@ProiaLab

Our own opinions 🔬👩🏻‍🔬🐭 👨‍🔬👩🏻‍💻📚#sphingolipids #metabolism #signaling #genetics #LysosomalStorageDisease #neurodegeneration #MouseModels

 Bethesda, MD
niddk.nih.gov/about-niddk/staff-directory/biography/proia-richard
Joined January 2018
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Do microglia and/or neurons contribute to Gaucher disease? insight.jci.org/articles/vie… Hannah Duffy, Colleen Byrnes, et al. use cell-specific deletion models to answer the question. Image: specificity of the Gba deletion in microglia (left) and neurons (right). @ProiaLab @NIDDKgov
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#NationalDNADay commemorates the completion of the Human Genome Project in 2003 and the discovery of the double-helical structure of DNA in 1953. 📸 #TheLadder @ NIH campus
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Lipid structure matters in lysosomal storage disease sciencedirect.com/science/ar…
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Sialidase NEU3 action on GM1 ganglioside is neuroprotective in GM1 Gangliosidosis buff.ly/3QJQvFT (@jlipidres)
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We also play music 😍 #MusicInTheAtrium
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🔬#LRMSRC is an unmissable opportunity to discuss the biology of lysophospholipids. Join us, share your research and learn from the world experts in the field @hlatim @ar_dilorenzo @ProiaLab @CChristoffer78 web.cvent.com/event/6c972c32… #Lysophospholipids #FASEBconferences – at Melbourne, FL
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SARS-CoV-2 can harm the brain. Our study found ORF3a, a key protein of the virus, led to COVID-19 neuropathological features in mouse brains. ORF3a disrupted autophagy-lysosomal pathway & caused neuronal accumulation of factors linked to neurodegenerative disease. #sphingolipids
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faseb.onlinelibrary.wiley.co…

SARS‐CoV‐2 ORF3a expression in brain disrupts the autophagy–lysosomal pathway, impairs sphingolipid...

SARS-CoV2 ORF3a brain expression in mice caused impairment of the autophagy–lysosomal pathway, neuronal accumulation of α-synuclein and glycosphingolipids, neurodegeneration, glial activation, and...

faseb.onlinelibrary.wiley.com
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Childhood amyotrophic lateral sclerosis caused by excess sphingolipid synthesis. Mutations disrupt the normal homeostatic regulation of serine palmitoyltransferase by ORMDLs. @NatureMedicine nature.com/articles/s41591-0…
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Seen on ⁦@NIH⁩ campus this morning. Watch out mice! #NIHFox
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Robert Lefkowitz ⁦@the_asci⁩ and AAP talks about the old ⁦@NIH⁩ in the era of the Yellow Beret, circumstances of medical training that led to multiple Nobel prizes and what is different today.
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Monocytes secrete signaling lipid S1P in lymph nodes to control the immune response go.nature.com/30bTID8
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Alzheimer's risk allele APOE4 disrupts intracellular lipid homeostasis in glia stm.sciencemag.org/content/1… Congrats @narayan_pri
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Tonight on #MitoMonday, we briefly highlight the life and works of pioneering geneticist, living legend and authority on inborn errors of metabolism, Elizabeth F. Neufeld. #LateNightWithTheRutterLab
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We are starting 2021 with a SphingoLeader talk by @ProiaLab! Don't miss this great talk! Register at sphingolipidbiology.com/regi… to attend the live webinar and be elegible for an @AvantiLipids Coffee Break Giveaway! #LipidTalks #Sphingolipids
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Herbert Tabor (1918 – 2020) asbmb.org/asbmb-today/people…

Herbert Tabor (1918 – 2020)

The longtime editor-in-chief of the Journal of Biological Chemistry was a beloved figure in the field.

asbmb.org
Fascinating interview with Jesse Roth, former Scientific Director for intramural @NIDDKgov. Developed the concept of receptors for insulin and other peptide hormones.
Journal of Clinical Investigation
@jclinicalinvest6 Jul 2020
.@UshmaNeill interviews Jesse Roth @NorthwellHealth in the latest episode of Conversations with Giants in Medicine: buff.ly/3e4vzm8 Full video interview: buff.ly/3gx8L09
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nature.com/articles/s41467-0…

Sphingolipids produced by gut bacteria enter host metabolic pathways impacting ceramide levels

Nature Communications - Ceramides are a type of sphingolipid (SL) that have been shown to play a role in several metabolic disorders. Here, the authors investigate the effect of SL-production by...

nature.com
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Inspiring story during a time of crisis. Kudos to Cyndi Tifft @IRPatNIH @NIHClinicalCntr #genetherapy Their three children have a fatal disease, and they refused to let the coronavirus take away their only chance at saving them washingtonpost.com/local/the…
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A mysterious blood-clotting complication is killing coronavirus patients washingtonpost.com/health/20…
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