Wansang Cho (@ScienceWansang) profile picture

Wansang Cho

@ScienceWansang

Postdoc @Stanford Immune cell engineering in @ScienceKyle Lab. BS/PhD @SeoulNatlUni Chemical biology/drug discovery. Build better immunotherapy.

Joined September 2023
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  • Following140
  • Followers34
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Photo by Wansang Cho (@ScienceWansang)
Wansang Cho retweeted
Jonathan Kagan (@jkagan1) profile picture
Jonathan Kagan@jkagan13h
The NRF2-KEAP1 regulon is a transcriptional checkpoint for the NLRP3 inflammasome. Very pleased to share our study on how NRF2-KEAP1 links extracellular matrix sensing to NLRP3 regulation. Links to fibrosis, inflammation and cancer are presented. nature.com/articles/s41586-0…
NRF2 is a mechanosensitive checkpoint for NLRP3 inflammasome activation

NRF2 is a mechanosensitive checkpoint for NLRP3 inflammasome activation

Nature - The stiffness of the extracellular matrix is identified as a pivotal factor that influences activation of the NLRP3 inflammasome in vitro and in vivo.

nature.com
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Wansang Cho retweeted
Jonathan Kagan (@jkagan1) profile picture
Jonathan Kagan@jkagan1Sep 23
Today, the Toll-like Receptors reveal a new mechanism of signal transduction: Receptor-Free Signal Transduction. nature.com/articles/s41586-0…
TRAM promotes Toll-like-receptor-free myddosome signal transduction

TRAM promotes Toll-like-receptor-free myddosome signal transduction

Nature - TRAM is a regulator of myddosome assembly through dissociating MyD88 from the TLR–TIRAP complex to enable myddosome maturation and durable downstream signal transduction.

nature.com
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Wansang Cho retweeted
Waggoner Lab (@LabWaggoner) profile picture
Waggoner Lab@LabWaggonerOct 28
Brain-sensing synNotch–CAR T cells exhibit efficacy against preclinical models of diffuse midline glioma, outperforming conventional CAR T cells science.org/doi/10.1126/scit… @ScienceTM @UCSF
Image from Waggoner Lab (@LabWaggoner)
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Wansang Cho retweeted
Klebanoff_Lab (@KlebanoffLab) profile picture
Klebanoff_Lab@KlebanoffLabOct 27
🚨New collaborative paper with @KathyHsuLab. We show that NKG2C+CD8+ TKLR cells can be TCR/CAR-engineered to deliver potent antitumor activity with ⬆️persistence, ⬇️ exhaustion, and ⬇️CRS potential. @MSKCancerCenter @MSK_DeptOfMed @parkerici @JCI_org jci.org/articles/view/193053
Image from Klebanoff_Lab (@KlebanoffLab)
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Wansang Cho retweeted
Waggoner Lab (@LabWaggoner) profile picture
Waggoner Lab@LabWaggonerOct 10
Spatiotemporal co-regulation of IL2 and TCR receptors reveals early antigen-driven synaptic synergy in human CD8+ T cells @NatureComms @CueBiopharma @MichaelLDustin @UniofOxford nature.com/articles/s41467-0…
Image from Waggoner Lab (@LabWaggoner)
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Wansang Cho retweeted
Peter Du (@peterdu_) profile picture
Peter Du@peterdu_Sep 19
CRISPR screens are great at telling you what a gene is doing inside your cells. But what if you're interested in what's happening to its neighbors? Today, I'm excited to share match-seq, a new method that deciphers cell-cell interactions using barcoded RNA transfer. 1/9
Image from Peter Du (@peterdu_)
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Wansang Cho retweeted
Heczey Lab (@HeczeyLab) profile picture
Heczey Lab@HeczeyLabSep 10
Complete Regression of Hepatoblastoma after Interleukin-15– and Interleukin-21–Coexpressing CAR T-Cell Therapy | New England Journal of Medicine nejm.org/doi/full/10.1056/NE… @seattlechildren @TexasChildrens @NIH
Complete Regression of Hepatoblastoma after Interleukin-15– and Interleukin-21–Coexpressing CAR...

Complete Regression of Hepatoblastoma after Interleukin-15– and Interleukin-21–Coexpressing CAR...

A 3-year-old boy with chemotherapy-resistant metastatic hepatoblastoma had complete regression lasting at least 12 months after two infusions of glypican-3–specific CAR T cells coexpressing interle...

nejm.org
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Thoughts on CAR-T autoimmune deaths: a) Type of autoimmune dz likely matters, given underlying tissue pathology -> potential for adverse events (ex: vasculitis vs rheum). b) Polygenic factors cause autoimmunity, which could influence CAR-T phenotype, area needs to be explored
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Excited to share our new preprint! We asked how inducible SynNotch-CAR circuits can better discriminate on-target from off-target cells when they share similar antigens. biorxiv.org/content/10.64898… Congratulations to Daniel Hoces, Jaclyn Ng and Julian Perez!
Image from Rogelio Hernández-López (@RogelioHdezL)
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Wansang Cho retweeted
nature (@Nature) profile picture
nature
@NatureAug 31
Nature research paper: A binding-to-release strategy for targeted anticancer drug delivery go.nature.com/46l6Bg2
A binding-to-release strategy for targeted anticancer drug delivery

A binding-to-release strategy for targeted anticancer drug delivery

Nature - A binding-to-release drug conjugate strategy enables targeted payload release without cellular internalization, improving tumour specificity, efficacy and expanding therapeutic targets...

nature.com
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Wansang Cho retweeted
Waggoner Lab (@LabWaggoner) profile picture
Waggoner Lab@LabWaggonerAug 29
Antibody Fc receptor CD16a mediates NK cell activation via mechanotransduction of piconewton forces @Stanford @ScienceAdvances science.org/doi/10.1126/scia…
Image from Waggoner Lab (@LabWaggoner)
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Waggoner Lab (@LabWaggoner) profile picture
Waggoner Lab@LabWaggonerAug 22
Enhanced antitumor immunity of mRNA vaccines by bioorthogonal-like delayed activation of exogeneous STING @NatureBiotech 🇨🇳 nature.com/articles/s41587-0…
Image from Waggoner Lab (@LabWaggoner)
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Julia Carnevale (@jccarnevale) profile picture
Julia Carnevale
@jccarnevaleAug 17
Another major milestone for my lab - our second paper is out today in Nature Biotechnology! Co-led by @pascal_devant & @HyuncheolJung, with Alex Marson: nature.com/articles/s41587-0…
Virus-like particles enable targeted gene engineering and pooled CRISPR screening in primary human...

Virus-like particles enable targeted gene engineering and pooled CRISPR screening in primary human...

Nature Biotechnology - Primary human myeloid cells are efficiently edited using virus-like particles.

nature.com
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this is pretty cool: nature.com/articles/s41592-0…
Design and optimization of a kinase-controlled allosteric switch

Design and optimization of a kinase-controlled allosteric switch

Nature Methods - This Article introduces a phospho-switch for allosterically regulating target proteins in response to ERK kinase activity.

nature.com
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Published this week @NatureMedicine, B7-H3 CAR T cells show promise in patients with rGBM! Congrats to all authors for another big step forward for our field. nature.com/articles/s41591-0…
Image from Bryan D. Choi MD PhD (@BryanDChoi)
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Wansang Cho retweeted
AACR (@AACR) profile picture
AACR
@AACRAug 6
ICYMI: On the #AACRBlog— Read about three studies from #AACRio26 that leverage innovative science to give the immune system a better chance against cancer. brnw.ch/21x4JoA @idibaps @Stanford @MIT @ScienceWansang @MegTriesScience
Image from AACR (@AACR)
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Wansang Cho retweeted
Justin Eyquem (@j_eyquem) profile picture
Justin Eyquem@j_eyquemJul 29
Exciting collaboration with the Benoist lab! Using our mouse T cell engineering system that enables TCR replacement, we explored the roles of TCR/Antigen pairs in programing peripheral Treg ! cell.com/immunity/fulltext/S…
TCR origin and specificity to environmental or self-antigens on distinct antigen-presenting cells...

TCR origin and specificity to environmental or self-antigens on distinct antigen-presenting cells...

Using CRISPR-based TCR editing, Chi et al. systematically compare gut TCRs recognizing dietary, microbial, and self-antigens to define the principles that govern peripheral Treg cell differentiation....

cell.com
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Wansang Cho retweeted
Bhardwaj Lab (@BhardwajLab) profile picture
Bhardwaj Lab@BhardwajLabJun 10
Check out our latest review👏! We dive deep into how cDC1s orchestrate anti-tumor immunity through cross-presentation, immune networking, and spatial organization.
Journal of Experimental Medicine (@JExpMed) profile pictureJournal of Experimental Medicine@JExpMedJun 10
Ward, Kar, Balan, and Bhardwaj @BhardwajLab review how conventional type 1 #DendriticCells (cDC1s) coordinate antitumor immunity through cross-presentation, immune cell networking, and spatial organization in tumors. hubs.la/Q04kVmqr0 #CancerFocus #Immunotherapy
Image from Journal of Experimental Medicine (@JExpMed)
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Online now: Taxane chemotherapy promotes response to TIM-3 checkpoint blockade via STING-mediated ER stress and HMGB1 secretion dlvr.it/TSpzvr
Taxane chemotherapy promotes response to TIM-3 checkpoint blockade via STING-mediated ER stress and...

Taxane chemotherapy promotes response to TIM-3 checkpoint blockade via STING-mediated ER stress and...

Onimus et al. find that select cytotoxic therapies induce active HMGB1 secretion and show combinatorial efficacy with anti-TIM-3 antibodies. Taxanes specifically promoted HMGB1 release via TLR4-dri...

cell.com
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Wansang Cho retweeted
Jalal (@Jalal_Ahmed) profile picture
Jalal
@Jalal_AhmedMay 22
Thrilled to share our new paper out today in @NatureCancer: Tumor irradiation promotes antigen dressing of dendritic cells to enhance CAR T cell persistence and efficacy in lung metastases. A single dose of radiotherapy makes CAR T cells work against extensive metastatic lung cancer — even when the target antigen is also on normal tissues. nature.com/articles/s43018-0… 🧵 (1/14)
Tumor irradiation promotes antigen dressing of dendritic cells to enhance CAR T cell persistence...

Tumor irradiation promotes antigen dressing of dendritic cells to enhance CAR T cell persistence...

Nature Cancer - Ahmed and colleagues show that, by promoting ‘dressing’ of intact tumor target antigens onto dendritic cells, tumor irradiation enhances chimeric antigen receptor T cell...

nature.com
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