Ph.D. Scholar @IISERPune @Hari_Chakrapani Lab l Chemical Biologist l Alumnus of Institue of Science Nagpur
Joined June 2023
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It has been an exciting journey to develop new substrates for a sulfurtransferase to enhance hydropersulfides and rescue cells from ferroptosis. Heartfelt thanks to @Hari_Chakrapani, and collaborators @Dharma_IITK @STakaaki26424, @kamatsid,and @santhoshd22
@angew_chem
We used hydrogen sulfide to rescue cells from ferroptosis, an important stress mechanism. Spearheaded by graduate student @SimranGupta2312; Wonderful collaboration with @Dharma_IITK
@kamatsid @iiserpune @tohoku_univ @angew_chem onlinelibrary.wiley.com/doi/…
@ANRFIndia
🎓 A few days ago, I successfully defended my PhD thesis at @IISERPune
Grateful to my supervisor, @Hari_Chakrapani, for his guidance and mentorship, and to my labmates, collaborators, friends, and family for their support throughout the journey
Excited for what lies next! ✨
Congratulations to us on this publication! Thank you for your valuable insights and thoughtful discussions throughout this work.
Fantastic work this from @SimranGupta2312 @Hari_Chakrapani @IISERPune. Glad I could be a part of it !!!
Thrilled to see our work published! It was my pleasure collaborating with you on this project. Thank you, @santhoshd22, for your valuable contribution and support throughout this work.
Very happy to see this collaborative work on @ferroptosis in @angew_chem with @Hari_Chakrapani's lab. Grateful for the opportunity and loved testing the hypothesis. @SimranGupta2312 @santhoshd22 Congratulations to the entire team! 🙏❤️🔥
Participated in Redox Week Conference last week in Sendai. I had the privilege of delivering an oral presentation on my PhD research, as well as presenting a poster. Extremely thankful to my PhD supervisor @Hari_Chakrapani for his guidance.
redoxweek2025.jp/
@IISERPune
Honored to be selected for the Japan Sakura Science Exchange Program, Japan Science and Technology Agency and have started my journey. Many thanks to Prof. Takaaki Akaike @STakaaki26424 and his lab at Tohoku University, Japan for the warm welcome. Looking forward to this journey.
Simran Manoj Gupta retweeted
Tandem Biocatalysis to Generate Hydrogen Sulfide and Promote Endogenous Antioxidant Response (Harinath Chakrapani and co-workers) @hari_chakrapani @iiserpune • onlinelibrary.wiley.com/doi/…
Delighted to start 2025 with the publication of my latest first-author paper with @sumanchemX in @angew_chem Extremely grateful for the guidance and support from my mentor @Hari_Chakrapani throughout this journey. Looking forward to the next chapter in my research. @IISERPune
Pleased to share our latest manuscript "Tandem Biocatalysis to Generate Hydrogen Sulfide and Promote Endogenous Antioxidant Response" has been accepted in Angewandte Chemie International Edition onlinelibrary.wiley.com/doi/…. @KamatLab_IISER @ANRFIndia @IISERPune
Beyond excited to announce my first-ever first-author paper published in Chemical Science! Deeply grateful to my supervisor, @Hari_Chakrapani , for his invaluable guidance, and to my wonderful labmates. Here’s to new beginnings! @IISERPune @ChemicalScience
#MyFirstChemSci
Pleased to share our first manuscript in 2025 published in @ChemicalScience pubs.rsc.org/en/content/arti…. Congratulations @SimranGupta2312 and Pratiksha! @IISERPune @IndiaDST @ANRFIndia for funding.
Heartiest Congratulations to Prof. Siddhesh Kamat @KamatLab_IISER @IISERPune
#InfosysPrize2024 in Life Sciences is awarded to Prof. Siddhesh Kamat, @KamatLab_IISER, of @IISERPune for his discoveries concerning bioactive lipids and their receptors, and their metabolic and signaling pathways. His research using advanced methods to understand the function of lipids, a key component of cells, has important implications for understanding the role of these molecules in a range of cellular functions and human diseases.
Participants of the Indo-German Meeting #ECBS-2024 at Le Meridien Amritsar, coinciding with 50 years India and Germany S&T cooperation.@INDOGSTC @GermanyinIndia Excited to share that I’m participating this year! Looking forward to connecting with experts, learning new ideas.
Simran Manoj Gupta retweeted
A backdrop like no other for the conference group photograph! Special place and special occasion, with special friends. Splendid time!
India 🇮🇳 🇮🇳
Simran Manoj Gupta retweeted
Participants of the Indo-German Meeting #ECBS-2024 at Le Meridien Amritsar, coinciding with 50 years India and Germany S&T cooperation. Anticipating complex multidisciplinary science, involved interactions and useful collaborations. @INDOGSTC @GermanyinIndia
Simran Manoj Gupta retweeted
Delighted to share our foray into selenium chemistry - now published in @ChemicalScience pubs.rsc.org/en/content/arti… Congratulations @DeySarkar2 and Mahima! Thanks @IISERPune @ChemistryIISERP @serbonline for funding. @RoySocChem
Simran Manoj Gupta retweeted
We're looking for a highly motivated and enthusiastic Research Associate with expertise in organic synthesis and mechanisms, and a demonstrated research track record. Those interested may please check the link: iiserpune.ac.in/opportunitie…
Simran Manoj Gupta retweeted
Happy to share a new paper (@BiochemistryACS) from the lab @IISERPune assigning PLC-type activity with specificity towards phosphatidylinositol lipids to an uncharacterised lipase CG17192 in flies during infection. Wonderful work led by @Kundan703. pubs.acs.org/doi/10.1021/acs…
Simran Manoj Gupta retweeted
As killing latent HIV-1 is almost impossible hence our strategy may enable us to kill and clear HIV-1 viruses (known as the Shock and Kill strategy). Many thanks to my PhD supervisor @Hari_Chakrapani, and collaborators (Amit Singh lab & @AdhesionLab ). onlinelibrary.wiley.com/doi/…
Simran Manoj Gupta retweeted
Extremely pleased to share my publication in Angewandte Chemie.
Started this project just before the COVID-19 viral pandemic. Only had NMR and some preliminary data. Never thought that this could lead to interrogation of HIV-1, another deadly virus.
Simran Manoj Gupta retweeted
Using this tool, we studied the effect of mitochondrial H2S on human immunodeficiency virus (HIV-1) and mitochondrial H2S and persulfide profoundly affected the HIV-1 life cycle and may provide clues such to new drug design @Mito_News
Simran Manoj Gupta retweeted
Check out the latest probe from our lab: the cell’s biosynthetic machinery and localization is used to selectively generate H2S within mitochondria. Collaboration with Amit Singh and @AdhesionLab @suman_chembio @angew_chem
onlinelibrary.wiley.com/doi/… @IISERPune @ChemistryIISERP