PhD | Endothelial dysfunction in vascular disease @UHN • MD Student @UofTMedicine • 🐱☕🚴🏋️🇨🇦
Toronto, Ontario
Joined May 2019
- Tweets255
- Following502
- Followers419
- Likes2.3K
Steven Botts retweeted
👏Congratulations to Dr. Giuseppe Papia on being named president-elect of the Canadian Society for Vascular Surgery (CSVS); a tremendous honour reflecting the respect & confidence of the national vascular surgery community. His term as president will begin in Oct 2027.
ALT Dr. Giuseppe Papia named president-elect of the Canadian Society for Vascular Surgery (CSVS)
Steven Botts retweeted
(1/2) Congratulations to Drs. Mamatha Bhat and @kat_howe, inaugural recipients of the SUMO–UHN Distinguished Physician Investigator Award. 🎉
🔗 Read more: uhnresearch.ca/news/10-02-20…
ALT Portraits of two smiling female researchers with institutional logos and text.
Steven Botts retweeted
New research from @UHN’s @PMunkCardiacCtr shows that the protein ERG helps protect blood vessels from changes that drive atherosclerosis—the buildup of plaque in the arteries. Findings could point to future therapeutic strategies to protect arteries.
🔗: uhnresearch.ca/news/9-04-202…
ALT Illustration of a heart beside a cross-section of an artery narrowed by plaque buildup, with red blood cells flowing through the vessel, depicting cardiovascular disease.
Steven Botts retweeted
Reposting - our new story - now available for all! Open access. nature.com/articles/s41467-0… Thank you @NatureComms for the incredible editorial work and review process. Hard work that led to a transformative paper! Congrats team @SRBotts @kat_howe @FishLab_UHN
#EndothelialDysfunction is a critical driver of #atherosclerosis, but how can EC identity be preserved to limit plaque progression?
Thrilled to share my final PhD work in @NatureComms: bit.ly/4fxmpl7
@kat_howe @FishLab_UHN @PMunkCardiacCtr @UHN_Research @UofTVascular
Steven Botts retweeted
A new study in @NatureComms, led by @UHN collaborators including Drs. @kat_howe and Jason Fish investigate the role of the ETS transcription factor ERG, a key regulator of #endothelial identity, in atheroprogression. 🧫 go.nature.com/4pzZB7Z
They identify ERG as an enforcer of endothelial function that restricts 🚫 endothelial‑to‑mesenchymal transition to limit atherosclerosis.
Steven Botts retweeted
This football match is like watching somebody tweak their UMAP hyperparameters for 90 minutes on twitch.
Steven Botts retweeted
Congrats to @SRBotts, @kat_howe & @FishLab_UHN labs at @UHN for this work. The importance of #endothelial health/identity in #atherosclerosis cannot be understated! ERG dysregulation in #cardiovascular health in #rodents and translated to #human #aortic disease.
#EndothelialDysfunction is a critical driver of #atherosclerosis, but how can EC identity be preserved to limit plaque progression?
Thrilled to share my final PhD work in @NatureComms: bit.ly/4fxmpl7
@kat_howe @FishLab_UHN @PMunkCardiacCtr @UHN_Research @UofTVascular
Steven Botts retweeted
Congrats!!👏🏼 Massive tour de force by an amazing team. See this incredible work 🙏
#EndothelialDysfunction is a critical driver of #atherosclerosis, but how can EC identity be preserved to limit plaque progression?
Thrilled to share my final PhD work in @NatureComms: bit.ly/4fxmpl7
@kat_howe @FishLab_UHN @PMunkCardiacCtr @UHN_Research @UofTVascular
Steven Botts retweeted
The aorta doesn't get enough respect. Even though it's uncommon, in someone who presents with chest pain, especially severe, we were trained to rule out aortic dissection before anything else.
Most likely Senator Graham had a Type A dissection and longstanding hypertension. If obtained previously, an echocardiogram or other image may have revealed a widening or aneurysm of the thoracic aorta.
nature.com/articles/nrdp2016…
Steven Botts retweeted
Getting a cholesterol screening is a lot less complicated than memorizing all of Scorpion’s finishers. Just call your doctor and ask for a simple blood test.
#MortalKombatMovie #MortalKombat
Steven Botts retweeted
New paper by @SRBotts !! Congratulations 👏👏
Read it here: link.springer.com/article/10…
Steven Botts retweeted
Congratulations to this stellar team! Thank you Kristen, Steve and Kai. @SRBotts - wonderful thread to share the news with clarity. @FishLab_UHN and @kat_howe - we LOVE this work. 🙏support from @UHN_Surgery @UHN_Research @PMunkCardiacCtr @UofT @CIHR_IRSC
Very excited to share chapter 1 of our endothelial identity story out now in @GenomeMedicine !!
Here we show that ERG governs dynamic and reversible EndMT in arterial ECs to limit endothelial dysfunction: link.springer.com/article/10…
@FishLab_UHN @kat_howe @Kristen_ESchulz
Steven Botts retweeted
2026 Vascular Research Initiatives Conference (VRIC) vascular.org/vascular-specia… REMINDER! Theme entitled Metabolomica - check the site and register. Vascular surgeon-scientist conference for basic and translational researchers! @VascularSVS @AHAScience
Steven Botts retweeted
Very excited about this study in @EmboMolMed, where we show that KRAS mutations drive glycolytic reprogramming of the endothelium in sporadic brain arteriovenous malformations. We show a synergistic impact of targeting glycolysis and MEK. link.springer.com/article/10…
Steven Botts retweeted
Dr. @MattSmeds walks in the Vascular Health Step Challenge to raise awareness for PAD and the modifiable risk factors that can lesson pain for patients. He encourages you to do the same!
📲 Sign up & start walking today! ow.ly/WYqR50WNJ9Z
#StepWithSVS #PADAwarenessMonth
Steven Botts retweeted
Excited to announce my latest publication as the lead author, featuring the cover image! Impairment of stromal-epithelial regenerative cross-talk in Hirschsprung disease primes for the progression to enterocolitis | Science Translational Medicine science.org/doi/10.1126/scit…
Steven Botts retweeted
Incredible work from Dr. Kathryn Howe and the @PMunkCardiacCtr team. Advancing our understanding of vascular biology is essential to improving care and preventing heart disease.
The buildup of cholesterol and inflammation in artery walls is a leading cause of heart disease.
Researchers at UHN led by Dr. Kathryn Howe @PMunkCardiacCtr are studying how the cells lining blood vessels communicate and drive this process.
Read more: bit.ly/44Jt9XV
Steven Botts retweeted
Our first grad spotlight: congrats @BaharBehrouzi !! Wishing you all the best in residency @McMasterGIM 😀
Steven Botts retweeted
@MandyKZGuo et al found that endothelial cell communication can be tracked in #atherosclerosis. Endothelial-derived #EVs can be detected within #macrophages deep within plaques ahajrnls.org/43H7vSc
@kat_howe @FishLab_UHN @CoreyScipione @SnehaRajuMD @SRBotts @sarv_PhD
