Endocrinologist | Diabetologist | Cardiovascular Prevention | Cricket enthusiast | Hiker
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Joined January 2014
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Alhamdulillah! 🎓
Delighted to celebrate completion of PhD from the University of Manchester.
A heartfelt thank you to everyone who supported, encouraged and guided me throughout this journey, my supervisors, mentors, colleagues, friends and, above all, my family. – at Manchester, England
Thanks to @heartukcharity for invitation to deliver plenary lecture. Our UK CPRD data show that hyperTG is not a uniform CV risk factor but impact varies across vascular beds and patient populations, highlighting the need for precise cardiovascular risk stratification.
Bilal Bashir retweeted
New data presented by Dr Bilal Bashir explored the relationship between hypertriglyceridaemia and cardiovascular risk using the UK CPRD database.
Key takeaways:
• Hypertriglyceridaemia was associated with increased cardiovascular risk, but the pattern differed between primary and secondary prevention.
• Risk also varied across different vascular territories, highlighting that triglyceride-related risk is not uniform.
• The findings support the need for population-specific and vascular territory-specific risk assessment, moving beyond LDL-C alone.
An interesting reminder that addressing residual cardiovascular risk remains an important challenge.
#HEARTUK #Lipids #CardiovascularDisease #Triglycerides
Delighted to present 4 abstracts at #EASCongress from the Lipoprotein Research Group at @MFTnhs including research on TG and CVD, the global FCS registry & the publication of interim HEART-2 PCSK9 gene-editing data in @NEJM led by @ScottVafai and an outstanding international team
Bilal Bashir retweeted
Be PRAGMATIC
Be SIMPLE
From Haffner to VESALIUS: we didn’t discover anything new… we finally accepted it.
📍 1888, Haffner (NEJM) already warned us:
👉 A patient with diabetes and no MI carries a risk similar to someone who already had one.
nejm.org/doi/full/10.1056/NE…
📍 2026 VESALIUS (JAMA) just removes the last excuse:
👉 Even before clinically evident atherosclerosis, the risk is already biologically active.
jamanetwork.com/journals/jam…
👆 Let’s be honest:
There are NO LOW-RISK patients with diabetes
There are NO INTERMEDIATE-RISK patients with diabetes
👉 There are only:
HIGH RISK
VERY HIGH RISK (most of them, if you actually look closely)
📌 The problem is not classification.
📌 The problem is clinical denial and therapeutic inertia.
We don’t undertreat diabetes because we lack evidence.
👉 We undertreat it because we are still thinking in outdated risk categories.
Atherosclerosis starts early.
Diabetes accelerates it.
And we… keep labeling instead of acting.
@society_eas
@nationallipid
The genetic architecture of FCS is more complex and heterogeneous in the UK:
- 12.9% of the tested are genetically confirmed FCS
- Over half are LPL-FCS, but non-LPL FCS are equally common
- Regional & ethnic variability
gimopen.org/article/S2949-77…
@RareDiseases @heartukcharity
Neurodegeneration, neuropathy & familial chylomicronemia syndrome (FCS) — we report an under-recognised complication of this rare lipid disorder.
share.google/wfDNNMUE5DlovAK… – at Cottam, England
Our latest work shows that hypertriglyceridaemia alone can cause small fibre neuropathy and cardiac autonomic dysfunction.
doi.org/10.1016/j.atheroscle…
@MFT_MRI @MFTnhs @heartukcharity
We reviewed how does HDL participate in atherogenesis? Antioxidant Activity Versus Role in Reverse Cholesterol Transport mdpi.com/3252632 #mdpiantioxidants via @antioxidants_OA
We quantified the clinical impact of variation on GH and IGF-1 measurements on the classification of acromegaly disease status in the UK
academic.oup.com/ejendo/arti…
@safwaan_adam
Bilal Bashir retweeted
Presented at #AHA24:
In a large trial involving patients with acute myocardial infarction, 95% of whom had ST-segment elevation myocardial infarction, spironolactone did not reduce the risk of cardiovascular events. Full CLEAR trial results: nej.md/4ftkpIc
ALT Time-to-event curves for the total number of events of death from cardiovascular causes or new or worsening heart failure.
Bilal Bashir retweeted
In the CLEAR randomized trial involving patients with acute myocardial infarction, colchicine did not decrease the risk of major adverse cardiovascular events over a median follow-up period of 3 years. Full trial results: nej.md/4i2U6dV
ALT Kaplan–Meier event curves for death from cardiovascular causes, recurrent myocardial infarction, stroke, or ischemia-driven revascularization.
Bilal Bashir retweeted
Nov. Featured Article: UK FCS registry: Higher pancreatitis risks but lower ASCVD rates in FCS vs. MCS; gene distribution varies by ethnicity
ahajrnls.org/3YJy0VT
#FCS is an ultra-rare disorder causing extremely high triglycerides,with significant delays in diagnosis and unmet clinical needs.Thanks to everyone who stopped by on FCS Awareness Day to learn about it
@ActionFCS @CheckOrphan @heartukcharity @MFTnhs @atherosociety @society_eas – at Cottam, England
Our latest article from UK FCS National Registry has been chosen as one of the two “Featured” articles in the November 2024 issue of @atvbahajournals
ahajournals.org/doi/10.1161/… – at Cottam, England
Bilal Bashir retweeted
HEART UK is delighted to announce the formation of the Early Career Cardiovascular Disease Prevention (ECCDP) Network designed to bring together junior & early-career HCPs & researchers to collaborate & share expertise.
heartuk.org.uk/professional-…
#lipids
Hypertriglyceridaemia in absence of diabetes causes peripheral & cardiac autonomic neuropathy.
@Neurodiab_eu
@heartukcharity
@OfficialUoM
@CVD_MFT
@MFT_Research – at Rome, Lazio
FCS leads to small fibre nerve damage, clinical neuropathy & early CAN
@Neurodiab_eu
@heartukcharity
@CVD_MFT
@RareDiseases
@CheckOrphan – at Rome, Lazio
Join researchers & clinicians at #ISA2024. Don’t miss opportunity to expand network while discussing how precision med can prevent,detect & manage cardiometabolic diseases. Use code ISAABILAL50 for discounted reg isa2024oman.org/
@atherosociety
@OslaOman
@heartukcharity
Cardivascular risk extends beyond LDL-C, but are their any other therapeutic targets? Does lowering triglycerides help?
frontiersin.org/journals/car… – at Cottam, England
