@RulloLab

Student-run Twitter for the Rullo Lab @McMasterU, located in the Michael DeGroote Centre for Learning and Discovery (MDCL)🧪 Find us at: https://xitter.cf/t.co/ciUfezdULK

Joined July 2020
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  • Followers86
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Happy to share some recent work in the lab developing covalent peptides to reprogram antibody targeting function bpspubs.onlinelibrary.wiley.…
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Read it here: doi.org/10.1111/bph.70683

BPS Publications

LINKED ARTICLES This article is part of a themed issue Re-emergence of Covalent Modulation in Drug Discovery. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10....

bpspubs.onlinelibrary.wiley.com
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Exciting to see recent work from the Rullo Lab highlighted in this @BritPharmSoc editorial on the re-emergence of covalent modulation in drug discovery! 🧪 Great to see covalent chemistry continuing to expand what’s possible in chemical biology and immunotherapy.
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Very excited to share our group's latest research, published in @NatureComms, titled 'Mimicry of molecular glues using dual covalent chimeras'! @LabRullo Check out the full publication here: nature.com/articles/s41467-0…

Mimicry of molecular glues using dual covalent chimeras

Nature Communications - The authors report the development of dual covalent proximity inducing molecules capable of selectively cross-linking two non-interacting proteins. Through the selective...

nature.com
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Incredibly proud of @RulloLab members Karolina Krygier, Tomas Frankovich and Anjalee Wijetunge for brilliant presentations at @qomsboc 2024!
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Replying to @LabRullo
@LabRullo was cited in an independent blog on @ScienceMagazine website written by Derek Lowe titled “Induced Proximity in the Lab and in the Clinic”. He is cited at the 4th link. 🔗science.org/content/blog-pos… Congratulations! 👏🥳 @RulloLab @machealthsci @MacDeptMed
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Covalent bispecific molecules to engage tumor-immune proximity @LabRullo doi.org/10.1016/j.omton.2024…
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Brilliant contribution by @DASpiegel256 and co workers to induced proximity
J. Am. Chem. Soc.@J_A_C_S12 Jun 2024
Bifunctional Molecules That Induce Both Targeted Degradation and Transcytosis of Extracellular Proteins in Brain Cells | Journal of the American Chemical Society @Yale @YaleChem #Targeted #Degradation #Transcytosis #BrainCells #Proteins #Extracellular pubs.acs.org/doi/10.1021/jac…

Bifunctional Molecules That Induce Both Targeted Degradation and Transcytosis of Extracellular...

Abstract. Targeted protein degradation (TPD) has emerged as an effective therapeutic strategy for a wide range of diseases; however, the blood-brain barrie

pubs.acs.org
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Congratulations to Sandra for being named CDCR’s trainee of the month!
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Beautiful oxaziridine based oxidative approach to tryptophan labeling ! @christhechang and toste labs nature.com/articles/s41586-0…

Oxidative cyclization reagents reveal tryptophan cation–π interactions

Nature - Global profiling of hyper-reactive tryptophan sites across whole proteomes using tryptophan chemical ligation by cyclization (Trp-CLiC) reveals a systematic map of tryptophan residues that...

nature.com
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Restricted Rotational Flexibility of the C5α-Methyl-Substituted Carbapenem NA-1-157 Leads to Potent Inhibition of the GES-5 Carbapenemase dlvr.it/T4YBjx
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A beautifully written comprehensive review on the use of proximity induced chemistry to generate novel protein therapeutics by @Han_Xiao2016 cell.com/cell-chemical-biolo…
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Subunits of an E3 Ligase Complex as Degrons for Efficient Degradation of Cytosolic, Nuclear, and Membrane Proteins | ACS Synthetic Biology pubs.acs.org/doi/10.1021/acs…

Subunits of an E3 Ligase Complex as Degrons for Efficient Degradation of Cytosolic, Nuclear, and...

Abstract. Protein degradation is a highly regulated cellular process crucial to enable the high dynamic range of the response to external and internal stim

pubs.acs.org
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Excited to present our work in covalent bifunctionals, for inducing cell-cell proximity in immunology ! #Covalent #proximity trccc.org/annual-meeting

Annual Meeting | TRCCC

trccc.org
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Excited to return to beautiful Boston this Tuesday and see great colleagues working in covalent drug development and proximity inducing molecules! covalent-drug-discovery.com/…
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Join us tomorrow for our Work in Progress Seminar! – at Hamilton, Ontario
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Check out our newest publication featuring @BenjaminLake15 ! Congratulations!
Anthony Rullo: chemically modulating proximity@LabRullo3 Nov 2023
Happy to share our most recent contribution coupling covalency with carbohydrate binding for immune proximity induction. pubs.acs.org/doi/full/10.102…

Offsetting Low-Affinity Carbohydrate Binding with Covalency to Engage Sugar-Specific Proteins for...

Abstract. Carbohydrate-binding receptors are often used by the innate immune system to potentiate inflammation, target endocytosis/destruction, and adaptiv

pubs.acs.org
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Join us tomorrow for WIP, featuring Annika Yardy from the Larche lab and Danielle Libera from the @jfekoenig @Jordana_Lab! – at Hamilton, Ontario
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A must read
Covalent Modifiers@CovalentMod11 Oct 2023
Exploration of the Tunability of BRD4 Degradation by DCAF16 Trans-labelling Covalent Glues dlvr.it/SxGnd3
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⁦Beautiful review ⁦@Han_Xiao2016⁩ ! pdf.sciencedirectassets.com/…
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