Student-run Twitter for the Rullo Lab @McMasterU, located in the Michael DeGroote Centre for Learning and Discovery (MDCL)🧪 Find us at: https://xitter.cf/t.co/ciUfezdULK

Joined July 2020
Happy to share some recent work in the lab developing covalent peptides to reprogram antibody targeting function bpspubs.onlinelibrary.wiley.…
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Incredibly proud of @RulloLab members Karolina Krygier, Tomas Frankovich and Anjalee Wijetunge for brilliant presentations at @qomsboc 2024!
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Replying to @LabRullo
@LabRullo was cited in an independent blog on @ScienceMagazine website written by Derek Lowe titled ā€œInduced Proximity in the Lab and in the Clinicā€. He is cited at the 4th link. šŸ”—science.org/content/blog-pos… Congratulations! šŸ‘šŸ„³ @RulloLab @machealthsci @MacDeptMed
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Restricted Rotational Flexibility of the C5α-Methyl-Substituted Carbapenem NA-1-157 Leads to Potent Inhibition of the GES-5 Carbapenemase dlvr.it/T4YBjx
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A beautifully written comprehensive review on the use of proximity induced chemistry to generate novel protein therapeutics by @Han_Xiao2016 cell.com/cell-chemical-biolo…
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Excited to present our work in covalent bifunctionals, for inducing cell-cell proximity in immunology ! #Covalent #proximity trccc.org/annual-meeting
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Excited to return to beautiful Boston this Tuesday and see great colleagues working in covalent drug development and proximity inducing molecules! covalent-drug-discovery.com/…
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Join us tomorrow for our Work in Progress Seminar! – at Hamilton, Ontario
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Join us tomorrow for WIP, featuring Annika Yardy from the Larche lab and Danielle Libera from the @jfekoenig @Jordana_Lab! – at Hamilton, Ontario
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A must read
Exploration of the Tunability of BRD4 Degradation by DCAF16 Trans-labelling Covalent Glues dlvr.it/SxGnd3
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Brilliant covalent chimeric technology developed by @ChoudharyLab to chemically modulate protein phosphorylation pubs.acs.org/doi/10.1021/acs…
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Proximity inducing molecules/ternary complexes are most often discussed in terms of protein degradation and PTMs. It’s worthwhile noting these are also extensively studied in immune engagement and have been for decades e.g @CarolynBertozzi /Bednarski pubs.acs.org/doi/pdf/10.1021…
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Closing up the morning poster session, we had fantastic 3MT from Zi Yang a MSc student from the @RulloLab, and Mei Nee Chu, a MSc student from the @DrMMukherjee lab! – at Hamilton, Ontario
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Online now! Chemoproteomics-enabled discovery of a covalent molecular glue degrader targeting NF-ĪŗB dlvr.it/Skd6vR #chembiol
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Profiling Sulfur(VI) Fluorides as Reactive Functionalities for Chemical Biology Tools and Expansion of the Ligandable Proteome dlvr.it/ShDqkz
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