@VahidiLab

Assistant Professor @uofg | Biochemist | Structural Biologist | Mass spectrometry | NMR spectroscopy

 Guelph, ON, Canada
vahidilab.ca
Joined February 2020
  • Tweets732
  • Following419
  • Followers512
18Media
1/🧵Human ClpP protease is targeted in cancer therapy with the activator ONC201 @chimerix Yet all structures of ClpP have captured it in its inactive state, even when bound to activators! ClpP is paradoxically activated by inhibitors at low concentrations before inhibition starts
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Vahidi Lab@UofGuelph 🇨🇦 retweeted
Irina Bezsonova@IrinaBezsonovaOct 13
Please share: Hot off the press in NAR @OxfordJournals We solve the structure of the elusive “pixel” domain within human PML protein that looks like a nuclease but is not. Very proud of this collaboration with the Weller and Hao labs at UConnHealth. academic.oup.com/nar/article…

PXL: a nucleic acid-binding module of the promyelocytic leukemia protein

Abstract. The promyelocytic leukemia protein (PML) is a stress-response factor that assembles into PML nuclear bodies, dynamic subnuclear compartments invo

academic.oup.com
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Huge collaborative work with @OICR_news , @UHN_Research , and @NatalieZeytuni @McGill_ACB
ShorterLab@ShorterLabSep 28
Allosteric inhibition of human mitochondrial ClpP by hijacking the dordaviprone (ONC201) binding site: nature.com/articles/s41467-0…

Allosteric inhibition of human mitochondrial ClpP by hijacking the dordaviprone (ONC201) binding...

Nature Communications - ClpP is a mitochondrial protease and a validated cancer target. Here, the authors develop quinazolinone compounds that bind to the same site as the FDA-approved activator...

nature.com
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Vahidi Lab@UofGuelph 🇨🇦 retweeted
ShorterLab@ShorterLabSep 28
Allosteric inhibition of human mitochondrial ClpP by hijacking the dordaviprone (ONC201) binding site: nature.com/articles/s41467-0…

Allosteric inhibition of human mitochondrial ClpP by hijacking the dordaviprone (ONC201) binding...

Nature Communications - ClpP is a mitochondrial protease and a validated cancer target. Here, the authors develop quinazolinone compounds that bind to the same site as the FDA-approved activator...

nature.com
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Vahidi Lab@UofGuelph 🇨🇦 retweeted
University of Toronto@UofTAug 31
#UofT researcher Lewis Kay awarded 2026 Royal Medal by U.K.'s Royal Society 🏆 uoft.me/cCu
Image shows Lewis Kay

ALT Image shows Lewis Kay

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MCB at UofG@UofG_MCBAug 27
📢CONGRATULATIONS TO DR. MADISON TURNER on successfully defending her thesis on "Allosteric regulation of the Mycobacterium tuberculosis proteasome"👏👨‍🎓🥂🎉 🗓️August 20th 🔬Vahidi Lab
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MCB at UofG@UofG_MCBAug 27
📢CONGRATULATIONS TO DR. BRADLEY DAVIS on successfully defending his thesis on the "Substrate engagement mechanism of the bacterial proteasome activator Bpa"! 🎉👏🥳 🗓️August 13th 🔬Vahidi Lab
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Vahidi Lab@UofGuelph 🇨🇦 retweeted
MCB at UofG@UofG_MCBAug 27
📣CONGRATULATIONS TO DR. MONICA GONCALVES on successfully defending her thesis on "Mechanisms of allosteric regulation in human mitochondrial ClpP protease"!👏👏🍾🎉 🗓️August 25th 🔬Vahidi Lab
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The Hospital for Sick Children (SickKids)@SickKidsNewsAug 27
SickKids' Sr. Scientist Dr. Lewis Kay has received a prestigious 2026 Royal Medal from The Royal Society. In a new Q&A, Dr. Kay opens up about his journey, priorities and legacy ⬇️ sickkids.ca/en/news/archive/…

In conversation: Dr. Lewis Kay, molecular pioneer and catalyst for discovery

One of Canada's most distinguished scientists chats about his journey, his priorities and his legacy at SickKids and beyond.

sickkids.ca
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Vahidi Lab@UofGuelph 🇨🇦 retweeted
MCB at UofG@UofG_MCBAug 24
📣CONGRATULATIONS TO JACQUELYN OGATA-BEAN on successfully defending her thesis on "De novo design and characteri-589! of human mitochondrial ClpP activators"!👏👏🍾🎉 🗓️August 18th 🔬Vahidi Lab
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Rosenzweig Lab@lab_rosenzweigAug 23
After a while not posting, happy to share our latest paper on how the different J-domains interact with the various HSP70s! Proud of Roni and of the outcome🏆 @PNASNews pnas.org/doi/10.1073/pnas.25…

Human Hsp70 paralogs display selective J-domain interactions tuning proteostasis under stress | PNAS

Hsp70 chaperones are central regulators of proteostasis, mediating folding, refolding, degradation, and aggregation-prevention. Their activity is t...

pnas.org
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U of T News@UofTNewsAug 11
#UofT Professor Raquel Urtasun and John Rubinstein, senior scientist at @SickKidsNews and professor at @uoftmedicine, have been elected 2026 Fellows of the @royalsociety, the U.K.'s national academy of sciences uoft.me/czY

Raquel Urtasun and John Rubinstein elected fellows of U.K.'s Royal Society

Raquel Urtasun, professor of computer science in the University of Toronto's Faculty of Arts & Science, and John Rubinstein, senior scientist at the Hospital for Sick Children and a professor of...

utoronto.ca
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Vahidi Lab@UofGuelph 🇨🇦 retweeted
Journal of Biological Chemistry@jbiolchemJul 28
The ubiquitous biology of intracellular protein degradation: a tribute to Alfred L. (“Fred”) Goldberg. The review articles in this series highlight key areas shaped and inspired by his enduring contributions. jbc.org/thematic-the-ubiquit…
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Magnetic Resonance News@nmr900Jun 9
Researchers at the University of Guelph & University of Toronto, led by Siavash Vahidi @VahidiLab and Lewis E. Kay @LEK_Lab together with Waters Corp, used NMR to identify a potential drug target in the tuberculosis stress-response system news.uoguelph.ca/2026/06/u-o… #NMRchat #NMR 🧲

U of G Researchers Identify Potential Drug Target in Tuberculosis Stress-Response System

Tuberculosis is one of the world’s deadliest infectious diseases, killing more than a million people every year. Part of what makes the bacterium that causes the disease so difficult to eliminate is…

news.uoguelph.ca
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MCB at UofG@UofG_MCBMay 13
CONGRATULATIONS to our Phillips Scholarship Winners, Nicholas Gervais (Shapiro Lab) and Bradley Davis (Vahidi Lab)!!👏👏👏🎉🥳🎈
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Konermann Lab@KonermannLabMar 19
Can enzymes retain catalytic activity in the gas phase? Using tandem MS, molecular dynamics simulations, and enzyme variants courtesy of the @VahidiLab, Kirsty (@kirstynyk) uncovers new insight towards this question. Now published in JACS (@J_A_C_S)! pubs.acs.org/doi/10.1021/jac…

Catalytic Activity of Electrosprayed Enzyme Ions in the Gas Phase

Abstract. Most enzyme reactions occur in aqueous solution, but catalytic activity is often retained in nonaqueous solvents. It is an intriguing question wh

pubs.acs.org
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Carolina Tropini, PhD@CTropiniFeb 13
CIHR funding rate: 13.6%. Early 2000s: 30%+. Canada’s new $1.7B Impact+ program recruits talent — but without increased Tri-Council base funding, we risk further strain on an already stretched system. We’re calling for $1B over 5 years. Support here: tinyurl.com/33c5av46

Letter to Canadian Government to Increase Research Funding - 202602

Update 05/26/2026 Dear colleagues, A quick update, we received a response from Minister Mélanie Joly regarding the letter many of you signed on research funding and the Impact+ initiative, conversa...

docs.google.com
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Dougan Lab@DouganLabFeb 9
Molecular mechanisms of mitochondrial AAA+ proteases - Journal of Biological Chemistry jbc.org/article/S0021-9258%2…

Molecular mechanisms of mitochondrial AAA+ proteases

Mitochondrial AAA+ proteases, LONP1, ClpXP, YME1L (i-AAA), and the m-AAA complex, maintain protein quality and shape organelle function. Growing interest in these enzymes stems from their association...

jbc.org
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Biophysical Society@BiophysicalSocJan 29
Join 2026 BPS Lecturer Lewis Kay on Tuesday, February 24, 2:00 PM - 3:00 PM at #bps2026 for an informal discussion. Dr. Kay will share insights from his scientific career—from pioneering discoveries to lessons learned along the way—and reflect on how the field continues to evolve
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Cezar Khursigara@CMKhursigara26 Aug 2025
MCB @ U of Guelph is hiring (again)! 🎉 Tenure-track Assistant Professor in Biochemistry Part of our strategic cluster hire. Apply now 👉 careers.uoguelph.ca/job/Guel… #Biochemistry #FacultyJobs #AcademicTwitter #MolBio

Assistant Professor (Biochemistry)

Assistant Professor (Biochemistry)

careers.uoguelph.ca
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Irina Bezsonova@IrinaBezsonova22 May 2025
Out in @pnas today Showcasing the power of NMR! NMR and enzyme kinetics show USP7 enzyme transiently sampling a low-populated active state, and its disease-causing variant enhancing these dynamics pnas.org/doi/10.1073/pnas.24… Stellar work by students Gabi Valles and Emilie Korchak

Activation dynamics of ubiquitin-specific protease 7 | PNAS

Ubiquitin-specific protease 7 (USP7) is a deubiquitinating enzyme that plays a crucial role in cellular processes, including the maintenance of gen...

pnas.org
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