Emily O'Rourke (@eaorou) header
Emily O'Rourke (@eaorou) profile picture

Emily O'Rourke

@eaorou

Microbiology Ph.D. Candidate @CAMBUPenn in @SunnyShinLab 👩🏽‍🔬 | B.S. @MIT ‘21 | Latina 🇲🇽🇺🇸 | she/her | Eph. 2:4-5

 El Paso, TX
Joined June 2016
  • Tweets119
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  • Followers271
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Photo by Emily O'Rourke (@eaorou)Photo by Emily O'Rourke (@eaorou)Photo by Emily O'Rourke (@eaorou)Photo by Emily O'Rourke (@eaorou)Photo by Emily O'Rourke (@eaorou)Photo by Emily O'Rourke (@eaorou)Photo by Emily O'Rourke (@eaorou)
Thrilled to announce that I will be starting as an Assistant Professor in the Dept of Biology @swarthmore in the Fall! What an honor to be able to teach microbiology and mentor undergraduate students in the lab every day! This is my dream come true! I feel immensely grateful.
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Thrilled to share the latest collaborative study from @BrodskyIgor’s & my labs in @JExpMed describing a TNF-IL-1 circuit in monocytes that controls intestinal Yersinia infection! Congrats to amazing co-1st authors @RinaDoesScience, Daniel Sorobetea, & @JennaJZhang! 1/n
Journal of Experimental Medicine (@JExpMed) profile pictureJournal of Experimental Medicine@JExpMed16 Feb 2024
Collaborative study by @BrodskyIgor & @SunnyShinLab led by co-1st authors @RinaDoesScience, Daniel Sorobetea & @JennaJZhang uncovers a TNF-IL-1 signaling circuit in monocytes that controls intestinal Yersinia infection. hubs.la/Q02llbCJ0 #InnateImmunity #MucosalImmunology
Image from Journal of Experimental Medicine (@JExpMed)
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Emily O'Rourke retweeted
Igor Brodsky (@BrodskyIgor) profile picture
Igor Brodsky@BrodskyIgor17 Jan 2024
Our paper is out @eLife!! elifesciences.org/articles/8… Huge congrats to co-1st authors @DanielAkuma5 @RonitSchwartz99 @KAWodzanowski & thanks to co-senior authors @taabaman @SunnyShinLab & other collaborators for this amazing effort! For more info see thread: teapaw.org/BrodskyIgor/status/157…
Catalytic activity and autoprocessing of murine caspase-11 mediate noncanonical inflammasome...

Catalytic activity and autoprocessing of murine caspase-11 mediate noncanonical inflammasome...

Caspase-11 catalytic activity and autoprocessing play key roles upstream rather than downstream of its assembly into higher-order inflammasome complexes in response to cytosolic bacterial lipopolys...

elifesciences.org
Igor Brodsky (@BrodskyIgor) profile pictureIgor Brodsky@BrodskyIgor23 Sep 2022
Excited to share our story on noncanonical inflammasome assembly biorxiv.org/content/10.1101/…. This is the fruition of a lot of hard work by outstanding @CAMBUpenn MSTP student @DanielAkuma5, collab w new friend/colleague @taabaman & long-term collaborator/partner @SunnyShinLab🥰🧵
Noncanonical inflammasome assembly requires caspase-11 catalytic activity and intra-molecular...

Noncanonical inflammasome assembly requires caspase-11 catalytic activity and intra-molecular...

Inflammatory caspases are cysteine protease zymogens whose activation following infection or cellular damage occurs within supramolecular organizing centers (SMOCs) known as inflammsasomes. Inflamm...

biorxiv.org
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I had the amazing opportunity to talk about doing a Masters before a PhD. It was an honor to be on such a panel with so many accomplished PhD students and share our experiences! @ProjectShort open.spotify.com/episode/7cM…

SHORT Talk about Doing a Master's Before a PhD

SHORT Talks: The Official Project SHORT Podcast · Episode

open.spotify.com
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Our webinar "Demystifying Admissions into Biological/Biomedical PhD programs" will be on10/19 @ 2pm ET ⁠ Learn about the factors admissions committees consider in your Biological/Biomedical Sciences PhD! ⁠ Register here ➡️ cientificolatino.com/eventbr…
Image from Cientifico Latino, Inc. (@cientificolatin)
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So pleased that the first author on this paper cited as a key publication for today's Nobel Prize was supported by our NIGMS Cell & Molecular T32. 🍾😀 @kkariko @WeissmanLab @PennMedicine
Image from Dr. Marisa Bartolomei (@Marisa_S_B)
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Emily O'Rourke retweeted
Immunity (@ImmunityCP) profile picture
Immunity@ImmunityCP2 Oct 2023
One man's niche is another man's treasure 😀
John Schoggins (@jschoggins) profile pictureJohn Schoggins@jschoggins2 Oct 2023
‘Niche publication’?! Oh nytimes…
Image from John Schoggins (@jschoggins)
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Emily O'Rourke retweeted
The Nobel Prize (@NobelPrize) profile picture
The Nobel Prize
@NobelPrize2 Oct 2023
BREAKING NEWS The 2023 #NobelPrize in Physiology or Medicine has been awarded to Katalin Karikó and Drew Weissman for their discoveries concerning nucleoside base modifications that enabled the development of effective mRNA vaccines against COVID-19.
Image from The Nobel Prize (@NobelPrize)
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👩🏽‍🎓👨🏽‍🎓🧑🏾‍🎓👩🏾‍🎓🧑🏼‍🎓👩🏼‍🎓👨🏼‍🎓It's that time of year! Are you preparing to apply to grad school this fall? Sign up for the @IDEAL_Research Paths to PhD Programs in the Biomedical Sciences: tinyurl.com/576au95j Learn about @pennbgs & more. Our series starts on October 18th!
Image from Research Trainee Affairs at Penn Medicine (@RTAatPennMed)
Image from Research Trainee Affairs at Penn Medicine (@RTAatPennMed)
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So excited to share our story on human GBP1 facilitating rupture of the Legionella-containing vacuole & inflammasome activation @mbiojournal! So proud of 1st author & former @CAMBUpenn student Dr. @antoniabass, who is now at @Merck, & the co-authors! 🧵1/n journals.asm.org/doi/10.1128…
Human GBP1 facilitates the rupture of the Legionella-containing vacuole and inflammasome activation...

Human GBP1 facilitates the rupture of the Legionella-containing vacuole and inflammasome activation...

Inflammasomes are essential for host defense against intracellular bacterial pathogens like Legionella, as they activate caspases, which promote cytokine release and cell death to control infection....

journals.asm.org
Antonia Bass (@antoniabass) profile pictureAntonia Bass@antoniabass23 Jun 2020
Very excited to share my first first-author manuscript on my research conducted in the @SunnyShinLab as a preprint on bioRxiv!! #WomenInSTEM #BlackWomenInSTEM biorxiv.org/content/10.1101/…
Human GBP1 promotes pathogen vacuole rupture and inflammasome activation during Legionella pneumo...

Human GBP1 promotes pathogen vacuole rupture and inflammasome activation during Legionella pneumo...

The inflammasome is an essential component of host defense against intracellular bacterial pathogens, such as Legionella pneumophila , the causative agent of the severe pneumonia Legionnaires’...

biorxiv.org
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Emily O'Rourke retweeted
Igor Brodsky (@BrodskyIgor) profile picture
Igor Brodsky@BrodskyIgor16 Sep 2023
Excited to share the newest effort from @ronitschwartz99 @CAMBUpenn to understand the relationship between #pyroptosis and #apoptosis in #macrophages during Yersinia infection! 🧵1/ biorxiv.org/content/10.1101/…
Sequentially activated death complexes regulate pyroptosis and IL-1β release in response to...

Sequentially activated death complexes regulate pyroptosis and IL-1β release in response to...

The Yersinia virulence factor YopJ potently inhibits immune signaling in macrophages by blocking activation of the signaling kinases TAK1 and IKK. In response, macrophages trigger a backup pathway of...

biorxiv.org
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Awesome time at our 7th annual @CAMBUpenn MVP graduate program retreat! Fantastic talks & posters by faculty & students, along with science-themed Family Feud! Many thanks to MVP students @chattergenius & @TaylorSenay & MVP coordinator @anna_kline for their help organizing!
Image from Dr. Sunny Shin (@SunnyShinLab)
Image from Dr. Sunny Shin (@SunnyShinLab)
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Thrilled that our @eLife #ReviewedPreprint is now online! Congrats to 1st author @Marisa_Egan11 & co-authors @emily_a_orourke, @MageswaranKumar, Biao Zuo, Inna Martynuk, @Tabi_Demi18, Emma Hunter, @antoniabass, @yiweichang, & @BrodskyIgor! Thank you to the editors & reviewers!
Dr. Marisa Egan (@Marisa_Egan11) profile pictureDr. Marisa Egan@Marisa_Egan1119 Jul 2023
Very excited to share part of my thesis work in @SunnyShinLab's lab on bioRxiv: doi.org/10.1101/2023.07.17.5…! We found that inflammatory caspases and pyroptotic factors mediate inflammasome responses that restrict Salmonella replication primarily within the cytosol (1/13)
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Thrilled to share our lab’s latest @biorxivpreprint showing that inflammasomes primarily restrict Salmonella replication within the cytosol of human macrophages! Congratulations to 1st author & @cambupenn graduate Dr. @Marisa_Egan11 on this beautiful study! So proud of you! 🎉1/n
Dr. Marisa Egan (@Marisa_Egan11) profile pictureDr. Marisa Egan@Marisa_Egan1119 Jul 2023
Very excited to share part of my thesis work in @SunnyShinLab's lab on bioRxiv: doi.org/10.1101/2023.07.17.5…! We found that inflammatory caspases and pyroptotic factors mediate inflammasome responses that restrict Salmonella replication primarily within the cytosol (1/13)
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Congratulations to postdoc Xin Liu on starting as a tenure-track Assistant Professor in the Department of Biochemistry at @CWRUSOM next month! I am so proud & happy for you as you embark on this next chapter in your career! 🎉
Image from Dr. Sunny Shin (@SunnyShinLab)
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Fun night at the @Phillies with @SunnyShinLab and @BrodskyIgor labs for my first joint lab baseball game! Didn’t get to see a Schwarbomb this time, but hopefully next lab baseball outing!
Image from Dr. Kimberly Wodzanowski (@KAWodzanowski)
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Emily O'Rourke retweeted
Dr. Sunny Shin (@SunnyShinLab) profile picture
Dr. Sunny Shin@SunnyShinLab7 Jun 2023
Thrilled to share our lab’s latest in @PLOSPathogens on how TNF & caspases restrict Legionella infection! Congrats to 1st author & wonderful former @CAMBUpenn student @TzviPollock, & co-authors @IGGPenn student @vazquez_marrero & @BrodskyIgor! Tzvi’s excellent tweetorial below!
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Congratulations to our @CAMBUpenn MVP students on doing great on their preliminary exams & becoming PhD candidates! So awesome to be able to celebrate tonight with you! 🥳 Thanks to @BlackSheepPubPA for hosting us! 1/n – at Philadelphia, PA
Image from Dr. Sunny Shin (@SunnyShinLab)
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Congratulations to the newly minted Dr. @Marisa_Egan11 on a truly outstanding thesis defense! I am so proud of you & your many accomplishments in science, service, teaching, & mentoring! I look forward to seeing your continued success! @CAMBUpenn @PennMicro 🥳
Image from Dr. Sunny Shin (@SunnyShinLab)
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Dr. Sunny Shin (@SunnyShinLab) #WomenInSTEM is an Assoc. Prof. of @PennMicro. Dr. Shin has a notable reputation of mentoring and supporting students while guiding them towards reaching their scholarly potential🙌 Dr. Shin shares what she enjoys about mentoring #WomensHistoryMonth
Image from Research Trainee Affairs at Penn Medicine (@RTAatPennMed)
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