those who do not make history are doomed to retweet it. founder @biopunklab prev. @spirainc @deepsciventures First Venusian astronaut. bio/acc

San Francisco, CA
Joined April 2009
When my kid asks "How are babies made?", I'm going to say "A doctor combines a sperm and egg in a test tube, and then freezes it until Daddy's startup has a liquidity event"
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I had considered doing this for cats but 1) cats are already optimized for war and 2) historically cats have not aligned with NATO
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We've heard this story before about creating spinoff companies that outlicense the tech of an underlying biotech company as the main business model... I don't think it worked well for ginkgo and they're just focused on revenue-generation now
Today, I’m launching NeoGenesis Capital with @YianniPsaltis. Five years ago, I became an early investor in @Colossal Biosciences. Then @BenLamm and @Geochurch built a platform at the intersection of Superintelligence and Synthetic Biology that can build living products… programmable biology. NeoGenesis invests in Colossal and the spinout companies built on their platform across food, environment, entertainment, security, and species reconstruction.
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Elliot Roth || SF retweeted
Introducing Carbon-X: The best open DNA model. We midtrained a 14B model on DNA and text, and it beats every open language model and matches GPT-6.1 Sol at 1,000x lower cost. Ask it about a sequence, what a mutation does, or to generate new DNA. huggingface.co/HuggingFaceBi…
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I believe that man will not merely endure: he will prevail. He is immortal, not because he alone among creatures has an inexhaustible voice, but because he has a soul, a spirit capable of compassion and sacrifice and endurance. nobelprize.org/prizes/litera…
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Elliot Roth || SF retweeted
In January 2025 my mom’s lung cancer spread to her brain. The drug with the best chance of helping her was approved in China but not here. A doctor told me, almost as an aside, that if she were Chinese she could buy it at a pharmacy. So I flew to Shanghai and came home with 26 boxes in my luggage. That was 19 months ago. My mom is still here, still working, and in her words has had an amazing three years. The drug was approved in China in 2023. The FDA approved it in July 2025. It still is not for sale here. I know of at least 30 Americans who have made the same trip. I have been scared to tell this story because I worried it could cost my mom access to the medicine keeping her alive. But the problem matters more than my silence. These drugs need to be developed and available here, and that means FDA reform. Art Allen at KFF Health News told our story this week. It also ran in The Washington Post. kffhealthnews.org/health-ind…
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sick. Do a kickflip next.
On December 30, 1952, London bus driver Albert Gunter dramatically jumped his Route 78 double-decker bus across a rising gap on Tower Bridge. Realizing the bridge was lifting unexpectedly on a green light, the former WWII tank driver accelerated, clearing the opening with 20 passengers on board.... With 20 terrified passengers on board, the red Routemaster leaped across a three-foot gap as the bridge continued to lift. The front wheels landed safely on the opposite side, though the impact broke the suspension and injured Gunter’s leg. Miraculously, everyone survived with only minor injuries. Albert was later rewarded with a £10 bonus for his bravery — roughly £400 today — and became a London legend. His daring leap remains one of the most extraordinary moments in public transport history. #drthehistories
Readers added context they thought people might want to know
The image attached here is a fabricated/AI-generated depiction that greatly exaggerates the 1952 event; no real photo of the bus jump exists and the actual gap was only about 3 feet. leadstories.com/hoax-alert/202… en.wikipedia.org/wiki/1952_Towe… bbc.co.uk/news/articles/…
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Amazing people. Amazing role. Sophia is brilliant and endlessly creative. Highly recommend you apply!
Andreas Tolias & I are hiring a Chief of Staff to work closely with us at @metamorphiclabs. Seeking a high-agency generalist with strong judgment and exceptional execution who thrives in a dynamic environment and has a track record of owning complex projects from ambiguity to results. You’ll work directly with us across strategic projects, fundraising, partnerships, and business operations, with substantial autonomy and room to grow. If this sounds like you or someone you know, we’d love to connect. About Metamorphic: metamorphic.com Role & Application: lnkd.in/gYp-b3c3
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Elliot Roth || SF retweeted
A few more folks I found out through this post: 1/ @andrewjrod curing his gf @amydeng_'s brain tumor 2/ @Iammarcmalone 3x'ing his wife's survival time and eliminated her cancer stem cell. Published and peer reviewed. Still passed unfortunately. Now helping save his son, who has dozens of genetic disorders, terminal mutations, and very severe disabilities (including severe Autism 3/ @ShyanneBatch stage IIIC cervical cancer. Looking at off the shelf vaccines for HPV targets 4/ @SheDaresLive Stage 4 inoperable pancreatic cancer for 4 years. Goal: Reach 10 new people affected by stage 4 cancer every day.
People who cured / are curing their own cancer on X: 1/ @sytses - bone cancer, billionaire founder of Gitlab, developed 10+ personalized therapies for himself. 2/ @paul_conyngham - shrank his dog Rosie's mast cell cancer tumors after chemo and surgery weren't enough. Now backed by YC and Founders Fund 3/ @miriamgonp - stage 4 breast cancer, tumor sequenced, searching for vaccine manufacturer now 4/ @kevinace - stage 4 lung cancer, angel investor in 300+ companies, first drug stopped working after 18 months. Vaccine designed, now paying $300k out of pocket for the vaccine 5/ @masonbgrant: going founder mode on his his 32-year-old wife's rare liver cancer, sequencing her tumor with AI agents 6/ @ArunRLverma: former product leader at Atoms and Shopify, brain tumor, built a vaccine from his tumor. Now building an AI health agent startup based on what he went through We're going to make it
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Elliot Roth || SF retweeted
So excited to announce our Request for Startups is live! Ten categories we want to fund at the earliest stage. Applications for the next Haus batch open soon. hausfund.substack.com/p/were…
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Elliot Roth || SF retweeted
Anthony de Mello 🗣️ “A good way to discover your shortcomings,” said the Master, “is to observe what irritates you in others.” "Live your life as you see fit. That's not selfish. Selfish is to demand that others live their lives as you see fit." "Seek to change yourself, not other people. It is easier to protect your feet with slippers than to carpet the whole of the earth." "If people want happiness so badly, why don’t they attempt to understand their false beliefs? First, because it never occurs to them to see them as false or even as beliefs. They see them as facts and reality, so deeply have they been programmed." “As soon as you look at the world through an ideology you are finished. No reality fits an ideology. Life is beyond that. … That is why people are always searching for a meaning to life… Meaning is only found when you go beyond meaning." “People who want a cure, provided they can have it without pain, are like those who favour progress, provided they can have it without change.” “The world is full of sorrow. The root of sorrow is attachment. The uprooting of sorrow means the uprooting, the dropping of attachments.” "Sinners often speak the truth. And saints have led people astray. Examine what is said, not the one who says it." “Suffering occurs when you clash with reality. When your illusions clash with reality, when your falsehoods clash with truth, then you have suffering. Otherwise there is no suffering.” “All I can do for you is help you to unlearn. That’s what learning is all about where spirituality is concerned: unlearning, unlearning almost everything you’ve been taught. A willingness to unlearn, to listen.” “Think of a flabby person covered with fat. That is what your mind can become—flabby, covered with layers of fat till it becomes too dull and lazy to think, to observe, to explore, to discover. It loses its alertness, its aliveness, its flexibility and goes to sleep. What are these layers? Every belief that you hold, every conclusion you have reached about persons and things, every habit and every attachment. In your formative years you should have been helped to scrape off these layers and liberate your mind. Instead your society, your culture, which put these layers on your mind in the first place, has educated you to not even notice them, to go to sleep and let other people—the experts: your politicians, your cultural and religious leaders—do your thinking for you. So you are weighed down with the load of unexamined, unquestioned authority and tradition.” “When you come to see you are not as wise today as you thought you were yesterday, you are wiser today.” “Of what use is it to be tolerant of others if you are convinced that you are right and everyone who disagrees with you is wrong? That isn’t tolerance but condescension.” “To be properly wicked, you do not have to break the Law. Just observe it to the letter.” “Certainty is the culprit. The spiritual person knows uncertainty—a state of mind unknown to the religious fanatic.” “Most people end up being conformists; they adapt to prison life. A few become reformers; they fight for better lighting, better ventilation. Hardly anyone becomes a rebel, a revolutionary who breaks down the prison walls. You can only be a revolutionary when you see the prison walls in the first place.” “The neurotic is a person who worries about something that did not happen in the past. He’s not like us normal people who worry about things that will not happen in the future.” “You listen,” said the Master, “not to discover, but to find something that confirms your own thoughts. You argue, not to find the truth, but to vindicate your thinking.” "Another illusion is that external events have the power to hurt you, that other people have the power to hurt you. They don't. It's you who give this power to them." "Enlightenment is: absolute cooperation with the inevitable." “If you see through yourself, you will see through everyone.”
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Five major databases of human surface proteins agree on only 188 of them. So we had Claude read the literature instead. Today @deliverome is releasing an open atlas of the accessible human surfaceome, with claims traced directly to quotes from their source 🎯
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Hell yeah @WoodingtonBen
This article stands on its own. Our XEIA portco, Coherence Neuro, just announced a $45M raise led by Founders Fund and OpenAI. Huge news. Coherence is building at the convergence of neurotechnology, AI and BCIs to launch cancer medicine into the future. This will be the world's first bi-directional implant for treating cancer. wired.com/story/openai-start…
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Fuck faxes
Personalized mRNA cancer vaccine: 2026 science. Nobody in my care did anything wrong. That's what makes it insane.
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Love the intentionality in design
Do you know the meaning of the @NousResearch logo? The girl is called the "Nous Girl". She was drawn in July 2023 by Nous's first artist, who goes by John Galt. Yes, the Atlas Shrugged rebel She stands for the rebellion of decentralized AI, and for keeping our humanity in the face of censorship and machine intelligence The words around her: "Rebellion to tyrants is obedience to God." That line goes back to 1776. Jefferson, Franklin and Adams put it on their proposed Great Seal of the United States. Congress said no, so Jefferson put it on his own personal seal instead Nous pointed it at AI. Today's tyrants are closed labs and gatekeepers deciding who gets access to intelligence. The rebellion is open weights, open agents and open infrastructure. That's why I build on Hermes Wearing it proudly 🏴
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We are on the cusp of a wave of new therapies for some of the worst diseases. But the world won’t benefit unless the US fixes its drug regulatory system. My new essay for @nytimes, on how slow clinical trials are now the biggest obstacle to curing cancer. nytimes.com/2026/09/04/opini… - I interviewed dozens of researchers, especially oncologists at leading U.S. centers. A striking consensus emerged: science is no longer the main bottleneck to new cancer drugs. It is our ability to test discoveries in patients through clinical trials. - The cost of starting a Phase 1 trial in America has roughly doubled over the past decade. As a result, companies increasingly take early trials abroad: Australia’s Phase 1 trial volume has nearly doubled in a decade, driven mainly by U.S. companies. - Unfortunately, the underlying incentives are badly asymmetric: Institutions can be blamed for harms caused by moving too fast, but almost no one is blamed when patients deteriorate during avoidable delays. One doctor called the emerging system “ritualized safety over actual risk assessment.” Or as, @DavidHongMD put it: "We often forget that the biggest risk is the cancer itself." - This problem is becoming more urgent because medicine itself is changing. Sequencing, biological engineering and A.I. make increasingly personalized therapies possible. But our regulatory system was mostly built for standardized drugs tested in large populations. - @sytse, the co-founder of GitLab, shows what personalized medicine can achieve: after relapsed osteosarcoma and being told there were no options left, he pursued a highly individualized approach and has now been cancer-free for a year. But doing so required extraordinary resources and regulatory expertise. - Pierce Ogden’s father was less lucky. After molecular analysis identified a drug that might target his glioblastoma, the manufacturer agreed to provide it. But administrative barriers delayed access until it was too late. “My dad was ready to try anything,” Pierce told me. “But the system is paternalistic.” - The A.I. revolution is making this bottleneck more important, not less. A.I. relies on relevant data. Information from early-stage trials could compound with A.I. tools to achieve truly revolutionary medicines. Without the data, this is far less likely to happen. - Another important shift is that innovation increasingly comes from academic labs and small biotech companies rather than Big Pharma. These small companies find it far harder to unable to absorb delays and regulatory barriers. - Apart from cancer, China is the biggest winner from America's outdated medical regulations. China has a much faster trial system, with testing often starting a full year earlier. This allows Chinese pharmaceutical companies to experiment and improve medicines while American companies play with mice. Today, half of all drugs licensed by major pharmaceutical companies originate there, up from less than 5 percent only a decade ago. - But we don't need to copy China. The best model is Australia: lots of on-site scientific and ethics reviews, and requirements that are proportionate to small, early-stage trials. Phase 1 studies there begin roughly 6–12 months faster, without any notable increases in adverse safety events. - Operation TrialBlazer, a 2026 HHS initiative is a good start in this direction, but we need legislative action by Congress to truly make Phase I trials faster and more efficient! I want to thank everyone who helped me with this article: everyone I interviewed and the amazing editors at the Times. This is the result of a months long journey of extensive interviews and research. Special thanks go to those who came on the record. One of the features of the system is an atmosphere of fear, where practitioners are afraid to publicly come out and explain these issues. So anyone who does is a hero in my book!
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Geeking out touring the Riken Fugaku supercomputer center with @MiraiTechCity as part of the @hausfund accelerator
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Absolutely exceptional. These people should be celebrated and supported. Fuck cancer.
People who cured / are curing their own cancer on X: 1/ @sytses - bone cancer, billionaire founder of Gitlab, developed 10+ personalized therapies for himself. 2/ @paul_conyngham - shrank his dog Rosie's mast cell cancer tumors after chemo and surgery weren't enough. Now backed by YC and Founders Fund 3/ @miriamgonp - stage 4 breast cancer, tumor sequenced, searching for vaccine manufacturer now 4/ @kevinace - stage 4 lung cancer, angel investor in 300+ companies, first drug stopped working after 18 months. Vaccine designed, now paying $300k out of pocket for the vaccine 5/ @masonbgrant: going founder mode on his his 32-year-old wife's rare liver cancer, sequencing her tumor with AI agents 6/ @ArunRLverma: former product leader at Atoms and Shopify, brain tumor, built a vaccine from his tumor. Now building an AI health agent startup based on what he went through We're going to make it
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