@TCrispr

CRISPR videos by CRISPR scientists

youtube.com/c/TalkingCRISPR
Joined June 2018
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  • Following33
  • Followers547
40Media
Such a pleasure talking with @JacquesHughes about our findings. Big thanks to the @NaturePodcast team for having me! Tune in to the episode to hear our conversation🦠🎙️ nature.com/articles/d41586-0…
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Talking CRISPR retweeted
Gisle Vestergaard@gisleDK13 Apr 2023
Replying to @TCrispr
@TCrispr lays out his brilliant paper on phages in childrens gut. I remember once thinking "Wow, we identified a handful of new viral families!". Shiraz and the rest of this group just found +100 new ones 🤯 Check out the brilliant online overview 👇 tiny.cc/aq76vz
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1/n Excited to share a story on prokaryotic Argonautes (pAgos)!! 🎉 Here, we describe a short pAgo that mediates robust antiviral protection!🛡️ But how!? 🧵👇 biorxiv.org/content/10.1101/…

A short prokaryotic argonaute cooperates with membrane effector to confer antiviral defense

Argonaute (Ago) proteins are widespread nucleic acid-guided enzymes that recognize targets through complementary base pairing. While in eukaryotes Agos are involved in RNA silencing, the functions of...

biorxiv.org
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Very excited to see our story online in @NAR_Open!🎉 We found plasmids in nature carry a fascinating diversity of CRISPR-Cas🌈🤯 We characterized their abundance, diversity, distribution & investigated their CRISPR contents to infer their function(s)!! academic.oup.com/nar/advance…

CRISPR-Cas systems are widespread accessory elements across bacterial and archaeal plasmids

Abstract. Many prokaryotes encode CRISPR-Cas systems as immune protection against mobile genetic elements (MGEs), yet a number of MGEs also harbor CRISPR-C

academic.oup.com
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Talking CRISPR retweeted
Simon Rasmussen@simonrasmu9 Jul 2021
Binning #viral / #phage genomes directly from #metagenomics data while automatically defining #viralpopulations across samples? Now you can using PHAMB - new tool to run on top of VAMB (or another binner)! Fantastic work led by @joachim from my group: biorxiv.org/content/10.1101/…

Genome binning of viral entities from bulk metagenomics data

Despite the accelerating number of uncultivated virus sequences discovered in metagenomics and their apparent importance for health and disease, the human gut virome and its interactions with...

biorxiv.org
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Omer Alkhnbashi@amri2k21 Jun 2020
We're pleased to share our new work on CRISPR-Cas. The CRISPRcasIdentifier clearly outperforms all other available tools on the most recent and comprehensive CRISPR-Cas classification dataset(F-score of 0.91) academic.oup.com/gigascience…

CRISPRcasIdentifier: Machine learning for accurate identification and classification of CRISPR-Cas...

AbstractBackground. CRISPR-Cas genes are extraordinarily diverse and evolve rapidly when compared to other prokaryotic genes. With the rapid increase in ne

academic.oup.com
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Moïra Dion, PhD@moira_dion3 Feb 2020
Writing this review got me even more fascinated by phages!
Nature Reviews Microbiology@NatureRevMicro3 Feb 2020
Phage diversity, genomics and phylogeny Dion, Oechslin and Moineau explore the diversity of phages at the structural, genomic and community levels as well as their complex evolutionary relationships. nature.com/articles/s41579-0… @smoineau @moira_dion
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Sylvain Moineau@smoineau22 Jan 2020
Great international collaboration ! Congrats, Aurélie, Marie-Agnès, @moira_dion @TCrispr,@COPSAC_com et al ! @NatureComms disq.us/t/3ld63j4
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NEW REVIEW: Koonin and colleagues provide an updated classification of CRISPR-Cas systems and outline a complete scenario for their origins and evolution nature.com/articles/s41579-0…

Evolutionary classification of CRISPR–Cas systems: a burst of class 2 and derived variants

Nature Reviews Microbiology - The number and diversity of known CRISPR–Cas systems have substantially increased in recent years. In this Review, Koonin and colleagues provide an updated...

nature.com
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Gisle Vestergaard@gisleDK14 Nov 2019
Long-read metagenomic exploration of extrachromosomal mobile genetic elements in the human gut In 413 gut metagenomes from five countries, many of the identified plasmids were highly abundant. Plasmids outnumbered bacterial chromosomes three to one. bit.ly/2Oc6Bqb
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Online Now: Direct Visualization of Native CRISPR Target Search in Live Bacteria Reveals Cascade DNA Surveillance Mechanism dlvr.it/RJHdqC
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Omer Alkhnbashi@amri2k31 Oct 2019
Our new preprint is online on identifier and classifier of CRISPR-Cas proteins using machine learning approaches. biorxiv.org/content/10.1101/…

CRISPRCasIdentifier: Machine learning for accurate identification and classification of CRISPR-Cas...

CRISPR-Cas genes are extraordinarily diverse and evolve rapidly when compared to other prokaryotic genes. With the rapid increase in newly sequenced archaeal and bacterial genomes, manual identific...

biorxiv.org
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The pan-immune system of bacteria: antiviral defence as a community resource Bernheim and Sorek present the ‘pan-immune system’ model in which bacteria employ horizontal gene transfer to access immune defence mechanisms encoded by closely related strains rdcu.be/bWgoC
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What are friends for? When bacteria are attacked by deadly phage virus they emit a warning signal to their neighbouring friends so they can stay clear of the danger zone. jb.asm.org/content/201/23.co… #phagedefense #pseudomonas @JBacteriology Thanks to @lundbeckfonden for support.
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Replying to @rossbenjamind @ajverster
Very happy to have our work published today! Huge thanks to @ajverster, @DanicaSchmidtk1, Joseph Mougous, Elhanan Borenstein and many others not on Twitter. nature.com/articles/s41586-0…

Human gut bacteria contain acquired interbacterial defence systems

Nature - An interbacterial defence strategy, involving clusters of immunity genes against toxins released by the type VI secretion system of the same or different species, is widespread among...

nature.com
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In today's episode of things that probably only annoy me... I know that CRISPR adaptive immunity originated before siRNAs and piRNAs in eukaryotes. But the latter were mechanistically described much earlier. 1/2
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Talking CRISPR retweeted
Mar Albà@maralbasoler16 Oct 2019
How evolution builds genes from scratch nature.com/articles/d41586-0… Adam Levy reports for @NatureNews on #denovogenes

How evolution builds genes from scratch

Nature - Scientists long assumed that new genes appear when evolution tinkers with old ones. It turns out that natural selection is much more creative.

nature.com
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Cell@CellCellPress3 Oct 2019
Article in this issue of Cell: Inhibition of Type III CRISPR-Cas Immunity by an Archaeal Virus-Encoded Anti-CRISPR Protein - cell.com/cell/fulltext/S0092…
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Excited to finally share this preprint! Here we provide insights into the diversity, biology and evolution of the elusive type IV CRISPR systems! Some takeaways from our story: 1/12
bioRxiv Microbiology@biorxiv_micrbio25 Sep 2019
Type IV CRISPR-Cas systems are highly diverse and involved in competition between plasmids biorxiv.org/cgi/content/shor… #biorxiv_micrbio
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Talking CRISPR retweeted
Cell@CellCellPress26 Sep 2019
Online Now: #Viruses infecting the #archaea member Sulfolobus encode an inhibitor of the type III-B #CRISPR-Cas system of their host, which inhibits CRISPR-based targeting of viral middle & late genes - Xu Peng and colleagues fm @uni_copenhagen bit.ly/2lnUlIL
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