The Foundation for Stroke Prevention. Steven Rudolph, MD, Director
New York
Joined February 2009
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Stroke Prevention retweeted
🧵 Part 1 of this two-part topical review by Lin and Cramer that explores neural repair after #stroke⚙️: Intensive training can improve function even in the chronic phase, while biological therapies and neural stimulation offer emerging paths to recovery. ahajournals.org/doi/full/10.…
ALT Graphic abstract in Lin and Cramer.
Stroke Prevention retweeted
Lifestyle changes we can all make every day to reduce stroke risk and improve brain health. Small steps can make a big difference! 🧠 🏥 || #Stroke #WorldStrokeDay @StrokeAHA_ASA @UofUNeurology @UofUHealth
Beyond Medications: This #WorldStrokeDay, #BloggingStroke contributor @AlexVorobyevMD highlights lifestyle changes that reduce #stroke risk. ahajournals.org/do/10.1161/b…
ALT Figure 1. Recommended lifestyle behaviors and evidence grades from the 2024 American Heart Association/American Stroke Association stroke prevention guideline; healthy sleep guidance from the American Heart Association Life’s Essential 8.1,2
Stroke Prevention retweeted
Among imaging-selected treatment beyond 4.5 hours or with unknown #stroke onset, IVT improved 90-day outcomes, with increased sICH rates but comparable mortality to BMT. ahajrnls.org/3UTdtPB
@thirumalai_vas @Stroke2Neuron @savetheneurons @FastTpa @UTHSC @uthscneurores
ALT Graphic abstract in Pitchan Velammal et al.
Editorial offering perspective on trends in care for #TIA, and directions for moving forward #stroke
jamanetwork.com/journals/jam…
Stroke Prevention retweeted
InterSECT by @mattfos89 & @luciodanna2 et al.: Antithrombotic therapy for secondary stroke prevention should match stroke mechanism, timing, bleeding risk, comorbidities, adherence, and access now. ahajrnls.org/3WcUsrJ
ALT Figure in Foschi and D’Anna et al.
Stroke Prevention retweeted
Among patients with acute ischemic #Stroke who underwent successful #EndovascularTherapy for anterior circulation large vessel occlusion, adjunctive intra-arterial tenecteplase was associated with a higher rate of excellent functional outcome at 1 year vs standard medical treatment.
Mortality at 1 year was similar between groups.
ja.ma/47HX0Rm
Stroke Prevention retweeted
Original Article: Trial of Endovascular Therapy for Mild Stroke with Large-Vessel Occlusion (MILD-MT trial) nej.md/4hWstFc
#Neurology #EmergencyMedicine
ALT Bar graph showing the percentage of patients on the Modified Rankin Scale, comparing "EVT plus Medical Management" (N=144) and "Medical Management Alone" (N=156). Scores range from 0 to 6. The distribution is labeled with percentages and number of patients for each category.
ALT A forest plot comparing EVT plus Medical Management to Medical Management Alone for various subgroups, showing adjusted odds ratios and confidence intervals. Subgroups include age, sex, time from onset to randomization, site of occlusion, cause of stroke, baseline NIHSS score, intravenous thrombolysis, and perfusion-mismatch volume.
Stroke Prevention retweeted
Original Article: Mechanical Thrombectomy 24 to 72 Hours after Large-Vessel Ischemic Stroke (LATE-MT trial) nej.md/3VWTUpV
Editorial: Expanding the Evidence and Indications for Thrombectomy in Ischemic Stroke nej.md/4hWsxVs
#Neurology #Surgery
ALT Bar graph showing the percentage of patients on the Modified Rankin Scale, comparing "Intervention" (N=167) and "Control" (N=167). Scores range from 0 to 6. The distribution is labeled with percentages for each category.
ALT This image shows a forest plot comparing the intervention and control groups. Subgroups include age, time from onset to randomization, and type of stroke. Hazard ratios with 95% confidence intervals are displayed, indicating whether the intervention or control is better for a primary outcome.
Stroke Prevention retweeted
More evidence supporting the use of DOACs for the treatment of cerebral venous thrombosis except when APLS is present. In this large meta-analysis, VKA and DOACs were equivalent, regardless of DOAC type. ahajournals.org/doi/10.1161/… @VancouverStroke @ShuLiqi @analugguarniz
Stroke Prevention retweeted
This joint Scientific Statement on behalf of @American_Heart, @AmerAcadPeds, @acog and the Society for Maternal-Fetal presents stage-specific clinical guidance across the interconnected domains of hormonal health, psychosocial health, and cardiovascular (CV) health across the female life course.
The three anchoring principles of this statement are:
(1) Endogenous sex hormones are dynamic and produce physiologic changes accessible without labs.
(2) Hormonal transitions (perimenarche, perimenopause, peripregnancy) are windows of opportunity that reflect changing vulnerability to psychosocial stressors and CVD risk.
(3) The framework makes explicit the interconnectedness of hormonal, psychosocial, and CV health.
@American_Heart, @AmerAcadPeds, @acog and the Society for Maternal-Fetal Medicine jointly approve this shared model.
📷 Female Life Stage chart assessing interconnected domains of hormonal, psychosocial, and cardiovascular health
✍🏼 @heartDocSadiya
professional.heart.org/en/sc…
Stroke Prevention retweeted
For the first time, @American_Heart, @AmerAcadPeds, @acog, and the Society for Maternal-Fetal Medicine have come together to release shared guidance to help clinicians identify cardiovascular risk early and take action.
The landmark three-part publication series highlights how female-specific biology affects girls’ and women’s hearts and creates a “Female Life Stage” framework to help protect heart health from puberty through menopause and beyond.
The Female Life Stage framework is based on female biology and offers windows of opportunity to prevent heart disease and stroke and manage future disease risk.
Each life stage is defined by a change in hormones that is uniquely experienced by girls and women, with pregnancy identified as an event affecting cardiovascular health that may occur at any or multiple life stages:
➡️ Stage 1 perimenarche - This stage represents the transition after the first menstrual period. Approximate age range is 8 – 15 years.
➡️ Stage 2 ovarian cycling - Regular ovulatory and hormone cycles are established and when pregnancy may occur. Approximate age range is 15 – 44 years.
➡️ Stage 3 perimenopause - This stage represents the transition to variable cycle length, skipped cycles and hormone changes. Approximate age range is 45-51 years.
➡️ Stage 4 postmenopause – This stage represents the years that begin after menopause or 12 months after the final menstrual period. Approximate age is 51 years and older.
➡️ Pregnancy, in any life stage – the time before, during and after pregnancy is highlighted as a biological “stress test” that can identify cardiovascular risks that may have been previously unrecognized.
✍🏼 @heartDocSadiya
📷 The Female Life Stage framework for the prevention and management of cardiovascular disease in girls and women
professional.heart.org/en/sc…
Stroke Prevention retweeted
Presented at #SleepEurope2026:
In two phase 3 trials involving participants with OSA and obesity or overweight with or without type 2 diabetes, treatment with retatrutide was found to result in greater decreases in the apnea–hypopnea index than placebo. Full results of the TRIUMPH-1-OSA and TRIUMPH-2-OSA trials: nej.md/4BmAHOI
@ESRS_Sleep
![A graph from the Original Article “Retatrutide Once Weekly for Treatment of Obstructive Sleep Apnea.” The names of the two trials, TRIUMPH-1-OSA and TRIUMPH-2-OSA, are in parentheses after the title. The graph] shows the change in AHI among participants in TRIUMPH-1-OSA. The trial results are being presented at the European Sleep Research Society 2026 Congress. The logo of the New England Journal of Medicine is at the bottom.](https://pbs.twimg.com/media/HVIgx-QXsAAXxRZ.jpg?name=orig)
ALT A graph from the Original Article “Retatrutide Once Weekly for Treatment of Obstructive Sleep Apnea.” The names of the two trials, TRIUMPH-1-OSA and TRIUMPH-2-OSA, are in parentheses after the title. The graph] shows the change in AHI among participants in TRIUMPH-1-OSA. The trial results are being presented at the European Sleep Research Society 2026 Congress. The logo of the New England Journal of Medicine is at the bottom.
Stroke Prevention retweeted
Long-awaited results of CREST-H are out. @MayoClinicNeuro Revascularization in Asymptomatic Carotid Artery Stenosis With Hemodynamic Impairment jamanetwork.com/journals/jam…
Stroke Prevention retweeted
This review indicates that there is no clear, well-supported recommendation to administer DDAVP to patients with antiplatelet-associated #ICH. Anfd there was also a soft signal towards more thromboembolic events.
link.springer.com/article/10…
Stroke Prevention retweeted
Rather than treating limited health literacy as a fixed patient trait, the statement calls for healthcare systems and interprofessional teams to redesign how stroke education and communication are delivered.
The evidence for nurse-led literacy interventions is encouraging but still developing, and the statement is candid about the gaps: few adequately powered trials, inconsistent outcome measures, and a lack of tools validated for the aphasia, limited-English-proficiency, and cognitively impaired survivors who need them most.
This scientific statement synthesizes current evidence on health literacy and communication across the entire stroke continuum, from prevention through recovery, and identifies nurse-led opportunities to advance equity and patient-centered outcomes.
📷 Conceptual framework for advancing health literacy and effective communication across the stroke continuum
ALT This is a document titled "Health Literacy and Communication in Stroke Prevention, Management, and Recovery: A Scientific Statement From the American Heart Association."
Stroke Prevention retweeted
EVT treatment effect in MeVO #stroke across perfusion mismatch profiles in ESCAPE-MeVO! @JAMANetworkOpen @johanna_ospel @mayank_G0 @draravindganesh @MDStebnerAl @ESOstroke jamanetwork.com/journals/jam…
Stroke Prevention retweeted
Your doctor cuts you off about 11 seconds after you start talking. Researchers literally timed it in a 2018 study. That number is why Google's new Lancet result is bigger than it looks.
In the study, 98 real urgent care patients texted with Google's AI days before their appointment. No scans, no exam, no bloodwork, just an unhurried conversation about what was wrong. That alone put the correct final diagnosis on the AI's list 90% of the time.
Sounds like magic until you learn what medicine has known for 50 years.
Back in 1975, a British team published a study in the BMJ tracking which part of a visit actually produced the right diagnosis. The physical exam? The labs? Nope. In 82% of cases, the patient's story alone got the doctor there. Everything else mostly confirmed what listening had already found.
So the playbook for accurate diagnosis has existed since 1975. Let the patient talk. Medicine just built a system where nobody has time to run it, and an 18-minute appointment with 11 seconds of uninterrupted patient talk was the result.
Google didn't build a superhuman doctor. It built the first clinician in 50 years with enough time to use the method we already proved works.
And my favorite detail buried in the study... physicians who read the AI's pre-visit summary said it changed how they treated the patient in over half of cases. Hand a doctor the full story before you walk in the room and you get different medicine.
Turns out the most advanced medical instrument Google ever shipped is a conversation that doesn't get interrupted.
Today @TheLancet published our AMIE study with @BIDMC_Medicine, the first prospective study of patient-facing conversational diagnostics in a real clinic.
AMIE is a research system people can chat with before doctors appointments. Testing AMIE outside the lab with real urgent care patients showed how technology can help gather medical histories safely. Clinicians reported that the summaries helped them prepare for visits in 75% of cases and influenced their approach to care in more than half. AMIE’s differential diagnoses also matched the doctors’ final diagnoses 90% of the time giving clinicians more time to focus on patient care.
It’s Google’s first-ever paper in The Lancet’s main journal!
Stroke Prevention retweeted
Meta-analysis of almost 5K patients validating the fact that treating penumbral tissue on CTP with IV lytic therapy between 4.5-24 hours improves outcome — despite a small increase in ICH risk
@GreenJournal
neurology.org/doi/10.1212/CP…
Stroke Prevention retweeted
The American Heart Association convened 75 multidisciplinary experts for the Amyloid‐Related Imaging Abnormalities Summit: Cardiovascular and Stroke Considerations for β‐Amyloid Immunotherapy in AD in July 2025.
This outlines the outcomes of the Summit, including considerations for prescribers, primary care professionals, emergency personnel, and health care system stakeholders.
@SMGreenbergNeur @costantinoiade1 @SherryChou399 @MitchElkind @BJHicksMD @lauren_massimo @sudha_md @KristineYaffe @k_sauser
Stroke Prevention retweeted
Central adiposity and systemic inflammation partially mediate the association between ultra-processed food consumption and #CVD risk, according to a study published in #JACCAdvances.
Get full details ➡️ bit.ly/3UaG1DT #CardioX
