MITOGUARDER Co-Lead | Postdoc @helsinkiuni | Protein biogenesis, chemical biology, drug discovery | Foodie, coffee lover, penguin enthusiast.
Helsinki, Suomi
Joined January 2021
- Tweets120
- Following332
- Followers178
- Likes417
Sarah O'Keefe retweeted
My new group at @Physics_TAU @TampereUni has an open postdoc position!
Retweets and distribution by other means are highly appreciated☺️
tuni.rekrytointi.com/paikat/…
Sarah O'Keefe retweeted
Structurally intriguing metallophores. Huge congratulations to a phenomenal, international team led by first authors @NicoleEAvalon @mar_reis_ Chris Thornburg. What a privilege to be a part of this 25-year story | JACS pubs.acs.org/doi/10.1021/jac…
Sarah O'Keefe retweeted
Absolutely shocked and incredibly honoured to have been awarded this prize!!
HUGE thank you to @The_MRC for this amazing recognition, and @ExDrosoScientia+@rachelcowen for being there on my behalf ❤️ we have funding for legacy planning now! Go postdocs! #LovePostdocs @UK_NPAW
Sarah O'Keefe retweeted
Sooo excited to represent the amazing @tranejoan at the #mrcimpactaward 🥳 Soooooo very much deserved! Joan is a true trailblazer & champion for postdocs and research culture! Also very excited that the importance of supporting postdocs is recognised! #npaw2024 will be epic!!
Absolutely shocked and incredibly honoured to have been awarded this prize!!
HUGE thank you to @The_MRC for this amazing recognition, and @ExDrosoScientia+@rachelcowen for being there on my behalf ❤️ we have funding for legacy planning now! Go postdocs! #LovePostdocs @UK_NPAW
Sarah O'Keefe retweeted
Out of the gate: @mitoguarder. A joint innovation biotech with Co-lead @SOKeefe91. Check out our tech at mitoguarder.com and follow us.
Sarah O'Keefe retweeted
We still have open PhD positions here in our cryo-EM group @ZmbhH @UniHeidelberg.
Please apply via the Heidelberg Biosciences International Graduate School or directly send us your application documents.
hbigs.uni-heidelberg.de/
We have two open PhD positions to explore structures of ribosomes and gamma-tubulin complexes using cryo-EM approaches here in our group @ZmbhH @UniHeidelberg.
Please apply via the Heidelberg Biosciences International Graduate School @HBIGS_HD: hbigs.uni-heidelberg.de/
Sarah O'Keefe retweeted
Please check out out our paper with @CBJacksonLab and @Solocanuck👇
Supernumerary proteins of the human mitochondrial ribosomal small subunit are integral for assembly and translation cell.com/iscience/fulltext/S…
@GMonteuuis @KrysiaBroda @ElizabethPyman @_DiegoBalboa_ 1/7
Sarah O'Keefe retweeted
We have optimized a human in-vitro translation system (HITS) for use in #ribosome research
Our HITS:
🧪requires a minimal number of components
💵is cheap & easy to prepare
💡enables cap-dependent translation
📈is highly active
online now: bit.ly/49xTdVa
@CellRepMethods
Sarah O'Keefe retweeted
Hey everyone - Pls RT - we’ve got a great position open for a talented #postdoc scientist to join us @HiLIFE_helsinki @helsinkiuni to study the spatial organization of #metabolism in #intestinal #stem cells and #cancer! Interested? Just get in touch. Apply by the 4th of May aka Star Wars Day 😃
nature.com/naturecareers/job…
Sarah O'Keefe retweeted
We are happy and proud to present a molecular movie of our current understanding of co-translational protein processing and ER targeting in mammalian cells, summarising decade-long research.
Subscribe for updates!
youtube.com/watch?v=yUFwGThu…
Sarah O'Keefe retweeted
🔬 Exciting News! Join us for #TieteidenYö - The Night of Science 2024 on Jan 25th, 18:00-19:40 at CoolHead Brewery. ViPA presents a special event featuring postdoc researchers for individuals interested in scientific topics. Free admission! @helsinkiuni #ViiKKi @tieteidenyo
Sarah O'Keefe retweeted
I'm happy if somewhat shy to share my review on protein PTMs: the history of PTM research, key paradigms, chemical & mechanistic principles, and hypotheses re PTM evolution. I thought a unified narrative like this might be interesting to some readers. onlinelibrary.wiley.com/doi/…
Sarah O'Keefe retweeted
@SOKeefe91 and I are recruiting postdocs for an exciting project funded by @BusinessFinland. Come join us at the Institute of Biotechnology @BIOTECH_UH , HiLIFE @HiLIFE_helsinki , University of Helsinki @helsinkiuni . Please retweet/repost. Apply here: nature.com/naturecareers/job…
📢 Calling all #postdocs 📢 We are recruiting! Join our science team at @helsinkiuni to bring our enhanced recombinant protein technology to market. Apply now for a unique research role in science innovation, start-up formation & business development👇nature.com/naturecareers/job…
Sarah O'Keefe retweeted
Check out our new preprint on lipid scrambling by the Sec61/TRAP complex utilising #martini3, also involving @DenysBiriukov from @CEITEC_Brno. The next step is to get this experimentally tested🤞
These findings are reported in our new preprint , although physiological relevance of lipid scrambling by Sec61/TRAP remains to be explored.
biorxiv.org/content/10.1101/…
Sarah O'Keefe retweeted
Happy to report our new structure of Sec61 and the TRAP complex out now in @emboreports! This has been a nice group effort with us @BIOTECH_UH and with @JuhaHuiskonen and @LHapponen @lunduniversity.
embopress.org/doi/full/10.15…
Sarah O'Keefe retweeted
Our article "Visible Light Activates Coumarin-Caged mRNA for Cytoplasmic Cap Methylation in Cells" was accepted in Chemistry😊We can now photocage and release the mRNA 5' cap at the N7G . Kudos to Amarnath Bollu & Helena Schepers 👏 chemistry-europe.onlinelibra…
Sarah O'Keefe retweeted
New paper: The SARS-CoV-2 protein ORF3c is a mitochondrial modulator of innate immunity
cell.com/iscience/fulltext/S…
Delighted to have contributed to this work, led by Hazel Stewart from the @FirthLab, and Yongxu Lu!
Sarah O'Keefe retweeted
Exciting #PhD opportunity at @helsinkiuni! We're seeking a dedicated Doctoral Researcher in Molecular and Structural Biology. Dive into cutting-edge research in a collaborative environment. Learn more & apply: bit.ly/PhDUH #AcademicTwitter #PhDChat #SciJobs
Sarah O'Keefe retweeted
In the final manuscript submitted before summer holidays, we check how well the different all-atom force fields capture the effects of cholesterol on phosphatidylcholine bilayers.
chemrxiv.org/engage/chemrxiv…
Sarah O'Keefe retweeted
I am happy to propose a model for mammalian #mitochondria UPR signaling, published @Nature.
nature.com/articles/s41586-0…
Mito protein misfolding induces two cytosolic signals –mtROS and mito protein precursor accumulation. These activate the mito UPR via a DNAJA1-HSF1 signaling axis.
