@SiddhuLab

Assistant Professor at #PCC @WUR | Soft Matter, Biophysics, Synthetic Biology, Microfluidics | Father of two lovely Homo sapiens

 Wageningen, The Netherlands
siddharthdeshpandelab.com
Joined January 2018
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Our actinosome story is now online in @ACSSynBio pubs.acs.org/doi/10.1021/acs… Look at these cuties express GFP in a flash! Excellent work by the first author @ketanganar; worth mentioning that the idea was sparked serendipitously with a BSc student doing a thesis with us 😀 @PCC_WUR
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A three-dimensional container capable of orchestrating biochemical reactions is a prerequisite for engineering #synthetic #cells Researchers at Wageningen University have developed a simple technique for making them. syntheticcell.eu/2022/11/14/… @SiddhuLab @ketanganar
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Very happy to contribute to '3D-printed PDMS barriers for flexible flow control in paper microfluidics', now published in @ACS_AMI pubs.acs.org/doi/abs/10.1021… Congrats to the team and Chang Chen, currently doing a PhD with us! blue 0 barriers fast flow, red 6 barriers slow flow
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Our work on liquid crystals as biosensors is now online in @ACS_AMI! Look at these beauties rapidly switch their colour in response to amphiphiles. We show lipid and fatty acid sensing both in vitro and in live zebrafish! pubs.acs.org/doi/10.1021/acs… Great work by @lwhonaker @PCC_WUR
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And of course I should not forget @sylvia_brugman who added further excitement to the story through zebrafish experiments!
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See below for a nice postdoc opportunity to do interdisciplinary research involving micro(scopy + fluidics + biome)!
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Siddharth Deshpande retweeted
JCBLab 🇺🇦🕊@BaretJc29 Mar 2022
Open Post-doc position in our group in Bordeaux ! Physical Assembly of Life-like systems Apply here: bit.ly/3BvrHrL #Emploi via @EmploiCnrs @SynCellEU @MaxSynBio @univbordeaux @CNRSAquitaine @BxFrontiers
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We have a postdoc position available, on the exciting topic of condensates and phase separation! Great opportunity to work at @PCC_WUR and the beautiful green campus of Wageningen! Feel free to email me for further details wur.nl/en/vacancy/postdoc-wi… RT appreciated!
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Really nice glimpse into our department!
Physical Chemistry and Soft Matter - WUR@PCC_WUR19 Apr 2022
Interested in knowing more about PCC...we made a video: youtube.com/watch?v=AQE2QfeX…

A tour of the PCC group at Wageningen University

Enjoy the videos and music you love, upload original content, and share it all with friends, family, and the world on YouTube.

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Siddharth Deshpande retweeted
Sabina Caneva@SabinaCaneva8 Mar 2022
We are hiring!💡We're looking for a creative PhD student to join our #ERC SIMPHONICS team, focusing on #nanodevices and #nanopore platforms for single-molecule transport and detection. Interested? Apply here tinyurl.com/bdhw63j6 Please RT 🙂
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A new twist on using the biopolymer actin and condensates to form biocompatible synthetic cell containers. A nice news article on the recent actinosome pre-print by @SiddhuLab and @ketanganar. drugdiscoverynews.com/resear…

Researchers use actin to develop synthetic condensates | Drug Discovery News

Cell membranes act as containers for cell contents. Synthetic cells need them too. Researchers developed a new vessel that uses an unusual border: actin.

drugdiscoverynews.com
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Very happy to receive the NWO-XS grant! A nice end-of-the-year bonus for the lab and a great way to start the vacation! We want to sub-compartmentalize synthetic cells, which is not a bad idea I think 😉 Thank you @NWO_Science nwo.nl/en/news/twentysix-gro…
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Our January issue is online! Microbial soil inoculants (@DrMicroWill), lab evolution on a chip (@SiddhuLab @MIB_WUR), adipose tissue engineering (@Khoonono @Tim_WoodfieldNZ), bioelectronic sensing (@_annamariapappa @biochemist_hero) and more: cell.com/trends/biotechnolog…
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Check out our work on building biosensors using pretty liquid crystal droplets! We detect amphiphile-specific color response and even tested it in vivo! Fantastic work by @lwhonaker and special thanks to @sylvia_brugman for feeding zebrafish our sensors! biorxiv.org/content/10.1101/…
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Condensate-membrane interactions leading to vesicle reshaping! Looking amazing! Congratulations!
Dimova Lab now at @DimovaLab.bsky.social@DimovaLab11 Nov 2021
Molecular condensates in vesicles reshape membranes to produce kinks & nanotubes but super-resolution STED is super enough to resolve them all @MpiciPotsdam @PotsdamScience @AdvSciNews Thanks to Ziliang Zhao (now @AgEggeling) @ja_steinkuehler @LabRobinson bit.ly/3qt2BGL
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Great to see OLA, an on-chip liposome production method that I developed with @cees_dekker being highlighted by @Fluigent
KeyserLab@KeyserLab9 Nov 2021
Giant unilamellar vesicle production and testing! @Fluigent based on @cees_dekker OLA method fluigent.com/resources/succe…
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Glad you liked it! Yeah, some really interesting work from my PhD student @ketanganar very excited to see how it evolves further...
Kate Adamala@KateAdamala30 Oct 2021
Step towards synthetic cell cytoskeleton and fully engineered morphology. Actinosomes: condensate-templated proteinaceous containers for engineering synthetic cells biorxiv.org/content/early/20… Inspiring work from @SiddhuLab, with stunning microscopy images.
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Save the date! SynCell2022 will take place from 18 to 20 May 2022 in Delft.
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It was an absolute pleasure and an honor to be on the PhD committee of Ariane Stucki from @BioanalyticsLab led by Petra Dittrich! A big congrats to Ariane for a fabulous thesis! Plus, how could I miss a trip to beautiful Basel, my alma mater 🤩
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Very interesting work! Congrats @SpruijtLab
SpruijtLab@SpruijtLab13 Oct 2021
More exciting news! @DrManzarsial his discovery has lead to an outstanding paper in @NatureChemistry. Also big congratulations to @WojtekPLipinski and @karinakinuyo. A new minimal system for #protocells based on #coacervate: nature.com/articles/s41557-0…
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