@SumnerLab

we study the inherited neurodegenerative disorders SMA and CMT @hopkinsmedicine

 Baltimore, MD
sumnerlab.com/
Joined February 2021
  • Tweets45
  • Following66
  • Followers120
7Media
For #SMAAwarenessMonth 💜 we want to highlight new research offering hope for treating spinal muscular atrophy before birth. The @MackenzieTippi lab and @SumnerLab found that intra-amniotic delivery of SMN2 ASOs improved survival and motor function in SMA mouse models, surpassing outcomes of postnatal treatment.
Science Translational Medicine@ScienceTM16 May 2025
Antisense oligonucleotides injected into amniotic fluid led to healthier motor neurons, improved behavior and survival in mouse models of spinal muscular atrophy. @HopkinsMedicine @UCSFMedicine scim.ag/43kciJ4
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After many years of amazing work, Dr. Jeremy Sullivan's paper (@SumnerLab ) is finally out and TRPV4 expression in brainstem blood vessels made the cover! science.org/doi/10.1126/scit…

Gain-of-function mutations of TRPV4 acting in endothelial cells drive blood-CNS barrier breakdown...

TRPV4-mediated BSCB breakdown is a reversible driver of motor neuron degeneration in mice.

science.org
Science Translational Medicine@ScienceTM22 May 2024
This week's new issue of #ScienceTranslationalMedicine has arrived! Epigenetic clues can predict the risk of kidney failure in patients with type 1 diabetes, an experimental antiviral neutralizes an array of coronaviruses in mice, and more. scim.ag/73c
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Congratulations to @CMM_JHU Anna Bagnell @abagnell_sci for winning the @JohnsHopkins Empower Your Pitch competition! Anna studies the role TRPV4 plays in regulating blood neural barriers in the @SumnerLab at @HopkinsMedicine.
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Via @MuscleAndNerve: Children diagnosed with spinal muscular atrophy as infants and treated with nusinersen achieved motor milestones previously unattainable for children with the disease: bit.ly/3Lk3j2v #NeuroTwitter @CHOP_Research @JinsyMd @SumnerLab @HopkinsMedicine
A woman's hand caresses the hand of a newborn.

ALT A woman's hand caresses the hand of a newborn.

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It’s online today!! So excited to share 🤩 Feels unreal to see it official after all those years. Ilaria started the project 10y ago, Liza did the bulk of it for her PhD & I completed it all (added some ASO/therapeutics & perfected the looks of it 😉) sciencedirect.com/science/ar…
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When dreaming about TRP channels, dream BIGGER! Our new pre-print "Crosstalk between regulatory elements in the disordered TRPV4 N-terminus modulates lipid-dependent channel activity" is finally out! biorxiv.org/content/10.1101/…
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Congratulations to @HopkinsMedicine ‘s @SumnerLab !
American Neurological Association@ANAneurology23 Jul 2021
We are pleased to announce the recipients of the ANA's 2021 scientific awards, to be presented during #ANA2021. 🎉 Congratulations to this year's winners! ow.ly/HNzj50FCz6Y
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After fantastic talks yesterday, including the breathtaking take on TRPV4 channelopathies by @SumnerLab, now a fascinating historic perspective and the connection to TRPA1 by @sejordt at the 20 years of TRPV4 conference! What will we talk about in another 20 years?!🤯 #ISCxTRPV4
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Spinraza (nusinersen) will be available to people with spinal muscular atrophy type 3 who are unable to walk. Patient organizations advocated the decision. Read more about it here: buff.ly/3uYzZo9
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The TRPV4 ion channel was first published in 2000 by our friend and long-time collaborator Wolfgang Liedtke. Please join us June 8-11, 2021 for a virtual conference to celebrate 20 years of progress on #TRPV4 by scientists around the world insidescientific.com/virtual… (Please RT!)
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This paper has everything - the best protein (TRPV4!), disease mutants, mechanisms, cells, flies and even NMR! Exciting work by @SumnerLab on how TRPV4 neuropathy but not skeletal dysplasia mutants disrupt RhoA interaction & neurite extension! nature.com/articles/s41467-0…
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Sumner Lab retweeted
Cure SMA
@CureSMA16 Feb 2021
Given the current state of the pandemic and COVID-19 vaccination roll-out, Cure SMA will hold its 2021 #AnnualSMAConference virtually again this year. Although we wish we could see you in-person this year, we hope you can join us! 💜🧡 Learn more: 👇 curesma.org/annual-sma-confe…
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Congratulations to CSHL Professor Adrian Krainer for winning the 2021 @WolfPrize_ in Medicine for his work on RNA splicing. cshl.edu/krainer-wins-2021-w…

Krainer wins 2021 Wolf Prize in Medicine | Cold Spring Harbor Laboratory

Cold Spring Harbor Laboratory (CSHL) Professor Adrian Krainer has been awarded the 2021 Wolf Prize in Medicine. Krainer was chosen for his contributions in biochemistry and molecular genetics and his...

cshl.edu
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