Working to extend healthy human life |@age1VC | đ§đ·đșđž
San Francisco, CA
Joined June 2014
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Carol retweeted
đźAnnouncing the Lantern Summit in Shanghaiđź
In 2025, more new medicines launched first in China than anywhere else on Earth.
That has never happened before.
Drug development has two simultaneous accelerators:
âąâ â AI is collapsing design (weeks instead of years).
âąâ â China is collapsing development (physical iteration speed).
Here is why that matters, and what Western biotech is missing: đ§”
My entire feed today: the complex phenomenon of hot girls in SF and the emerging crisis of novocaine masculinity. August has got to be a slow news cycle.
Evidence of cellular age reversal â evidence of physiological age reversal
And this is an important distinction!
You keep proclaiming you have the 1st FDA approved clinical trial of age reversal. That's false.
The language by the FDA to @lifebiosciences was to clear a Phase 1 clinical trial testing ER-100 in people with certain optic-nerve diseases. Nothing about reversing age.
Any changes observed for the individuals in the trial for their eye disease is not the same as reversing age.
You can say it's the first human trial of partial epigenetic reprogramming, but apparently that's not enough for you.
Carol retweeted
1/ Today, @Primero_ai is announcing its public launch and a $12m seed, one of the largest seed rounds in LatAm.
Primero is the AI transformation company for Latin America's largest enterprises.
I canât believe Claude doesnât have an index where I can see all the questions Iâve asked in a thread and jump between them easily. All the Chrome extensions I can find are terrible too, so I'm just endlessly scrolling.
Rlly wishing I could have watched the Spain game. Helping me feel slightly better about the Brazil and Morocco 1-1
Iâm fascinated by the psychology of people who operate at top-level, competitive, high-pressure environments.
Rory McIlroy is such an interesting example of insane resilience. Wins his first major at 22. Goes 10 years without a major. Loses the masters 15 times (with a crazy amount of pressure for a grand slam) until he finally gets it in 2025 and then again this year.
Thereâs a prime documentary where he talks through each hole in the final round and itâs so interesting to hear what was going through his head!
Carol retweeted
You have no experience.
Youâve never started a company.
Youâve never had a full time job.
Nike is going to kill you.
Youâre a kid.
You donât have technical skills.
You shouldnât build hardware.
Apple is going to kill you.
You canât build hardware.
You canât measure heart rate non-invasively.
Athletes donât care about recovery.
Under Armour is going to kill you.
It wonât be accurate.
You donât listen.
Youâre an ineffective leader.
You canât recruit great talent.
Youâre going to have to pay every athlete.
You canât measure sleep non-invasively.
Itâs too expensive to research.
Athletes are a small market.
The product costs too much to make.
The product costs too much to sell.
Your valuation is too high.
Consumers arenât going to want it.
Hardware is too hard.
You should measure steps.
Fitbit is going to kill you.
You canât build a marketing engine.
You canât raise enough money.
You need a real CEO.
Google is going to kill you.
You canât be a subscription.
You canât build a brand.
You canât do consumer in Boston.
Your valuation is too high.
You shouldnât make accessories.
You shouldnât make apparel.
Lululemon is going to kill you.
You canât predict Covid.
Stay in your niche.
You are going to run out of money.
You canât build a health platform.
Amazon is going to kill you.
You canât measure blood pressure.
You canât get medical approvals.
The market is too small.
You donât understand AI.
The market is too competitive.
It wonât work internationally.
The supply chain is too complicated.
You canât build an AI.
You canât raise enough money.
Itâs too competitive.
Healthcare isnât going to want it.
âŠ
Just keep going âïž
Carol retweeted
After a long hiatus, I'm back to writing - starting with a very topical piece.
Why are colorectal cancer rates spiking in the young?
The usual answers are true: changes in diet, exercise, environment.
But there's also a much more direct player involved
Carol retweeted
Approved episode #2 out now: Geron
They trailblazed longevity biotech in the '90s, cloned telomerase, funded early hESC work - and after 34 years got the first telomerase inhibitor approved for a rare blood cancer.
Full story on the pod.
Great work!
Finding new medicines is getting more and more expensive, and AI won't help much unless we can generate physiological data at scale.
In our new preprint, @GordianBio extends the progress of the functional genomics community to run pooled in vivo screens at scale, in a way that answers questions about physiology and therapeutic potential.
We show screens in mice and horses, fibrotic and degenerative disease, with a framework for physiological predictions validated in human ex vivo tissues.
Very proud of @v_sontake, @vkartha88, Neety and the rest of the team. Tweetorial follows:
Carol retweeted
AGI timelines are accelerating dramatically. The promise of many working in the field is the ultimate health impact to humanity including cures to cancer and significantly increasing healthy lifespan. But how? Join the first Summit on the Convergence of AI and Longevity!
If your bf isnât getting fashion advice from Claude, what is he even doing? (Context buying a black suit)
