The Greenberg lab investigates processes that affect genome integrity and how they influence human biology
The University of Pennsylvania, Philadel…
Joined October 2017
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Roger Greenberg retweeted
Congratulations to Zuzana Tothova, MD, PhD, recipient of our Postdoctoral and Graduate Student Association's Mentor-of-the-Year Award. Recognized for her rigorous yet compassionate approach, Dr. Tothova empowers trainees through thoughtful guidance, unwavering support, and a collaborative lab culture that helps young scientists grow with confidence, curiosity, and independence.
ALT Zuzana Tothova, MD, PhD, presented with the Postdoctoral and Graduate Student Association's Mentor-of-the-Year Award from Jose Cancelas, MD, PhD.
Roger Greenberg retweeted
I am excited to announce that the Marin Lab has just opened! We are based in the @Penn_CBIO at @PennMedicine at the University of Pennsylvania!
Roger Greenberg retweeted
I’m honored to have been named the next president & CEO of @TheWistar Institute.
I have long admired Wistar’s extraordinary science and collaborative culture and look forward to officially joining the Institute on Nov. 30.
bit.ly/4hvGZnd
Roger Greenberg retweeted
RESEARCH PAPER: rRNA 5′ETS processing contributes to nucleolar organization and nuclear architecture
By Mendoza-Figueroa et al. and Kathy Fange Liu
➡️ genesdev.cshlp.org/content/4…
@LiuFange @Penn @PennMedicine
#RNA #nucleus #genome
Roger Greenberg retweeted
Postdoctoral position available! Join us to investigate mechanisms of chromosome instability in human cells.
Roger Greenberg retweeted
We are saddened by the loss of G&D's long-time Editor, Terri Grodzicker.
When Terri stepped down as Editor in 2022, friends and colleagues wrote about her contributions to the research community. We are re-visiting these pieces, and thinking of her.
➡️ genesdev.cshlp.org/content/3…
Roger Greenberg retweeted
Congratulations to Vishva for all his groundbreaking discoveries !
An unexpected honor! Very humbling!
bignewsnetwork.com/news/2792…
Roger Greenberg retweeted
We’re hiring! 📣 Faculty positions are open at @CBE_Penn @PennEngineers @Penn this year. Apply now and join us! cbe.engineering.upenn.edu/ab…
Roger Greenberg retweeted
Mechanism of K63-linked polyubiquitin recognition and cleavage by the BRCA1-A complex dlvr.it/TTyPTd (RSS) #nature #MassSpecRSS
Roger Greenberg retweeted
New research out in @ScienceAdvances finds TRF2 couples muscle stem cell identity to regenerative repair ft. Ji-Hyung Lee, Foteini Mourkioti (@PennOrtho), Ryan Calhoun, Patrick Seale (@PennCDB/ @PennIDOM) & @RogerRogergr (@Penn_CBIO) @IRM_UPenn science.org/doi/10.1126/scia…
Roger Greenberg retweeted
New research out in @NatureComms finds that the BRCA1-A complex restricts replication fork reversal-dependent DNA repair in ATM deficient cells ft. @arindam_datta1, Yaroslav Morozov, Jinghan Qiu & @RogerRogergr (@Penn_CBIO) @PennGenomeInteg @BasserBRCA nature.com/articles/s41467-0…
Roger Greenberg retweeted
Meet Ralph Weichselbaum, MD, Chair of Radiation and Cellular Oncology and a leading radiation oncology expert. Follow him for insights on oligometastatic cancer, translational research and advances in cancer care. @rweichselbaum @UChicagoRadonc ow.ly/JBTY50ZjM95
Roger Greenberg retweeted
A $10M gift will accelerate the development of a new therapy aimed at treating retinal vasculopathy with cerebral leukoencephalopathy (RVCL), a rare genetic and fatal disease with no cure. @rvcl_research @miner_lab spr.ly/6013BEDbU9
Roger Greenberg retweeted
We're thrilled to announce PCGI Postdoc, Arindam Datta (Greenberg Lab), has published work showing that the BRCA1-A complex blocks replication fork reversal to restrict DNA end resection, defining the molecular basis of chemotherapy response in ATM-mutated cancers:
Congratulations to Arindam Datta @arindam_datta1 on publication of “The BRCA1-A complex restricts replication fork reversal-dependent DNA repair in ATM deficient cells”. nature.com/articles/s41467-0…
Congratulations to Arindam Datta @arindam_datta1 on publication of “The BRCA1-A complex restricts replication fork reversal-dependent DNA repair in ATM deficient cells”. nature.com/articles/s41467-0…
BRCA1-A enforces a restrictive chromatin state to suppress fork reversal in ATM deficient cells. This prevents genesis of resection substrates, implicating fork reversal as a key determinant of chemo-response in ATM deficient cells. Great collaboration with @vindigniLab
Roger Greenberg retweeted
Excited to share our review of molecular regulation/dysregulation of the cGAS/STING pathway. Kudos to co-authors Min-Guk Cho, Rachel Lee, and Jayce Johnson for leading this effort! @UNC_Lineberger @UNC_BCBP
Molecular mechanisms regulating cGAS-STING activation in health and disease: doi.org/10.1172/JCI204548
As part of the JCI’s Review Series on The cGAS-STING pathway: DNA sensing in health and disease, Min-Guk Cho et al. @UNC discuss how disruption or co-option of the processes governing cGAS/STING activation and regulation drive diverse diseases and highlight therapeutic strategies to restore immune balance.
#cGASSTING
Roger Greenberg retweeted
G&D's Editorial Board plays an important role in ensuring we publish cutting-edge research of the highest quality. We are pleased to welcome six new early-career investigators to our Editorial Board.
Learn more about the journal:
➡️ genesdev.cshlp.org/
Roger Greenberg retweeted
I am pleased to share the final piece of work from my time in the Wolberger Lab. Led by undergraduate Yash Bhargava, we performed a benchmark of AF3 on nucleosome-containing structures. Thank you to @CWolberger for allowing me to build this project up!
biorxiv.org/content/10.64898…
Roger Greenberg retweeted
Really exciting work from the #Binder/@DrORourke2 group @PennNSG + collaborators highlights how intracerebroventricular CAR-T doesn’t exert anti-tumor effects in isolation but is heavily influenced by the balance of specific cell populations in the CSF.
Remarkable correlative biology defining responders and non-responders to bivalent #GBM #CART cells from our group at @PennCancer @PennMedicine
@KitePharma
sciencedirect.com/science/ar…