Chemical biology postdoc fellow in @HMS_BCMP. Former therapeutics PhD student in Nathanael Gray's lab with @chemical_phd + @DFCI_ChemBio.
Joined July 2018
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Chelsea Powell retweeted
Our paper is online now!!!! @StJudeResearch @postech2020 @ShanghaiTechUni Glut3 obstructs tumor immune surveillance by enhancing O-GlcNAcylation of cellular proteins in tumor-infiltrating Tregs.
nature.com/articles/s41423-0…
Chelsea Powell retweeted
One of my newest adventures - hosting a podcast!
If you are keen on chemical biology, medicinal chemistry, chemical probes, tool compounds, degraders, chemoproteomic tools, and more... tune to @Target2035 podcasts. Pilot episode is out... more to come!
podcasters.spotify.com/pod/s…
Chelsea Powell retweeted
We are hiring! Looking for a #postdoc to join the team in the Nowak Lab to focus on chemical biology in cells and recombinant systems. Excited about protein degradation, small molecule proximity? get in touch!
#TPD #InducedProximity #ChemicalBiology
nowak-lab.com/
Chelsea Powell retweeted
Excited to share that our work is online @cellhostmicrobe A small intestinal bile acid, taurodeoxycholic acid, is increased after sleeve gastrectomy and decreased in diabetic patients. It improves host metabolism by inhibiting the bacterial production of lithocholic acid.
Check out our new paper published @cellhostmicrobe! Lithocholic acid (LCA) is a metabolic toxin decreased by bariatric surgery. Taurodeoxycholic acid, which is increased by surgery, inhibits LCA production by microbes and has metabolic benefits.
authors.elsevier.com/a/1jTSj……
Chelsea Powell retweeted
Excited to share E3-substrate tagging by ubiquitin biotinylation (E-STUB) @nchembio! E-STUB enables CUL-RING ligase substrate identification and may transform the way we study glues and PROTACs by directly studying substrate ubiquitylation. 1/
rdcu.be/dBZKx
Chelsea Powell retweeted
Are you interested in strategies to control the spatial localization of your favorite protein at will? In our review, @Saurav054 and I discuss the exciting development of chemical inducers of proximity to control subcellular protein localization. authors.elsevier.com/a/1ikNC…
Chelsea Powell retweeted
So proud to share my lab’s first PROTAC in @ChemBioChem #ChemBioTalents! In work led by @ErikoKoide & Kaela Mohardt, we developed a selective in vivo-compatible FAK inhibitor and PROTAC with exciting activity in pancreatic cancer models. A few highlights:
dx.doi.org/10.1002/cbic.2023…
Chelsea Powell retweeted
Pls circulate! If anyone is interested in doing a postdoc in how the gut microbiome modulates metabolic disease, look no further than Dr. Snehal Chaudhari’s new lab @UWBiochem. Snehal is a FANTASTIC scientist and mentor so I highly recommend checking out her lab ☺️
Chelsea Powell retweeted
The Nabet lab @fredhutch is hiring! We are seeking a curious and highly motivated Research Technician to join our growing team and have exciting projects aimed at advancing new targeted protein degradation technologies. Please RT and apply here:
careers-fhcrc.icims.com/jobs…
Chelsea Powell retweeted
Chemistry + Biology = Chemical Biology??? You decide @chemical_phd (ft. @CRISPRCream)
Chelsea Powell retweeted
It is season for @girlscouts cookies - for all of you in the US it's time to stock up on ThinMints and support some awesome girls. My girl made this poster to illustrate what girl scouts mean to her. Please RT and add to her order if you can: app.abcsmartcookies.com/#/so…
Chelsea Powell retweeted
We are looking for a Lab Manager to join us in the awesome Fischer Lab team at Dana-Farber Cancer Institute.
If you or anyone you know might be interested, please apply directly at the link below or reach out to me with any questions.
Please RT!
careers.dana-farber.org/job/…
Chelsea Powell retweeted
We are looking for a talented biochemist with excellent organisational skills to join us for the cutting edge technology development at the Center for Protein Degradation. Please RT!
#degraders #TargetedProteinDegradation
careers.dana-farber.org/job/…
Chelsea Powell retweeted
Very insightful study by @DFCI_ChemBio about reprogramming lenalidomide: it only takes a small library of IMiD glues screened against a matched pair of cells to identify a selective GSPT1 degrader. The SAR is steep but can be rationalized. @ACSBioMed pubs.acs.org/doi/10.1021/acs…
Chelsea Powell retweeted
Happy to share a preprint of our method to assess whether E3 ligase components can be redirected for targeted protein degradation: Covalent Functionalization Followed by E3 Electroporation (COFFEE)!
A Strategy to Assess the Cellular Activity of E3 Ligases against Neo-Substrates using Electrophilic Probes biorxiv.org/cgi/content/shor… #bioRxiv
Chelsea Powell retweeted
Medicinal chemists have long sought a pharmaceutical alternative to bariatric surgery to treat type II diabetes and researchers have now identified cholic acid-7-sulfate (CA7S) as a possible candidate. Check out the work that led to this finding: ow.ly/C7AU50ASVsW
Chelsea Powell retweeted
A new paper from @DevlinLab and colleagues found that levels of the endogenous bile acid CA7S increase in mouse and human GI tract after sleeve gastrectomy. CA7S acts through the GPCR TGR5 to increase glucose tolerance. nature.com/articles/s41589-0…
Chelsea Powell retweeted
BOSTON/CAMBRIDGE! I’m looking for people with cars in the area that are willing to go grocery shopping and delivering items for families going through food insecurity! We have the money to buy the food. We just need the delivery (instacart has too many fees). DM me if interested!
Chelsea Powell retweeted
Meet freshly minted Harvard Ph.D., Dr. Bruce Hua. Bruce earned his degree by executing on his brilliant insights into organic synthesis and chemical biology. What emerged was a doctoral thesis for the ages. Bravo!
Chelsea Powell retweeted
Harvey et al. and Loren Walensky @DanaFarber perform a disulfide tethering screen of BFL-1, a BCL-2 protein implicated in cancer, and identify molecules capable of covalently targeting a unique C55-residue of the anti-apoptotic groove. bit.ly/2T8Zfr0
