SebNielsen (@SebNielsen77) profile picture

SebNielsen

@SebNielsen77
Joined August 2017
  • Tweets27
  • Following127
  • Followers30
Very excited to have contributed to the latest publication from the Brown Lab. We have developed an approach for spatial genomics called Perturb-map that enables functional genomics at single-cell resolution with the spatial architecture preserved authors.elsevier.com/c/1eknl…
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We’re looking for a postdoc to join our team and investigate early detection markers in pancreatic cancer ⏰Apply by 13th March! More details here: beatson.gla.ac.uk/Postdoctor… #postdocjobs
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Delighted to share our latest work @Brown_lab1, developing Perturb-map: a platform enabling CRISPR genomics with spatial resolution in tissue sections @SinaiImmunol @IcahnInstitute @SinaiGenetics biorxiv.org/content/10.1101/… A thread!👇(1/12)
Perturb-map enables CRISPR genomics with spatial resolution and identifies regulators of tumor...

Perturb-map enables CRISPR genomics with spatial resolution and identifies regulators of tumor...

The cellular architecture of a tumor, particularly immune composition, has a major impact on cancer outcome, and thus there is an interest in identifying genes that control the tumor microenvironment...

biorxiv.org
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SebNielsen retweeted
ErlerLab (@ErlerLab) profile picture
ErlerLab@ErlerLab2 Jul 2021
Check out our latest work, that highlights the importance of the #ECM in pre-clinical studies. #breastcancer #metastasis @edrhorton @AdinaJensen3 @RaphaelReuten @UCPH_BRIC @ERC_Research # mdpi.com/1174966 ##mdpicancers via @Cancers_MDPI
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SebNielsen retweeted
ErlerLab (@ErlerLab) profile picture
ErlerLab@ErlerLab7 Jun 2021
We are thrilled to share with you our latest research, showing how lorlatinib suppresses tumour associated neutrophils in pancreatic cancer! Congratulations @SebNielsen77 @JanStrbech1 and the rest of the Erler lab! rdcu.be/cl4Dc
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I am excited to share that our research was published today in @NatureComms. Thanks to all members of @ErlerLab and all our collaborators for making it possible! Check it out using this link: rdcu.be/cl4hK
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Great honour for our article (nature.com/articles/s41563-0…) to get a N&V @NatureMaterials nature.com/articles/s41563-0… Many thanks to @NatureMaterials, Patrick Mehlen & Laurent Fattet @Matrixbiologie @IntSocMatBio @amsocmatbio @MBIreland @MatrixBioANZ @DFG_FOR2722 @CIBSS_UniFR @UCPH_BRIC
Image from Raphael Reuten (@RaphaelReuten)
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Congratulations to the Fantastic Brian Brown @SinaiImmunol @TischCancer for another Innovative awards to develop a super cool novel CAR-T strategy directed against the immune micro-environment to enhance tumor immunity. Bravo Brian
Alliance for Cancer Gene Therapy (@ACGTFoundation) profile pictureAlliance for Cancer Gene Therapy@ACGTFoundation1 Mar 2021
Excited to support the work of Brian Brown, PhD, at @IcahnMountSinai, who is receiving a $500,000 grant to further the work of a promising immunotherapy approach to fight lung cancer and other solid tumors. bit.ly/3r7xFZQ via @EurekAlert #lungcancer #immunotherapy
Image from Alliance for Cancer Gene Therapy (@ACGTFoundation)
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Our review "Determinants, mechanisms, and outcomes of myeloid cell diversity in cancer" is out! We tried to rationalize the complex interplay bw #tumors, #macrophages/#neutrophils under the lens of #genomics #scrnaseq. Hope you enjoy, feedbacks welcome! onlinelibrary.wiley.com/doi/…
Determinants, mechanisms, and functional outcomes of myeloid cell diversity in cancer

Determinants, mechanisms, and functional outcomes of myeloid cell diversity in cancer

Most, if not all, aspects of carcinogenesis are influenced by the tumor microenvironment (TME), a complex architecture of cells, matrix components, soluble signals, and their dynamic interactions in...

onlinelibrary.wiley.com
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SebNielsen retweeted
ErlerLab (@ErlerLab) profile picture
ErlerLab@ErlerLab25 Jan 2021
Our latest research just out @NatureMaterials We identify that basement membrane stiffness is regulated by Netrin-4 levels and is critical for metastatic spread in multiple cancer types! Congratulations @RaphaelReuten, co-authors and collaborators 👉 nature.com/articles/s41563-0…
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We are pleased to announce that Neutrophil 2021 is happening online. See announcement ⬇️ #Neutrophil2021 "zoomed in" 31 May - 1 June 21, RT & follow for further announcements
Image from Neutrophil2021 (@neutrophil2021)
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nature (@Nature) profile picture
nature
@Nature7 Oct 2020
“People looking at the evidence are understanding it differently. It’s legitimately confusing.” go.nature.com/3loC1Zy
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Additional restrictions today on H1B visa applications based on the false narrative that H1B visa holders hurt american economy. Yet several articles including ours doi.org/10.1016/j.cell.2020.… have explained why this is not the case dhs.gov/news/2020/10/06/depa…
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Read about the current state of pancreatic immuno-oncology, ongoing trials to keep an eye on, and what I (humbly) think lies ahead for this challenging disease. My succint review published with @SpringerNature in IJSO. rdcu.be/b6sgf
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Dear Scientists - We started a petition (link below) with @vilcek to oppose this administration's ban on non-immigrant work visas and on international students attending online-only schools. #StopTheVisaBan #ImmigrantScience. (1/2) docs.google.com/forms/d/e/1F…
New Visa Policies Harm America’s Interests

New Visa Policies Harm America’s Interests

As current and former heads of leading American biomedical research laboratories and trainees in those laboratories, we strongly oppose the proclamation signed by President Trump suspending entry to...

docs.google.com
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I am very excited about this opportunity! Thank you to the @novonordiskfond for funding the project! novonordiskfonden.dk/en/news…
Fellowships enable talented researchers to work at leading research institutions abroad - Novo...

Fellowships enable talented researchers to work at leading research institutions abroad - Novo...

novonordiskfonden.dk
SebNielsen retweeted
ErlerLab (@ErlerLab) profile picture
ErlerLab@ErlerLab12 Feb 2020
Review from @mrafaeva is now online @FEBSJournal: Framing cancer progression: influence of the organ‐ and tumour‐specific matrisome febs.onlinelibrary.wiley.com…
Image from ErlerLab (@ErlerLab)
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Pancreatic cancer survival rates in double digits for the first time, but still a lot of improvements to be made! pancan.org/news/pancreatic-c…
New p53 mutant mouse model of pancreatic cancer in @jclinicalinvest insight.jci.org/articles/vie…
Exciting stuff! Detailed profiling of the ECM in the metastatic microenvironment published in Cancer Discovery @AACR sm.aacr.org/Sv0f30gX3EB
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