Metabolic Biochemist. Interested in problems that intersect analytical chemistry, metabolism, toxicology, and the environment. 🇺🇸 in 🇱🇺
Esch-sur-Alzette, Luxembourg
Joined December 2016
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#MetaboliteRepair enzymes have evolved to eliminate often toxic non-canonical metabolites. Out today in @nchembio, we found that CLYBL repairs malyl-CoA, a TCA cycle side-product, to avert vitamin B12 depletion doi.org/10.1038/s41589-025-0…
Happy to share this preprint of my postdoc work on discovering that CLYBL repairs malyl-CoA to avert methylmalonyl-CoA mutase inhibition and loss of vitamin B12! Thanks to the team for all your help! #MetaboliteRepair
biorxiv.org/content/10.1101/…
Looking forward to this afternoon's session on "Enzymatic control of problematic intermediates" at #DiscoverBMB! Three metabolite repair talks in a session - this may be a record!
Corey Griffith retweeted
(Nature MS) A spectroscopic test suggests that fragment ion structure annotations in MS/MS libraries are frequently incorrect dlvr.it/T2lZ8j (RSS) #nature #MassSpecRSS
Corey Griffith retweeted
The TCA cycle is fraught with metabolite damage. Here we describe a universal repair enzyme that prevents the TCA cycle from poisoning itself:
link.springer.com/10.1038/s4…
Corey Griffith retweeted
Zebrafish model for CLN3 Batten disease recapitulates the human metabolic signatures of BMP depletion and accumulation of glycerophosphodiesters and cholesteryl esters at larval stages life-science-alliance.org/co…
Corey Griffith retweeted
biorxiv.org/content/10.1101/…
Nice follow up by @mdtauqeer on his earlier work on enzyme inhibition doi.org/10.1038/ncomms16018, now showing how frequent metabolic enzyme activators let metabolic pathways talk to each other
So very proud of my friend and colleague, Lorenzo! Congratulations! 🥳
Congratulations to Dr. Lorenzo Favilli - second ECI and ECHIDNA PhD graduate. We are all so proud of you!
#proudPI #metabolomics #TeamMassSpec @lcsb_uni_lu @uni_lu @FnrLux @ResearchLux
Here with Carole Linster and @coreymgriffith
Many thanks to our Jury & audience as well!
Congrats on the promotion @ESchymanski!! 🎉🥳
What a great team!
#environmental #cheminformatics @lcsb_uni_lu
@EmmaPalm4 @DagnyAurich Federica Vero @HibaMohamedTaha @AnjuAnjuraj15 @Begotalavera9 Camilla @PChirsir Lorenzo @coreymgriffith (out of pic @GianfrancoFrig1 )
Corey Griffith retweeted
What a great team!
#environmental #cheminformatics @lcsb_uni_lu
@EmmaPalm4 @DagnyAurich Federica Vero @HibaMohamedTaha @AnjuAnjuraj15 @Begotalavera9 Camilla @PChirsir Lorenzo @coreymgriffith (out of pic @GianfrancoFrig1 )
Corey Griffith retweeted
Interested in rare diseases, mitochondria, non-target mass spectrometry #TeamMassSpec #cheminformatics and identification?
Exciting #postdocposition in GENOMIT consortium with rare disease cohort at @lcsb_uni_lu @uni_lu in the Linster & Schymanski groups!
emea3.mrted.ly/3fyae
Corey Griffith retweeted
Come join us!
We are looking for a Postdoctoral Researcher in Mass Spectrometry Workflows for Unknown Chemicals to join the Environmental Cheminformatics group at @lcsb_uni_lu @uni_lu
#TeamMassSpec #cheminformatics #OpenScience
Interested? Apply here⬇️
emea3.mrted.ly/3h2lg
Corey Griffith retweeted
High-throughput Saccharomyces cerevisiae cultivation method for credentialing-based untargeted #metabolomics
by Lorenzo Favilli et al @lcsb_uni_lu @uni_lu @ESchymanski @coreymgriffith #yeast #chromatography #labelling #spectrometry
#OpenAccess
link.springer.com/article/10…
Corey Griffith retweeted
A real @fonia_sin led by our coordinator @PabloINik ! In front of the Opera House in the eternal city, in the occasion of our final meeting, but is it so? I doubt it 😎 we will continue playing 🙌🏻
Corey Griffith retweeted
Come be a split EM/ECI postdoc like me! This is a very cool project for those interested in unknown identification.
If you are interested in a PostDoc for targeted and untargeted #metabolomics #TeamMassSpec for mitochondrial disorders working with these two groups at @lcsb_uni_lu @uni_lu funded by @FnrLux as part of the GENOMIT consortium, please apply here:
emea3.mrted.ly/3dsa5
Pass this immediately!
NEW: I’m proposing the 28th Amendment to the United States Constitution to help end our nation’s gun violence crisis.
The American people are sick of Congress’ inaction.
The 28th will enshrine 4 widely supported gun safety freedoms -- while leaving the 2nd Amendment intact:
1) Raising the minimum age to purchase a gun to 21
2) Universal background checks
3) A reasonable waiting period for gun purchases
4) Banning the civilian purchase of assault weapons
Corey Griffith retweeted
Thank you very much @ESchymanski @coreymgriffith Lorenzo and Carole for submitting your work to ABC!
@GNPS_UCSD @lcsb_uni_lu @uni_lu @FnrLux #metabolomics
Super #proudPI tonight to see Lorenzo's work with Carole Linster and @coreymgriffith now published - high throughput stable labeling approach for untargeted metabolomics in yeast, all data in @GNPS_UCSD and more!
@lcsb_uni_lu @uni_lu @FnrLux #OpenScience
link.springer.com/article/10…
Many congrats to Lorenzo and the entire team! Credentialing is a powerful yet unexploited branch of metabolomics and herein, we devised a nice approach to help tackle these projects in yeast.
Super #proudPI tonight to see Lorenzo's work with Carole Linster and @coreymgriffith now published - high throughput stable labeling approach for untargeted metabolomics in yeast, all data in @GNPS_UCSD and more!
@lcsb_uni_lu @uni_lu @FnrLux #OpenScience
link.springer.com/article/10…
Corey Griffith retweeted
We are looking for a PhD candidate who is enthusiastic about discovering the function of enzymes and metabolites in Mycobacterium tuberculosis using genetic screens and untargeted metabolomics.
Interested? Please apply before May 26th!
ru.nl/en/working-at/job-oppo…
#jebentnodig
Come be a split EM/ECI postdoc like me! This is a very cool project for those interested in unknown identification.
If you are interested in a PostDoc for targeted and untargeted #metabolomics #TeamMassSpec for mitochondrial disorders working with these two groups at @lcsb_uni_lu @uni_lu funded by @FnrLux as part of the GENOMIT consortium, please apply here:
emea3.mrted.ly/3dsa5