Chemical biology postdoc fellow in @HMS_BCMP. Former therapeutics PhD student in Nathanael Gray's lab with @chemical_phd + @DFCI_ChemBio.
Joined July 2018
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Congrats to Eddie and team!
Here we report the in silico discovery of functional MRGPRX2 antagonist nanobodies using AlphaFold2-Multimer. Thanks for the collaboration @katherine_susa @JSmithMDPhD
Chelsea Powell retweeted
Our paper is online now!!!! @StJudeResearch @postech2020 @ShanghaiTechUni Glut3 obstructs tumor immune surveillance by enhancing O-GlcNAcylation of cellular proteins in tumor-infiltrating Tregs.
nature.com/articles/s41423-0…
Chelsea Powell retweeted
One of my newest adventures - hosting a podcast!
If you are keen on chemical biology, medicinal chemistry, chemical probes, tool compounds, degraders, chemoproteomic tools, and more... tune to @Target2035 podcasts. Pilot episode is out... more to come!
podcasters.spotify.com/pod/s…
Chelsea Powell retweeted
We are hiring! Looking for a #postdoc to join the team in the Nowak Lab to focus on chemical biology in cells and recombinant systems. Excited about protein degradation, small molecule proximity? get in touch!
#TPD #InducedProximity #ChemicalBiology
nowak-lab.com/
Chelsea Powell retweeted
Excited to share that our work is online @cellhostmicrobe A small intestinal bile acid, taurodeoxycholic acid, is increased after sleeve gastrectomy and decreased in diabetic patients. It improves host metabolism by inhibiting the bacterial production of lithocholic acid.
Check out our new paper published @cellhostmicrobe! Lithocholic acid (LCA) is a metabolic toxin decreased by bariatric surgery. Taurodeoxycholic acid, which is increased by surgery, inhibits LCA production by microbes and has metabolic benefits.
authors.elsevier.com/a/1jTSj……
Chelsea Powell retweeted
Excited to share E3-substrate tagging by ubiquitin biotinylation (E-STUB) @nchembio! E-STUB enables CUL-RING ligase substrate identification and may transform the way we study glues and PROTACs by directly studying substrate ubiquitylation. 1/
rdcu.be/dBZKx
Chelsea Powell retweeted
Are you interested in strategies to control the spatial localization of your favorite protein at will? In our review, @Saurav054 and I discuss the exciting development of chemical inducers of proximity to control subcellular protein localization. authors.elsevier.com/a/1ikNC…
Congratulations, Radek!! If you are looking for postdoc and tech positions please consider the Nowak Lab. Radek is an amazing person to work with!
NEWS! I'm excited to share that I'm joining @IsbBonn @UniklinikBonn @UniBonn @ImmunoSens as a professor to start my LAB! We are open for business and #hiring for #postdoc #tech positions! #NewPI #MoveToGermany #UniBonn #TPD #InducedProximity Please share! nowak-lab.com
Chelsea Powell retweeted
So proud to share my lab’s first PROTAC in @ChemBioChem #ChemBioTalents! In work led by @ErikoKoide & Kaela Mohardt, we developed a selective in vivo-compatible FAK inhibitor and PROTAC with exciting activity in pancreatic cancer models. A few highlights:
dx.doi.org/10.1002/cbic.2023…
Chelsea Powell retweeted
Pls circulate! If anyone is interested in doing a postdoc in how the gut microbiome modulates metabolic disease, look no further than Dr. Snehal Chaudhari’s new lab @UWBiochem. Snehal is a FANTASTIC scientist and mentor so I highly recommend checking out her lab ☺️
Amazing work, @ZHauseman!! Congrats!
I’m excited to share that my (official and formatted!) paper has been published in @Nature. The manuscript is centered around a high-resolution structure of a key protein complex for activation of the MAPK pathway- the MRAS-SHOC2-PP1C holophosphatase.
nature.com/articles/s41586-0…
Chelsea Powell retweeted
The Nabet lab @fredhutch is hiring! We are seeking a curious and highly motivated Research Technician to join our growing team and have exciting projects aimed at advancing new targeted protein degradation technologies. Please RT and apply here:
careers-fhcrc.icims.com/jobs…
Our paper "Selective Macrocyclic Inhibitors of DYRK1A/B" is out now in @ACSMedChemLett. Great to work on this med chem story with John Hatcher and team @DFCI_ChemBio. pubs.acs.org/doi/10.1021/acs…
Great work, @miniboe!!
New paper online! cell.com/cell-host-microbe/f… (collaboration with Jun Huh's lab) describing how bacteria biosynthesize the bile acid metabolite isoalloLCA and how this molecule induces the development of regulatory T cells, and featuring lead co-authors @miniboe and @saiyu_hang (1/2)
Glad to see our story on selective degradation-inducing probes for studying cereblon (CRBN) biology out now in @rsc_medchem! Great to work with @GuangyanD, @JWBushman93, and the rest of the team at @DFCI_ChemBio.
doi.org/10.1039/D0MD00382D
Chelsea Powell retweeted
Chemistry + Biology = Chemical Biology??? You decide @chemical_phd (ft. @CRISPRCream)
It was really fun to chat about research during COVID with @miniboe!
Chelsea Powell-postdoc at Harvard Medical School-discusses her experience transitioning into a new job right before the shutdown and shares important tips for incoming grad students.
Recorded: 5 November 2020
Featuring: Wei Li, Chelsea Powell
#scicomm
open.spotify.com/episode/4hB…
Chelsea Powell retweeted
It is season for @girlscouts cookies - for all of you in the US it's time to stock up on ThinMints and support some awesome girls. My girl made this poster to illustrate what girl scouts mean to her. Please RT and add to her order if you can: app.abcsmartcookies.com/#/so…
Chelsea Powell retweeted
We are looking for a Lab Manager to join us in the awesome Fischer Lab team at Dana-Farber Cancer Institute.
If you or anyone you know might be interested, please apply directly at the link below or reach out to me with any questions.
Please RT!
careers.dana-farber.org/job/…
Amazing work from Snehal and team!
It's an exciting week for the Devlin Lab! Check out our latest paper in @cellhostmicrobe featuring lead author Snehal and in collaboration with the Sheu lab @BrighamSurgery and the Huh lab @HMS_Immunology!