Matteo Borello@BorelloMatteoFeb 3
Domani verrà pubblicato su YouTube e Spotify il primo episodio di PodcAnest, un podcast sviluppato dal CPAR a cui ho collaborato Lo scopo di spiegare il mondo dell’Anestesia e Rianimazione ai non medici e agli studenti di medicina Il primo episodio parlerà di Donazioni d’organo
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In our meta-analysis including 34 trials and >5000 patients, ANH did not reduce the proportion of cardiac surgery patients who received allogeneic pRBC transfusions during the postoperative hospital stay 🩸 📎 @BJAJournals pubmed.ncbi.nlm.nih.gov/4155…
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🎉 Congratulations to the Xijing Hospital: top 2026 enrolling center in the #LUNAtrial! Thank you to the ACRC & the Cardiac Anesthesia Team for their outstanding work. Special recognition to Prof. Chong Lei, PI, for exceptional leadership in high-quality clinical research!
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