Rotem Tal retweeted
Spatial analysis reveals the evolving organization of IDH-mutant glioma dlvr.it/TVbWMq
Rotem Tal retweeted
🧵1/ Happy to share our new study:
"Spatial analysis reveals the evolving organization of IDH-mutant glioma"
We asked: How is spatial organization established in glioma before the hypoxic architecture of advanced disease emerges?
cell.com/cancer-cell/fulltex…
ALT Graphical Abstract
Rotem Tal retweeted
Stoked to share our new paper w/ @TiroshLab in @NatureGenet! Using spatial multi-omics we characterized two distinct modes of p-EMT in HNSCC, each with their own distinct ecosystems and drivers. #SpatialTranscriptomics #HNSCC #Visium #CODEX #EMT
nature.com/articles/s41588-0…
Rotem Tal retweeted
ישראלים בחו״ל — בסוף אוקטובר יתקיימו בישראל עשרות כנסים אקדמיים. המועד המדויק (ככה"נ 19 או 26 באוק') ייקבע בקרוב
לרשימת עשרות הכנסים שמתארגנים: mind-il.org/
Rotem Tal retweeted
1/8 Thrilled to share that our new paper is officially out in @Nature today!
nature.com/articles/s41586-0…
Rotem Tal retweeted
Our #singlecell of pre/post-pembro HNSCC tumors is out in @CellRepMed! An MHCII/IFN program predicts ICI response pre-tx and likely reflects engagement between malignant cells/T-cells. Congrats to Michael Mints in @TiroshLab, @ReillyAlexS, and @Asp2145! cell.com/cell-reports-medici…
Rotem Tal retweeted
I'm thrilled to share that I'll be starting my lab (greenwald-lab.org) at the Lunenfeld-Tanenbaum Research Institute @SinaiHealth and joining @MoGen_Grad at the University of Toronto as an assistant professor this fall. 1/
Rotem Tal retweeted
1/ Truly excited to share our new study that I had to privilege to co-lead during my PhD alongside great friends and collaborators @M_Nomura, Kevin C. Johnson and Luciano Garofano, which was published @NatureGenet!
nature.com/articles/s41588-0…
Rotem Tal retweeted
1/ Thrilled to share our TWO back-to-back papers published in Nature Genetics today! nature.com/articles/s41588-0… , nature.com/articles/s41588-0…
Rotem Tal retweeted
New review about the clinical applications of scRNA-seq. Was a fun effort of the entire Tirosh Lab!
nature.com/articles/s41571-0…
Rotem Tal retweeted
In the Spotlight: A Material Transfer Agreement between #Glioblastoma and Normal Brain Cells aacrjournals.org/cancerdisco…
By Sajina Shakya, Christopher Hubert, and @JustinLathia
@CCLRI @caseccc @ClevelandClinic
Rotem Tal retweeted
Rare tumors make a difficult bedside to bench journey but quite on the contrary these unsolved mysteries remain and scream for help. We were blessed to lay our hands on a cohort of SiNETs & mixed lung NET & dissect their heterogeneity using scRNAseq. doi.org/10.7554/eLife.101153…
Rotem Tal retweeted
The @TiroshLab has another gem of a preprint.
The Curated Cancer Cell Atlas: comprehensive characterisation of tumours at single-cell resolution
biorxiv.org/content/10.1101/…
~125 datasets from across 40 cancer types, comprising ~2900 samples.
3CA website:
weizmann.ac.il/sites/3CA/
Rotem Tal retweeted
Excited to share our new paper out in @CD_AACR! We developed GCOs—glioblastoma cells grown in human cortical organoids—and used scRNA-seq to show their increased fidelity to patient cell states. Plus, we found tumor cells transfer malignant mRNAs to non-malignant cells!
Now online in @CD_AACR: #Glioblastoma-Cortical #Organoids Recapitulate Cell State Heterogeneity and Intercellular Transfer - by Vamsi Mangena, @RChanoch, Paola Arlotta, @tiroshlab, @MarioSuva, & colleagues doi.org/10.1158/2159-8290.CD… @broadinstitute @weizmannscience @MGHCancerCenter
Rotem Tal retweeted
Congrats to @MarioSuva lab, @TiroshLab, and @ArlottaLab, especially Vamsi and @RChanoch! A GBM cortical organoid model that not only recapitulates the core GBM cancer cell states, but also recapitulates intercellular communication between cancer cells and the TME via EVs! Having good model systems of intercellular communication will be great for functional studies. Really cool that this seems to be a more generalizable phenomenon (also observed in breast cancer cells engrafted in cortical organoids, mimicking brain mets) & very interesting as a model to further explore how cancer cells dynamically modulate their local environment.
Now online in @CD_AACR: #Glioblastoma-Cortical #Organoids Recapitulate Cell State Heterogeneity and Intercellular Transfer - by Vamsi Mangena, @RChanoch, Paola Arlotta, @tiroshlab, @MarioSuva, & colleagues doi.org/10.1158/2159-8290.CD… @broadinstitute @weizmannscience @MGHCancerCenter
Rotem Tal retweeted
🚨 New preprint alert! We performed scRNA-seq & scTCR meta-analysis on cancer patients treated with ICIs, revealing key T cell signatures linked to therapeutic response, with insights into clonal replacement vs reinvigoration! #scRNAseq #Immunotherapy
biorxiv.org/content/10.1101/…
Rotem Tal retweeted
💫NEW: Tamagawa, Fujii et al. show that squamous differentiation in human #PancreaticCancer can be attributed to TP63-mediated lineage conversion and epigenetic reprogramming that depends upon a hypoxic and #Wnt-defective niche.
👉🏾rdcu.be/dUBOs
nature.com/articles/s41556-0…
Rotem Tal retweeted
Checkout new paper from our lab in @NatureGenet link: nature.com/articles/s41588-0… We mapped pancreatic cancer ecosystems across primary tumors and metastases using spatial transcriptomics on matched samples . @2AteeqKhaliq @BasselElRayesMD @IUCancerCenter
Rotem Tal retweeted
I’m delighted to share our lab’s latest study now published @NatureGenet👉 tinyurl.com/2p97xpj8. Led by the fantastic duo @CarinaShiau #JingyiCao, and a big collaborative effort with @m_hemberg @davetingmgh @nanostringtech and others. 🧵
Rotem Tal retweeted
Nature research paper: A spatial expression atlas of the adult human proximal small intestine go.nature.com/3AiyMQ8