The Physics of Life and Quantitative Biology Fellow at Sheffield Uni. Interdisciplinary Biophysics on Chromatin organising machines. Views are my own.
Joined January 2019
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Dr. Erin E. Cutts 👩🔬 retweeted
🚨We’re hiring!
Passionate about #microscopy, #biophysics and #interdisciplinaryresearch? There's still time to apply for our EPSRC PhD project on how actin network architecture shapes the mechanical properties of cells at @sheffielduni
Learn more/Apply: findaphd.com/phds/project/fo…
Dr. Erin E. Cutts 👩🔬 retweeted
The study of KIF4A-mediated human condensin I activation is out! Congrats to @cutts_dr, L. Aragon, @DamlaTetiker !
Chromokinesin KIF4A activation of human condensin I involves a SLiM interfering with auto-inhibitory intramolecular interactions within condensin, exemplifying a conserved mechanism for regulating diverse SMC complexes
@cutts_dr, Luis Aragon et al
embopress.org/doi/full/10.10…
Dr. Erin E. Cutts 👩🔬 retweeted
Our work on SMC Wadjet complex is finally out @MolecularCell ! Congrats to @BisLightyear @iamamardeeep @_KevinCorbett & co.!
Online Now: Loop-extrusion-mediated plasmid DNA cleavage by the bacterial SMC Wadjet complex dlvr.it/TGXdm1
Dr. Erin E. Cutts 👩🔬 retweeted
The short talk abstract deadline for the Keystone Interplay of Chromatin Architecture and Transcription Regulation meeting is coming up (Jan 9). The meeting is being held jointly with the Epigenetics in Development and Disease meeting, and it will be awesome! #KSChromatin25
Dr. Erin E. Cutts 👩🔬 retweeted
“We’re very excited to see what people do with this”
AlphaFold3 is open at last go.nature.com/4fHAfio
Dr. Erin E. Cutts 👩🔬 retweeted
Excited to share that the AlphaFold 3 model code and weights are now available for academic use.
Looking forward to seeing what new research this unlocks and how the research community builds on AlphaFold 3 for scientific discoveries github.com/google-deepmind/a… 1/2
Dr. Erin E. Cutts 👩🔬 retweeted
A quantitative intracellular peptide binding assay reveals recognition determinants and context dependence of short linear motifs biorxiv.org/cgi/content/shor… #biorxiv_biochem
Dr. Erin E. Cutts 👩🔬 retweeted
Very proud of @BoyaZhang4 and this lovely first paper, first of many I am sure.
My first author paper is now online in @OpticaWorldwide ! Please allow me introduce Vortex Light Field Microscopy: a simple and efficient way of achieving 3D spectral single-molecule imaging. Comments and feedbacks are welcome!
@CamMicroscopy @PDN_Cambridge @Cambridge_Uni
Dr. Erin E. Cutts 👩🔬 retweeted
🔥JOB ADVERT🔥
Looking for a postdoc to work on #machine_learning classification of #knots & #proteins and discovery of new topological invariants.
Start by November 2025
Duration 2 years min
Where: TAPLab @PhysAstroEd
Generously funded by @LeverhulmeTrust
Retweet pls ❤️
Dr. Erin E. Cutts 👩🔬 retweeted
Exciting! Meeting all my colleagues working on SMC complexes in Numazo Japan: niki-lab.sakura.ne.jp/NIGIS2…
Dr. Erin E. Cutts 👩🔬 retweeted
New work from the lab!
James Stowell led this project showing the importance of multivalency and phospho-regulation in mRNA decay. This has many parallels with other mechanisms in gene expression... 🧵 1/
#RNA #NMR #bioRxiv @MRC_LMB @ERC_Research
Dr. Erin E. Cutts 👩🔬 retweeted
I am super excited to show our work, now published in NAR @NAR_Open, on the structural function of SLF1 at the stalled replication fork. @AstburyCentre @ScienceLeeds academic.oup.com/nar/article…
Dr. Erin E. Cutts 👩🔬 retweeted
The opacity of academic prose arises from the epistemological imperative to operationalize disciplinary jargon, facilitating intra-specialized discourse while obfuscating heterogenous interpretive accessibility and perpetuating a recursive dialectic of erudition and exclusion.
Dr. Erin E. Cutts 👩🔬 retweeted
Preprint just dropped!🎙️We discover molecular mechanisms of the excruciatingly painful sting of the Scarlet Velvet Ant (Dasymutilla occidentalis). Title: "Multiple mechanisms of action of an extremely painful venom." 🧵 1/N biorxiv.org/content/10.1101/…
Dr. Erin E. Cutts 👩🔬 retweeted
Happy to share our recent work on symmetry of loop extrusion by SMC complexes! The work from @BisLightyear @Ekimlab
biorxiv.org/content/10.1101/…
Dr. Erin E. Cutts 👩🔬 retweeted
🔈Our last paper on DNA elasticity and A-tracts has just appeared in Nanoscale: doi.org/10.1039/D4NR02571G. Simulations and analysis done by @TaniaGardasevic during her masters and @PhysicsofLifeUK summer studentship (so talented!🤯)
Dr. Erin E. Cutts 👩🔬 retweeted
Excited to share our work showing how PLK1 licenses CENP-A deposition at centromeres to ensure centromere inheritance @WTcell @GeneCenter_LMU @SBSatEd @LMU_Muenchen @Pragya_Sriv @bethan_medina @Alba_Edinburgh @PaulaSoteloP @ERC_Research @wellcome & MRC science.org/doi/10.1126/scie…
Dr. Erin E. Cutts 👩🔬 retweeted
🚨📣 Excited to share our latest work investigating how the replisome responds to topoisomerase-DNA crosslinks 🧬🔬
cell.com/molecular-cell/full…
Fantastic work from @rosewesthorpe and @JohannJRoske 🍄🍄🍄🍄
Dr. Erin E. Cutts 👩🔬 retweeted
Excited to share the revised version with a new title "CDCA7 is an evolutionarily conserved hemimethylated DNA sensor in eukaryotes"
now published @ScienceAdvances!
Congrats @IsabelWassing, @QingyuanJia, @NishiyamaAtsuya, @KyoheiArita!
science.org/doi/10.1126/scia…
New preprint from the lab led my talented postdoc @IsabelWassing!
She discovered that CDCA7's unique zf-4CXXC_R1 domain acts as a novel hemi-methylated DNA binding module to recruit the nucleosome remodeler HELLS and help DNA methylation! Check out her tutorial!
Dr. Erin E. Cutts 👩🔬 retweeted
My first paper from my post-doc is now out in @MolecularCell
SWR1 exchanges H2A/H2B dimers in a nucleosome for Htz1/H2B dimers in a stepwise manner. Here, we report the structural basis for the intermediate steps of SWR1-mediated histone exchange:
dlvr.it/TCjWZl